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Gene: RWDD4 |
Gene summary for RWDD4 |
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Gene information | Species | Human | Gene symbol | RWDD4 | Gene ID | 201965 |
Gene name | RWD domain containing 4 | |
Gene Alias | FAM28A | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | E7EV43 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
201965 | RWDD4 | P49T-E | Human | Esophagus | ESCC | 1.64e-12 | 1.34e+00 | 0.1768 |
201965 | RWDD4 | P52T-E | Human | Esophagus | ESCC | 1.13e-35 | 7.31e-01 | 0.1555 |
201965 | RWDD4 | P54T-E | Human | Esophagus | ESCC | 2.25e-49 | 1.10e+00 | 0.0975 |
201965 | RWDD4 | P56T-E | Human | Esophagus | ESCC | 1.84e-08 | 1.03e+00 | 0.1613 |
201965 | RWDD4 | P57T-E | Human | Esophagus | ESCC | 1.74e-17 | 3.47e-01 | 0.0926 |
201965 | RWDD4 | P61T-E | Human | Esophagus | ESCC | 8.47e-05 | 1.73e-01 | 0.099 |
201965 | RWDD4 | P62T-E | Human | Esophagus | ESCC | 1.24e-53 | 9.21e-01 | 0.1302 |
201965 | RWDD4 | P65T-E | Human | Esophagus | ESCC | 3.31e-23 | 5.52e-01 | 0.0978 |
201965 | RWDD4 | P74T-E | Human | Esophagus | ESCC | 1.88e-36 | 1.14e+00 | 0.1479 |
201965 | RWDD4 | P75T-E | Human | Esophagus | ESCC | 5.72e-17 | 3.33e-01 | 0.1125 |
201965 | RWDD4 | P76T-E | Human | Esophagus | ESCC | 5.13e-41 | 7.45e-01 | 0.1207 |
201965 | RWDD4 | P79T-E | Human | Esophagus | ESCC | 1.98e-30 | 5.22e-01 | 0.1154 |
201965 | RWDD4 | P80T-E | Human | Esophagus | ESCC | 8.03e-67 | 2.05e+00 | 0.155 |
201965 | RWDD4 | P82T-E | Human | Esophagus | ESCC | 2.20e-13 | 6.83e-01 | 0.1072 |
201965 | RWDD4 | P83T-E | Human | Esophagus | ESCC | 1.51e-35 | 1.14e+00 | 0.1738 |
201965 | RWDD4 | P84T-E | Human | Esophagus | ESCC | 1.04e-05 | 4.17e-01 | 0.0933 |
201965 | RWDD4 | P89T-E | Human | Esophagus | ESCC | 2.18e-14 | 1.08e+00 | 0.1752 |
201965 | RWDD4 | P91T-E | Human | Esophagus | ESCC | 5.41e-15 | 1.58e+00 | 0.1828 |
201965 | RWDD4 | P107T-E | Human | Esophagus | ESCC | 6.68e-41 | 1.04e+00 | 0.171 |
201965 | RWDD4 | P126T-E | Human | Esophagus | ESCC | 8.84e-08 | 8.05e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RWDD4 | SNV | Missense_Mutation | c.92C>A | p.Ser31Tyr | p.S31Y | Q6NW29 | protein_coding | deleterious(0.01) | possibly_damaging(0.837) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RWDD4 | insertion | Frame_Shift_Ins | novel | c.204_205insT | p.Asn69Ter | p.N69* | Q6NW29 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
RWDD4 | SNV | Missense_Mutation | novel | c.376A>G | p.Asn126Asp | p.N126D | Q6NW29 | protein_coding | tolerated(0.47) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RWDD4 | SNV | Missense_Mutation | novel | c.296C>T | p.Thr99Ile | p.T99I | Q6NW29 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RWDD4 | SNV | Missense_Mutation | novel | c.427N>T | p.Asp143Tyr | p.D143Y | Q6NW29 | protein_coding | deleterious(0.01) | benign(0.44) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RWDD4 | SNV | Missense_Mutation | novel | c.517G>A | p.Val173Ile | p.V173I | Q6NW29 | protein_coding | tolerated(0.06) | benign(0.236) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RWDD4 | SNV | Missense_Mutation | rs752249282 | c.461N>A | p.Arg154His | p.R154H | Q6NW29 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
RWDD4 | SNV | Missense_Mutation | novel | c.163N>C | p.Tyr55His | p.Y55H | Q6NW29 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RWDD4 | SNV | Missense_Mutation | novel | c.428N>G | p.Asp143Gly | p.D143G | Q6NW29 | protein_coding | tolerated(0.06) | benign(0.075) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RWDD4 | insertion | Frame_Shift_Ins | novel | c.204dupT | p.Asn69Ter | p.N69* | Q6NW29 | protein_coding | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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