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Gene: RPA3 |
Gene summary for RPA3 |
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Gene information | Species | Human | Gene symbol | RPA3 | Gene ID | 6119 |
Gene name | replication protein A3 | |
Gene Alias | REPA3 | |
Cytomap | 7p21.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A4D105 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6119 | RPA3 | P9T-E | Human | Esophagus | ESCC | 6.62e-24 | 7.48e-01 | 0.1131 |
6119 | RPA3 | P10T-E | Human | Esophagus | ESCC | 3.39e-24 | 6.53e-01 | 0.116 |
6119 | RPA3 | P11T-E | Human | Esophagus | ESCC | 1.31e-16 | 7.93e-01 | 0.1426 |
6119 | RPA3 | P12T-E | Human | Esophagus | ESCC | 1.13e-25 | 8.05e-01 | 0.1122 |
6119 | RPA3 | P15T-E | Human | Esophagus | ESCC | 2.32e-30 | 8.49e-01 | 0.1149 |
6119 | RPA3 | P16T-E | Human | Esophagus | ESCC | 8.07e-37 | 8.78e-01 | 0.1153 |
6119 | RPA3 | P17T-E | Human | Esophagus | ESCC | 1.00e-15 | 1.20e+00 | 0.1278 |
6119 | RPA3 | P19T-E | Human | Esophagus | ESCC | 5.17e-06 | 1.53e+00 | 0.1662 |
6119 | RPA3 | P20T-E | Human | Esophagus | ESCC | 1.30e-25 | 6.91e-01 | 0.1124 |
6119 | RPA3 | P21T-E | Human | Esophagus | ESCC | 1.55e-50 | 1.38e+00 | 0.1617 |
6119 | RPA3 | P22T-E | Human | Esophagus | ESCC | 2.86e-31 | 9.06e-01 | 0.1236 |
6119 | RPA3 | P23T-E | Human | Esophagus | ESCC | 7.58e-28 | 9.55e-01 | 0.108 |
6119 | RPA3 | P24T-E | Human | Esophagus | ESCC | 3.47e-23 | 9.07e-01 | 0.1287 |
6119 | RPA3 | P26T-E | Human | Esophagus | ESCC | 4.24e-24 | 8.33e-01 | 0.1276 |
6119 | RPA3 | P27T-E | Human | Esophagus | ESCC | 2.49e-27 | 7.65e-01 | 0.1055 |
6119 | RPA3 | P28T-E | Human | Esophagus | ESCC | 5.56e-23 | 8.12e-01 | 0.1149 |
6119 | RPA3 | P30T-E | Human | Esophagus | ESCC | 1.17e-16 | 1.03e+00 | 0.137 |
6119 | RPA3 | P31T-E | Human | Esophagus | ESCC | 7.36e-39 | 1.16e+00 | 0.1251 |
6119 | RPA3 | P32T-E | Human | Esophagus | ESCC | 1.00e-47 | 1.57e+00 | 0.1666 |
6119 | RPA3 | P36T-E | Human | Esophagus | ESCC | 1.17e-09 | 5.55e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:00322003 | Breast | Precancer | telomere organization | 20/1080 | 159/18723 | 8.45e-04 | 9.82e-03 | 20 |
GO:000072312 | Breast | IDC | telomere maintenance | 21/1434 | 131/18723 | 9.62e-04 | 1.09e-02 | 21 |
GO:00073465 | Breast | IDC | regulation of mitotic cell cycle | 51/1434 | 457/18723 | 4.30e-03 | 3.35e-02 | 51 |
GO:000072321 | Breast | DCIS | telomere maintenance | 21/1390 | 131/18723 | 6.45e-04 | 7.96e-03 | 21 |
GO:000734612 | Breast | DCIS | regulation of mitotic cell cycle | 52/1390 | 457/18723 | 1.38e-03 | 1.43e-02 | 52 |
GO:003220011 | Breast | DCIS | telomere organization | 21/1390 | 159/18723 | 7.13e-03 | 4.85e-02 | 21 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00007239 | Cervix | CC | telomere maintenance | 26/2311 | 131/18723 | 9.33e-03 | 4.66e-02 | 26 |
GO:000072318 | Esophagus | HGIN | telomere maintenance | 38/2587 | 131/18723 | 4.38e-06 | 1.42e-04 | 38 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:00322007 | Esophagus | HGIN | telomere organization | 38/2587 | 159/18723 | 4.23e-04 | 6.39e-03 | 38 |
GO:00062892 | Esophagus | HGIN | nucleotide-excision repair | 16/2587 | 60/18723 | 6.22e-03 | 4.95e-02 | 16 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
GO:00062843 | Esophagus | ESCC | base-excision repair | 33/8552 | 43/18723 | 3.25e-05 | 2.69e-04 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa034205 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa0342012 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa030304 | Esophagus | ESCC | DNA replication | 32/4205 | 36/8465 | 7.71e-07 | 5.06e-06 | 2.59e-06 | 32 |
hsa034304 | Esophagus | ESCC | Mismatch repair | 21/4205 | 23/8465 | 2.85e-05 | 1.35e-04 | 6.90e-05 | 21 |
hsa0342032 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0303011 | Esophagus | ESCC | DNA replication | 32/4205 | 36/8465 | 7.71e-07 | 5.06e-06 | 2.59e-06 | 32 |
hsa0343011 | Esophagus | ESCC | Mismatch repair | 21/4205 | 23/8465 | 2.85e-05 | 1.35e-04 | 6.90e-05 | 21 |
hsa03420 | Liver | Cirrhotic | Nucleotide excision repair | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa034201 | Liver | Cirrhotic | Nucleotide excision repair | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa034202 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034203 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa034204 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa03030 | Oral cavity | OSCC | DNA replication | 31/3704 | 36/8465 | 1.70e-07 | 1.19e-06 | 6.03e-07 | 31 |
hsa03430 | Oral cavity | OSCC | Mismatch repair | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0342011 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa030301 | Oral cavity | OSCC | DNA replication | 31/3704 | 36/8465 | 1.70e-07 | 1.19e-06 | 6.03e-07 | 31 |
hsa034301 | Oral cavity | OSCC | Mismatch repair | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0342021 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030302 | Oral cavity | LP | DNA replication | 23/2418 | 36/8465 | 1.08e-05 | 7.79e-05 | 5.02e-05 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPA3 | SNV | Missense_Mutation | c.345A>T | p.Leu115Phe | p.L115F | P35244 | protein_coding | tolerated(1) | benign(0) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
RPA3 | SNV | Missense_Mutation | c.7G>A | p.Asp3Asn | p.D3N | P35244 | protein_coding | deleterious(0.04) | possibly_damaging(0.554) | TCGA-D8-A27W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
RPA3 | SNV | Missense_Mutation | c.160G>A | p.Glu54Lys | p.E54K | P35244 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
RPA3 | SNV | Missense_Mutation | novel | c.278N>A | p.Pro93His | p.P93H | P35244 | protein_coding | deleterious(0.03) | benign(0.388) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RPA3 | SNV | Missense_Mutation | c.361G>T | p.Asp121Tyr | p.D121Y | P35244 | protein_coding | deleterious_low_confidence(0) | benign(0.365) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
RPA3 | SNV | Missense_Mutation | c.44N>C | p.Gly15Ala | p.G15A | P35244 | protein_coding | tolerated(0.19) | benign(0) | TCGA-44-7660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Vaccine | recprame+as15 | PD | |
RPA3 | SNV | Missense_Mutation | novel | c.68N>T | p.Lys23Met | p.K23M | P35244 | protein_coding | deleterious(0) | benign(0.274) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
RPA3 | SNV | Missense_Mutation | rs774710098 | c.352N>A | p.Val118Met | p.V118M | P35244 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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