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Gene: RIMKLB |
Gene summary for RIMKLB |
Gene summary. |
Gene information | Species | Human | Gene symbol | RIMKLB | Gene ID | 57494 |
Gene name | ribosomal modification protein rimK like family member B | |
Gene Alias | FAM80B | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9ULI2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57494 | RIMKLB | P62T-E | Human | Esophagus | ESCC | 8.32e-23 | 3.79e-01 | 0.1302 |
57494 | RIMKLB | P65T-E | Human | Esophagus | ESCC | 1.40e-17 | 2.13e-01 | 0.0978 |
57494 | RIMKLB | P74T-E | Human | Esophagus | ESCC | 2.54e-07 | 3.57e-01 | 0.1479 |
57494 | RIMKLB | P75T-E | Human | Esophagus | ESCC | 1.57e-10 | 7.96e-02 | 0.1125 |
57494 | RIMKLB | P76T-E | Human | Esophagus | ESCC | 8.66e-07 | 2.06e-01 | 0.1207 |
57494 | RIMKLB | P79T-E | Human | Esophagus | ESCC | 1.53e-22 | 4.09e-01 | 0.1154 |
57494 | RIMKLB | P80T-E | Human | Esophagus | ESCC | 7.27e-32 | 8.19e-01 | 0.155 |
57494 | RIMKLB | P82T-E | Human | Esophagus | ESCC | 4.93e-08 | 2.57e-01 | 0.1072 |
57494 | RIMKLB | P83T-E | Human | Esophagus | ESCC | 1.25e-17 | 4.43e-01 | 0.1738 |
57494 | RIMKLB | P84T-E | Human | Esophagus | ESCC | 3.44e-02 | 2.76e-01 | 0.0933 |
57494 | RIMKLB | P107T-E | Human | Esophagus | ESCC | 1.78e-14 | 2.60e-01 | 0.171 |
57494 | RIMKLB | P127T-E | Human | Esophagus | ESCC | 5.71e-10 | 6.47e-02 | 0.0826 |
57494 | RIMKLB | P128T-E | Human | Esophagus | ESCC | 3.52e-08 | 2.02e-01 | 0.1241 |
57494 | RIMKLB | P130T-E | Human | Esophagus | ESCC | 1.90e-54 | 1.50e+00 | 0.1676 |
57494 | RIMKLB | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.58e-03 | 2.25e-01 | -0.0132 |
57494 | RIMKLB | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.48e-07 | 2.24e-01 | -0.013 |
57494 | RIMKLB | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 4.43e-03 | 2.56e-01 | -0.0121 |
57494 | RIMKLB | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 9.25e-05 | 7.00e-01 | -0.0876 |
57494 | RIMKLB | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 7.51e-04 | 7.12e-01 | -0.0809 |
57494 | RIMKLB | C04 | Human | Oral cavity | OSCC | 1.19e-09 | 7.89e-01 | 0.2633 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIMKLB | SNV | Missense_Mutation | c.479C>T | p.Thr160Met | p.T160M | Q9ULI2 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-BH-A0BL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
RIMKLB | SNV | Missense_Mutation | novel | c.902N>G | p.Asp301Gly | p.D301G | Q9ULI2 | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-EW-A6SA-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RIMKLB | insertion | Frame_Shift_Ins | novel | c.1159_1160insTCCTTATACTTGGTTTATATTATTGCAA | p.Ter387PhefsTer31 | p.*387Ffs*31 | Q9ULI2 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
RIMKLB | SNV | Missense_Mutation | c.515N>C | p.Arg172Pro | p.R172P | Q9ULI2 | protein_coding | tolerated(0.32) | probably_damaging(0.915) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
RIMKLB | SNV | Missense_Mutation | novel | c.319C>G | p.Gln107Glu | p.Q107E | Q9ULI2 | protein_coding | tolerated(0.27) | benign(0.018) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
RIMKLB | SNV | Missense_Mutation | novel | c.184N>G | p.Ile62Val | p.I62V | Q9ULI2 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RIMKLB | SNV | Missense_Mutation | novel | c.94G>A | p.Ala32Thr | p.A32T | Q9ULI2 | protein_coding | tolerated(0.37) | benign(0.045) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RIMKLB | SNV | Missense_Mutation | novel | c.128N>T | p.Ala43Val | p.A43V | Q9ULI2 | protein_coding | tolerated(0.5) | benign(0.014) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIMKLB | SNV | Missense_Mutation | novel | c.460N>T | p.Pro154Ser | p.P154S | Q9ULI2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIMKLB | SNV | Missense_Mutation | c.291N>T | p.Lys97Asn | p.K97N | Q9ULI2 | protein_coding | tolerated(0.07) | benign(0.013) | TCGA-AA-3986-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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