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Gene: REV1 |
Gene summary for REV1 |
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Gene information | Species | Human | Gene symbol | REV1 | Gene ID | 51455 |
Gene name | REV1 DNA directed polymerase | |
Gene Alias | AIBP80 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q9UBZ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51455 | REV1 | F034 | Human | Colorectum | FAP | 2.15e-20 | -9.04e-02 | -0.0665 |
51455 | REV1 | F072B | Human | Colorectum | FAP | 5.38e-08 | -2.12e-01 | 0.257 |
51455 | REV1 | CRC-1-8810 | Human | Colorectum | CRC | 1.43e-05 | -1.47e-01 | 0.6257 |
51455 | REV1 | CRC-3-11773 | Human | Colorectum | CRC | 2.26e-08 | -1.38e-01 | 0.2564 |
51455 | REV1 | LZE2T | Human | Esophagus | ESCC | 2.36e-03 | 3.94e-01 | 0.082 |
51455 | REV1 | LZE4T | Human | Esophagus | ESCC | 8.63e-07 | 2.24e-01 | 0.0811 |
51455 | REV1 | LZE7T | Human | Esophagus | ESCC | 6.66e-05 | 2.30e-01 | 0.0667 |
51455 | REV1 | LZE20T | Human | Esophagus | ESCC | 2.85e-02 | 2.11e-01 | 0.0662 |
51455 | REV1 | LZE22T | Human | Esophagus | ESCC | 1.84e-06 | 5.53e-01 | 0.068 |
51455 | REV1 | LZE24T | Human | Esophagus | ESCC | 2.98e-12 | 3.47e-01 | 0.0596 |
51455 | REV1 | LZE21T | Human | Esophagus | ESCC | 1.33e-08 | 5.71e-01 | 0.0655 |
51455 | REV1 | P1T-E | Human | Esophagus | ESCC | 1.71e-17 | 6.42e-01 | 0.0875 |
51455 | REV1 | P2T-E | Human | Esophagus | ESCC | 9.84e-22 | 5.89e-01 | 0.1177 |
51455 | REV1 | P4T-E | Human | Esophagus | ESCC | 2.25e-23 | 7.25e-01 | 0.1323 |
51455 | REV1 | P5T-E | Human | Esophagus | ESCC | 3.55e-16 | 3.44e-01 | 0.1327 |
51455 | REV1 | P8T-E | Human | Esophagus | ESCC | 1.37e-18 | 4.53e-01 | 0.0889 |
51455 | REV1 | P9T-E | Human | Esophagus | ESCC | 5.77e-15 | 3.85e-01 | 0.1131 |
51455 | REV1 | P10T-E | Human | Esophagus | ESCC | 3.36e-19 | 5.05e-01 | 0.116 |
51455 | REV1 | P11T-E | Human | Esophagus | ESCC | 6.72e-13 | 5.85e-01 | 0.1426 |
51455 | REV1 | P12T-E | Human | Esophagus | ESCC | 1.94e-26 | 4.45e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071897 | Colorectum | AD | DNA biosynthetic process | 55/3918 | 180/18723 | 1.46e-03 | 1.24e-02 | 55 |
GO:00718971 | Colorectum | SER | DNA biosynthetic process | 43/2897 | 180/18723 | 1.99e-03 | 1.98e-02 | 43 |
GO:00718972 | Colorectum | MSS | DNA biosynthetic process | 50/3467 | 180/18723 | 1.45e-03 | 1.35e-02 | 50 |
GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:00063012 | Esophagus | ESCC | postreplication repair | 26/8552 | 31/18723 | 1.32e-05 | 1.21e-04 | 26 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:0019985 | Esophagus | ESCC | translesion synthesis | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:00093147 | Lung | IAC | response to radiation | 77/2061 | 456/18723 | 8.59e-05 | 1.74e-03 | 77 |
GO:000931411 | Lung | AIS | response to radiation | 71/1849 | 456/18723 | 7.33e-05 | 1.91e-03 | 71 |
GO:00094162 | Lung | AIS | response to light stimulus | 47/1849 | 320/18723 | 3.72e-03 | 3.48e-02 | 47 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:00094114 | Oral cavity | OSCC | response to UV | 99/7305 | 149/18723 | 1.01e-11 | 3.70e-10 | 99 |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:00718979 | Oral cavity | OSCC | DNA biosynthetic process | 106/7305 | 180/18723 | 4.86e-08 | 8.95e-07 | 106 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
GO:00063011 | Oral cavity | OSCC | postreplication repair | 20/7305 | 31/18723 | 3.57e-03 | 1.49e-02 | 20 |
GO:000941112 | Oral cavity | LP | response to UV | 63/4623 | 149/18723 | 1.74e-06 | 4.05e-05 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REV1 | SNV | Missense_Mutation | c.3368N>A | p.Pro1123His | p.P1123H | Q9UBZ9 | protein_coding | tolerated(0.14) | benign(0.315) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REV1 | SNV | Missense_Mutation | c.3382N>G | p.Leu1128Val | p.L1128V | Q9UBZ9 | protein_coding | tolerated(0.32) | benign(0.039) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
REV1 | SNV | Missense_Mutation | c.2005N>A | p.Gly669Arg | p.G669R | Q9UBZ9 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
REV1 | SNV | Missense_Mutation | c.731C>T | p.Pro244Leu | p.P244L | Q9UBZ9 | protein_coding | tolerated(0.06) | benign(0.343) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REV1 | SNV | Missense_Mutation | novel | c.451G>A | p.Glu151Lys | p.E151K | Q9UBZ9 | protein_coding | tolerated(0.12) | benign(0.063) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
REV1 | insertion | In_Frame_Ins | novel | c.630_631insCTGTGGTGGGCTCCACCCAGTTCGAGTTTCCGGGCTGTTTTGATT | p.Arg210_Lys211insLeuTrpTrpAlaProProSerSerSerPheArgAlaValLeuIle | p.R210_K211insLWWAPPSSSFRAVLI | Q9UBZ9 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
REV1 | insertion | Nonsense_Mutation | novel | c.517_518insTGTGATGCAGTCTTGAATGAGAAT | p.Lys173delinsMetTerCysSerLeuGluTerGluTer | p.K173delinsM*CSLE*E* | Q9UBZ9 | protein_coding | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | ||
REV1 | insertion | Nonsense_Mutation | novel | c.3049_3050insTTTTGCTTCCCTGAGGTATTTGCAAAT | p.Asp1017delinsValLeuLeuProTerGlyIleCysLysTyr | p.D1017delinsVLLP*GICKY | Q9UBZ9 | protein_coding | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
REV1 | deletion | Frame_Shift_Del | novel | c.3128delG | p.Gly1043AlafsTer22 | p.G1043Afs*22 | Q9UBZ9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
REV1 | deletion | Frame_Shift_Del | c.3235delN | p.Thr1079ProfsTer12 | p.T1079Pfs*12 | Q9UBZ9 | protein_coding | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51455 | REV1 | NA | cisplatin | CISPLATIN |
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