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Gene: RIC8A |
Gene summary for RIC8A |
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Gene information | Species | Human | Gene symbol | RIC8A | Gene ID | 60626 |
Gene name | RIC8 guanine nucleotide exchange factor A | |
Gene Alias | RIC8 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | Q9NPQ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60626 | RIC8A | P52T-E | Human | Esophagus | ESCC | 2.74e-33 | 8.55e-01 | 0.1555 |
60626 | RIC8A | P54T-E | Human | Esophagus | ESCC | 5.82e-14 | 2.85e-01 | 0.0975 |
60626 | RIC8A | P56T-E | Human | Esophagus | ESCC | 5.68e-07 | 1.10e+00 | 0.1613 |
60626 | RIC8A | P57T-E | Human | Esophagus | ESCC | 3.35e-20 | 4.01e-01 | 0.0926 |
60626 | RIC8A | P61T-E | Human | Esophagus | ESCC | 2.87e-15 | 3.89e-01 | 0.099 |
60626 | RIC8A | P62T-E | Human | Esophagus | ESCC | 9.55e-58 | 9.81e-01 | 0.1302 |
60626 | RIC8A | P65T-E | Human | Esophagus | ESCC | 4.82e-20 | 2.97e-01 | 0.0978 |
60626 | RIC8A | P74T-E | Human | Esophagus | ESCC | 6.73e-45 | 1.06e+00 | 0.1479 |
60626 | RIC8A | P75T-E | Human | Esophagus | ESCC | 1.31e-46 | 9.12e-01 | 0.1125 |
60626 | RIC8A | P76T-E | Human | Esophagus | ESCC | 1.18e-24 | 4.79e-01 | 0.1207 |
60626 | RIC8A | P79T-E | Human | Esophagus | ESCC | 1.39e-30 | 5.39e-01 | 0.1154 |
60626 | RIC8A | P80T-E | Human | Esophagus | ESCC | 1.18e-39 | 1.13e+00 | 0.155 |
60626 | RIC8A | P82T-E | Human | Esophagus | ESCC | 5.51e-15 | 9.70e-01 | 0.1072 |
60626 | RIC8A | P83T-E | Human | Esophagus | ESCC | 3.23e-40 | 1.06e+00 | 0.1738 |
60626 | RIC8A | P84T-E | Human | Esophagus | ESCC | 9.01e-07 | 1.63e-01 | 0.0933 |
60626 | RIC8A | P89T-E | Human | Esophagus | ESCC | 3.23e-19 | 1.11e+00 | 0.1752 |
60626 | RIC8A | P91T-E | Human | Esophagus | ESCC | 1.52e-19 | 1.90e+00 | 0.1828 |
60626 | RIC8A | P107T-E | Human | Esophagus | ESCC | 1.58e-36 | 7.80e-01 | 0.171 |
60626 | RIC8A | P126T-E | Human | Esophagus | ESCC | 1.04e-09 | 7.34e-01 | 0.1125 |
60626 | RIC8A | P127T-E | Human | Esophagus | ESCC | 1.43e-12 | 6.79e-02 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:00073698 | Esophagus | ESCC | gastrulation | 115/8552 | 185/18723 | 4.35e-06 | 4.64e-05 | 115 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:00717115 | Esophagus | ESCC | basement membrane organization | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:0071711 | Liver | Cirrhotic | basement membrane organization | 17/4634 | 31/18723 | 3.19e-04 | 2.77e-03 | 17 |
GO:000166712 | Liver | Cirrhotic | ameboidal-type cell migration | 145/4634 | 475/18723 | 2.23e-03 | 1.36e-02 | 145 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:000166719 | Oral cavity | OSCC | ameboidal-type cell migration | 228/7305 | 475/18723 | 3.46e-05 | 3.10e-04 | 228 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
GO:00073697 | Oral cavity | OSCC | gastrulation | 95/7305 | 185/18723 | 4.17e-04 | 2.54e-03 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIC8A | SNV | Missense_Mutation | novel | c.1443G>T | p.Gln481His | p.Q481H | Q9NPQ8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RIC8A | SNV | Missense_Mutation | novel | c.1000N>C | p.Val334Leu | p.V334L | Q9NPQ8 | protein_coding | deleterious(0.01) | possibly_damaging(0.595) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
RIC8A | SNV | Missense_Mutation | c.1261N>G | p.Asn421Asp | p.N421D | Q9NPQ8 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
RIC8A | SNV | Missense_Mutation | rs367798950 | c.1154N>A | p.Arg385His | p.R385H | Q9NPQ8 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RIC8A | SNV | Missense_Mutation | novel | c.455N>T | p.Arg152Leu | p.R152L | Q9NPQ8 | protein_coding | tolerated(0.7) | benign(0.175) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RIC8A | SNV | Missense_Mutation | novel | c.1327N>A | p.Glu443Lys | p.E443K | Q9NPQ8 | protein_coding | deleterious(0.02) | benign(0.276) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RIC8A | SNV | Missense_Mutation | novel | c.1195G>A | p.Ala399Thr | p.A399T | Q9NPQ8 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
RIC8A | SNV | Missense_Mutation | c.1339N>G | p.Thr447Ala | p.T447A | Q9NPQ8 | protein_coding | deleterious(0) | possibly_damaging(0.523) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RIC8A | SNV | Missense_Mutation | rs368432680 | c.767G>A | p.Arg256Gln | p.R256Q | Q9NPQ8 | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RIC8A | SNV | Missense_Mutation | rs751745965 | c.931C>T | p.Arg311Cys | p.R311C | Q9NPQ8 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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