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Gene: RFK |
Gene summary for RFK |
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Gene information | Species | Human | Gene symbol | RFK | Gene ID | 55312 |
Gene name | riboflavin kinase | |
Gene Alias | RIFK | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B2RDZ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55312 | RFK | P44T-E | Human | Esophagus | ESCC | 3.77e-05 | 2.86e-01 | 0.1096 |
55312 | RFK | P47T-E | Human | Esophagus | ESCC | 7.04e-12 | 2.34e-01 | 0.1067 |
55312 | RFK | P48T-E | Human | Esophagus | ESCC | 1.21e-08 | 1.33e-01 | 0.0959 |
55312 | RFK | P49T-E | Human | Esophagus | ESCC | 3.56e-07 | 4.50e-01 | 0.1768 |
55312 | RFK | P52T-E | Human | Esophagus | ESCC | 3.01e-15 | 4.04e-01 | 0.1555 |
55312 | RFK | P54T-E | Human | Esophagus | ESCC | 3.13e-12 | 3.39e-01 | 0.0975 |
55312 | RFK | P56T-E | Human | Esophagus | ESCC | 2.76e-02 | 3.59e-01 | 0.1613 |
55312 | RFK | P57T-E | Human | Esophagus | ESCC | 1.15e-13 | 4.18e-01 | 0.0926 |
55312 | RFK | P61T-E | Human | Esophagus | ESCC | 2.40e-08 | 2.06e-01 | 0.099 |
55312 | RFK | P62T-E | Human | Esophagus | ESCC | 2.34e-18 | 4.32e-01 | 0.1302 |
55312 | RFK | P65T-E | Human | Esophagus | ESCC | 5.66e-04 | 7.47e-02 | 0.0978 |
55312 | RFK | P74T-E | Human | Esophagus | ESCC | 1.92e-15 | 5.34e-01 | 0.1479 |
55312 | RFK | P75T-E | Human | Esophagus | ESCC | 1.71e-22 | 4.88e-01 | 0.1125 |
55312 | RFK | P76T-E | Human | Esophagus | ESCC | 1.55e-14 | 2.97e-01 | 0.1207 |
55312 | RFK | P79T-E | Human | Esophagus | ESCC | 1.36e-13 | 3.31e-01 | 0.1154 |
55312 | RFK | P80T-E | Human | Esophagus | ESCC | 1.67e-21 | 6.09e-01 | 0.155 |
55312 | RFK | P82T-E | Human | Esophagus | ESCC | 3.56e-14 | 8.60e-01 | 0.1072 |
55312 | RFK | P83T-E | Human | Esophagus | ESCC | 1.78e-23 | 7.72e-01 | 0.1738 |
55312 | RFK | P91T-E | Human | Esophagus | ESCC | 6.37e-08 | 9.05e-01 | 0.1828 |
55312 | RFK | P94T-E | Human | Esophagus | ESCC | 1.91e-03 | 5.75e-01 | 0.0879 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009260 | Colorectum | AD | ribonucleotide biosynthetic process | 66/3918 | 182/18723 | 1.25e-06 | 4.02e-05 | 66 |
GO:0046390 | Colorectum | AD | ribose phosphate biosynthetic process | 67/3918 | 190/18723 | 3.21e-06 | 9.05e-05 | 67 |
GO:1901293 | Colorectum | AD | nucleoside phosphate biosynthetic process | 80/3918 | 256/18723 | 6.31e-05 | 1.05e-03 | 80 |
GO:0009165 | Colorectum | AD | nucleotide biosynthetic process | 79/3918 | 254/18723 | 8.33e-05 | 1.30e-03 | 79 |
GO:0072593 | Colorectum | AD | reactive oxygen species metabolic process | 73/3918 | 239/18723 | 2.79e-04 | 3.42e-03 | 73 |
GO:0051353 | Colorectum | AD | positive regulation of oxidoreductase activity | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00092591 | Colorectum | SER | ribonucleotide metabolic process | 104/2897 | 385/18723 | 3.27e-09 | 3.04e-07 | 104 |
GO:00196931 | Colorectum | SER | ribose phosphate metabolic process | 105/2897 | 396/18723 | 8.15e-09 | 7.14e-07 | 105 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00725931 | Colorectum | SER | reactive oxygen species metabolic process | 61/2897 | 239/18723 | 3.63e-05 | 9.39e-04 | 61 |
GO:00092601 | Colorectum | SER | ribonucleotide biosynthetic process | 49/2897 | 182/18723 | 4.85e-05 | 1.19e-03 | 49 |
GO:00463901 | Colorectum | SER | ribose phosphate biosynthetic process | 50/2897 | 190/18723 | 7.70e-05 | 1.72e-03 | 50 |
GO:00091651 | Colorectum | SER | nucleotide biosynthetic process | 58/2897 | 254/18723 | 1.21e-03 | 1.38e-02 | 58 |
GO:19012931 | Colorectum | SER | nucleoside phosphate biosynthetic process | 58/2897 | 256/18723 | 1.47e-03 | 1.59e-02 | 58 |
GO:0051341 | Colorectum | SER | regulation of oxidoreductase activity | 27/2897 | 107/18723 | 5.86e-03 | 4.29e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RFK | SNV | Missense_Mutation | novel | c.299N>C | p.Val100Ala | p.V100A | Q969G6 | protein_coding | tolerated(0.12) | benign(0.099) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RFK | SNV | Missense_Mutation | novel | c.446N>A | p.Ser149Asn | p.S149N | Q969G6 | protein_coding | tolerated(0.48) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RFK | SNV | Missense_Mutation | novel | c.330N>A | p.Asp110Glu | p.D110E | Q969G6 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RFK | SNV | Missense_Mutation | novel | c.202N>G | p.Asn68Asp | p.N68D | Q969G6 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RFK | SNV | Missense_Mutation | c.321N>T | p.Lys107Asn | p.K107N | Q969G6 | protein_coding | tolerated(0.09) | possibly_damaging(0.702) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
RFK | SNV | Missense_Mutation | novel | c.239N>T | p.Thr80Ile | p.T80I | Q969G6 | protein_coding | tolerated(0.23) | possibly_damaging(0.851) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RFK | SNV | Missense_Mutation | novel | c.410N>C | p.Lys137Thr | p.K137T | Q969G6 | protein_coding | deleterious(0.02) | possibly_damaging(0.618) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RFK | SNV | Missense_Mutation | novel | c.402N>C | p.Glu134Asp | p.E134D | Q969G6 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RFK | SNV | Missense_Mutation | novel | c.43G>A | p.Gly15Ser | p.G15S | Q969G6 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-DD-AADW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RFK | SNV | Missense_Mutation | c.154N>T | p.Ser52Cys | p.S52C | Q969G6 | protein_coding | tolerated(0.34) | possibly_damaging(0.446) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55312 | RFK | KINASE, ENZYME | escitalopram | ESCITALOPRAM | ||
55312 | RFK | KINASE, ENZYME | citalopram | CITALOPRAM |
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