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Gene: SELENOW |
Gene summary for SELENOW |
Gene summary. |
Gene information | Species | Human | Gene symbol | SELENOW | Gene ID | 6415 |
Gene name | selenoprotein W | |
Gene Alias | SEPW1 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P63302 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6415 | SELENOW | CA_HPV_3 | Human | Cervix | CC | 2.82e-04 | 1.74e-01 | 0.0414 |
6415 | SELENOW | CCI_1 | Human | Cervix | CC | 1.57e-11 | -8.33e-01 | 0.528 |
6415 | SELENOW | CCI_2 | Human | Cervix | CC | 1.04e-03 | -5.82e-01 | 0.5249 |
6415 | SELENOW | CCI_3 | Human | Cervix | CC | 8.84e-17 | -8.60e-01 | 0.516 |
6415 | SELENOW | CCII_1 | Human | Cervix | CC | 1.04e-20 | -8.31e-01 | 0.3249 |
6415 | SELENOW | Tumor | Human | Cervix | CC | 1.32e-57 | -9.52e-01 | 0.1241 |
6415 | SELENOW | sample3 | Human | Cervix | CC | 9.05e-41 | 5.79e-01 | 0.1387 |
6415 | SELENOW | L1 | Human | Cervix | CC | 2.57e-06 | -1.80e-01 | 0.0802 |
6415 | SELENOW | T3 | Human | Cervix | CC | 2.91e-29 | 5.50e-01 | 0.1389 |
6415 | SELENOW | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.33e-14 | 6.17e-01 | 0.0155 |
6415 | SELENOW | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.14e-31 | 1.63e+00 | -0.1808 |
6415 | SELENOW | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.52e-03 | 6.57e-01 | 0.0216 |
6415 | SELENOW | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.70e-34 | 1.76e+00 | -0.0811 |
6415 | SELENOW | HTA11_78_2000001011 | Human | Colorectum | AD | 1.06e-11 | 7.85e-01 | -0.1088 |
6415 | SELENOW | HTA11_347_2000001011 | Human | Colorectum | AD | 2.40e-37 | 1.17e+00 | -0.1954 |
6415 | SELENOW | HTA11_411_2000001011 | Human | Colorectum | SER | 1.75e-16 | 2.03e+00 | -0.2602 |
6415 | SELENOW | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.66e-06 | 1.34e+00 | -0.2196 |
6415 | SELENOW | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.27e-21 | 1.17e+00 | -0.1207 |
6415 | SELENOW | HTA11_83_2000001011 | Human | Colorectum | SER | 2.93e-21 | 1.25e+00 | -0.1526 |
6415 | SELENOW | HTA11_696_2000001011 | Human | Colorectum | AD | 1.18e-25 | 8.66e-01 | -0.1464 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00988698 | Breast | Precancer | cellular oxidant detoxification | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:19907488 | Breast | Precancer | cellular detoxification | 21/1080 | 116/18723 | 2.67e-06 | 8.89e-05 | 21 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00972378 | Breast | Precancer | cellular response to toxic substance | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:00102693 | Breast | Precancer | response to selenium ion | 4/1080 | 11/18723 | 2.62e-03 | 2.34e-02 | 4 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:009875413 | Breast | IDC | detoxification | 29/1434 | 152/18723 | 3.97e-06 | 1.43e-04 | 29 |
GO:009886913 | Breast | IDC | cellular oxidant detoxification | 22/1434 | 101/18723 | 6.31e-06 | 1.98e-04 | 22 |
GO:199074813 | Breast | IDC | cellular detoxification | 23/1434 | 116/18723 | 2.02e-05 | 4.92e-04 | 23 |
GO:009723713 | Breast | IDC | cellular response to toxic substance | 24/1434 | 124/18723 | 2.05e-05 | 4.97e-04 | 24 |
GO:00102691 | Breast | IDC | response to selenium ion | 6/1434 | 11/18723 | 6.59e-05 | 1.35e-03 | 6 |
GO:000963623 | Breast | DCIS | response to toxic substance | 42/1390 | 262/18723 | 1.76e-06 | 6.56e-05 | 42 |
GO:009875423 | Breast | DCIS | detoxification | 29/1390 | 152/18723 | 2.15e-06 | 7.79e-05 | 29 |
GO:009886923 | Breast | DCIS | cellular oxidant detoxification | 22/1390 | 101/18723 | 3.82e-06 | 1.16e-04 | 22 |
GO:199074823 | Breast | DCIS | cellular detoxification | 23/1390 | 116/18723 | 1.22e-05 | 3.12e-04 | 23 |
GO:009723723 | Breast | DCIS | cellular response to toxic substance | 24/1390 | 124/18723 | 1.22e-05 | 3.12e-04 | 24 |
GO:00102692 | Breast | DCIS | response to selenium ion | 6/1390 | 11/18723 | 5.53e-05 | 1.12e-03 | 6 |
GO:00988699 | Cervix | CC | cellular oxidant detoxification | 30/2311 | 101/18723 | 2.72e-06 | 7.93e-05 | 30 |
GO:19907489 | Cervix | CC | cellular detoxification | 30/2311 | 116/18723 | 5.34e-05 | 7.94e-04 | 30 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENOW | SNV | Missense_Mutation | novel | c.210A>C | p.Glu70Asp | p.E70D | P63302 | protein_coding | tolerated(0.48) | possibly_damaging(0.787) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | c.235G>A | p.Ala79Thr | p.A79T | P63302 | protein_coding | tolerated(0.16) | possibly_damaging(0.893) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
SELENOW | SNV | Missense_Mutation | novel | c.212N>T | p.Ser71Ile | p.S71I | P63302 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | novel | c.72G>T | p.Lys24Asn | p.K24N | P63302 | protein_coding | tolerated(0.11) | possibly_damaging(0.463) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SELENOW | SNV | Missense_Mutation | novel | c.251N>C | p.Leu84Ser | p.L84S | P63302 | protein_coding | deleterious(0) | benign(0.146) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SELENOW | SNV | Missense_Mutation | novel | c.157N>T | p.Ala53Ser | p.A53S | P63302 | protein_coding | tolerated(0.56) | benign(0.303) | TCGA-VQ-A8DT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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