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Gene: SLC22A18 |
Gene summary for SLC22A18 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLC22A18 | Gene ID | 5002 |
Gene name | solute carrier family 22 member 18 | |
Gene Alias | BWR1A | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q96BI1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5002 | SLC22A18 | P23T-E | Human | Esophagus | ESCC | 7.70e-13 | 2.85e-01 | 0.108 |
5002 | SLC22A18 | P24T-E | Human | Esophagus | ESCC | 8.70e-15 | 3.50e-01 | 0.1287 |
5002 | SLC22A18 | P26T-E | Human | Esophagus | ESCC | 2.25e-22 | 2.87e-01 | 0.1276 |
5002 | SLC22A18 | P27T-E | Human | Esophagus | ESCC | 1.29e-14 | 2.80e-01 | 0.1055 |
5002 | SLC22A18 | P28T-E | Human | Esophagus | ESCC | 8.35e-22 | 4.54e-01 | 0.1149 |
5002 | SLC22A18 | P30T-E | Human | Esophagus | ESCC | 1.05e-15 | 4.99e-01 | 0.137 |
5002 | SLC22A18 | P31T-E | Human | Esophagus | ESCC | 1.09e-19 | 2.92e-01 | 0.1251 |
5002 | SLC22A18 | P32T-E | Human | Esophagus | ESCC | 1.73e-33 | 6.41e-01 | 0.1666 |
5002 | SLC22A18 | P36T-E | Human | Esophagus | ESCC | 7.59e-13 | 3.84e-01 | 0.1187 |
5002 | SLC22A18 | P37T-E | Human | Esophagus | ESCC | 6.85e-20 | 4.31e-01 | 0.1371 |
5002 | SLC22A18 | P38T-E | Human | Esophagus | ESCC | 9.49e-04 | 1.81e-01 | 0.127 |
5002 | SLC22A18 | P39T-E | Human | Esophagus | ESCC | 3.93e-06 | 6.13e-02 | 0.0894 |
5002 | SLC22A18 | P40T-E | Human | Esophagus | ESCC | 4.76e-10 | 2.87e-01 | 0.109 |
5002 | SLC22A18 | P42T-E | Human | Esophagus | ESCC | 1.06e-16 | 4.45e-01 | 0.1175 |
5002 | SLC22A18 | P44T-E | Human | Esophagus | ESCC | 1.19e-07 | 2.26e-01 | 0.1096 |
5002 | SLC22A18 | P47T-E | Human | Esophagus | ESCC | 5.90e-22 | 4.34e-01 | 0.1067 |
5002 | SLC22A18 | P48T-E | Human | Esophagus | ESCC | 1.21e-16 | 3.31e-01 | 0.0959 |
5002 | SLC22A18 | P49T-E | Human | Esophagus | ESCC | 4.79e-13 | 1.14e+00 | 0.1768 |
5002 | SLC22A18 | P52T-E | Human | Esophagus | ESCC | 1.11e-28 | 5.46e-01 | 0.1555 |
5002 | SLC22A18 | P54T-E | Human | Esophagus | ESCC | 7.93e-10 | 2.35e-01 | 0.0975 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902600 | Colorectum | AD | proton transmembrane transport | 66/3918 | 157/18723 | 1.59e-09 | 1.17e-07 | 66 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:19026001 | Colorectum | SER | proton transmembrane transport | 60/2897 | 157/18723 | 3.12e-12 | 7.08e-10 | 60 |
GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
GO:00987541 | Colorectum | SER | detoxification | 46/2897 | 152/18723 | 3.02e-06 | 1.20e-04 | 46 |
GO:19026002 | Colorectum | MSS | proton transmembrane transport | 57/3467 | 157/18723 | 1.00e-07 | 4.81e-06 | 57 |
GO:00096362 | Colorectum | MSS | response to toxic substance | 73/3467 | 262/18723 | 1.26e-04 | 1.94e-03 | 73 |
GO:00987542 | Colorectum | MSS | detoxification | 41/3467 | 152/18723 | 6.41e-03 | 4.27e-02 | 41 |
GO:19026004 | Colorectum | FAP | proton transmembrane transport | 39/2622 | 157/18723 | 2.03e-04 | 2.92e-03 | 39 |
GO:00096363 | Colorectum | FAP | response to toxic substance | 53/2622 | 262/18723 | 3.35e-03 | 2.46e-02 | 53 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:190260018 | Esophagus | ESCC | proton transmembrane transport | 88/8552 | 157/18723 | 5.62e-03 | 2.10e-02 | 88 |
GO:000963612 | Liver | Cirrhotic | response to toxic substance | 104/4634 | 262/18723 | 5.63e-08 | 1.74e-06 | 104 |
GO:00987547 | Liver | Cirrhotic | detoxification | 60/4634 | 152/18723 | 4.09e-05 | 4.86e-04 | 60 |
GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
GO:009875412 | Liver | HCC | detoxification | 87/7958 | 152/18723 | 1.70e-04 | 1.35e-03 | 87 |
GO:19026007 | Liver | HCC | proton transmembrane transport | 87/7958 | 157/18723 | 7.27e-04 | 4.42e-03 | 87 |
GO:000963618 | Oral cavity | OSCC | response to toxic substance | 137/7305 | 262/18723 | 7.94e-06 | 8.52e-05 | 137 |
GO:009875418 | Oral cavity | OSCC | detoxification | 75/7305 | 152/18723 | 5.99e-03 | 2.28e-02 | 75 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A18 | SNV | Missense_Mutation | novel | c.25N>T | p.Asp9Tyr | p.D9Y | Q96BI1 | protein_coding | deleterious(0.03) | benign(0.094) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC22A18 | SNV | Missense_Mutation | novel | c.653N>T | p.Pro218Leu | p.P218L | Q96BI1 | protein_coding | deleterious(0.04) | benign(0.089) | TCGA-OL-A5D7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
SLC22A18 | SNV | Missense_Mutation | rs780830210 | c.994N>C | p.Cys332Arg | p.C332R | Q96BI1 | protein_coding | deleterious(0) | possibly_damaging(0.774) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC22A18 | SNV | Missense_Mutation | novel | c.937N>G | p.Leu313Val | p.L313V | Q96BI1 | protein_coding | tolerated(0.25) | benign(0.07) | TCGA-AA-3531-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC22A18 | SNV | Missense_Mutation | c.763N>T | p.Gly255Trp | p.G255W | Q96BI1 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC22A18 | SNV | Missense_Mutation | c.451N>A | p.Ala151Thr | p.A151T | Q96BI1 | protein_coding | tolerated(0.5) | benign(0.096) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC22A18 | deletion | Frame_Shift_Del | c.1136_1137delNN | p.Leu379ArgfsTer? | p.L379Rfs*? | Q96BI1 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SLC22A18 | SNV | Missense_Mutation | novel | c.799N>A | p.Asp267Asn | p.D267N | Q96BI1 | protein_coding | tolerated(0.11) | benign(0.078) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC22A18 | SNV | Missense_Mutation | novel | c.220N>A | p.Leu74Met | p.L74M | Q96BI1 | protein_coding | deleterious(0.01) | possibly_damaging(0.625) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC22A18 | SNV | Missense_Mutation | rs770154192 | c.694N>A | p.Ala232Thr | p.A232T | Q96BI1 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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