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Gene: RCL1 |
Gene summary for RCL1 |
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Gene information | Species | Human | Gene symbol | RCL1 | Gene ID | 10171 |
Gene name | RNA terminal phosphate cyclase like 1 | |
Gene Alias | RNAC | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | GO:0000447 | UniProtAcc | Q5VZU3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10171 | RCL1 | P65T-E | Human | Esophagus | ESCC | 1.02e-12 | 4.74e-02 | 0.0978 |
10171 | RCL1 | P74T-E | Human | Esophagus | ESCC | 1.59e-10 | 1.49e-01 | 0.1479 |
10171 | RCL1 | P75T-E | Human | Esophagus | ESCC | 2.09e-21 | 4.06e-01 | 0.1125 |
10171 | RCL1 | P76T-E | Human | Esophagus | ESCC | 4.85e-14 | 1.68e-01 | 0.1207 |
10171 | RCL1 | P79T-E | Human | Esophagus | ESCC | 2.98e-17 | 3.26e-01 | 0.1154 |
10171 | RCL1 | P80T-E | Human | Esophagus | ESCC | 6.11e-29 | 8.51e-01 | 0.155 |
10171 | RCL1 | P82T-E | Human | Esophagus | ESCC | 7.93e-04 | 4.98e-02 | 0.1072 |
10171 | RCL1 | P83T-E | Human | Esophagus | ESCC | 7.39e-17 | 5.14e-01 | 0.1738 |
10171 | RCL1 | P84T-E | Human | Esophagus | ESCC | 4.85e-03 | 5.82e-02 | 0.0933 |
10171 | RCL1 | P89T-E | Human | Esophagus | ESCC | 1.40e-06 | 6.55e-01 | 0.1752 |
10171 | RCL1 | P91T-E | Human | Esophagus | ESCC | 9.35e-08 | 1.60e+00 | 0.1828 |
10171 | RCL1 | P107T-E | Human | Esophagus | ESCC | 1.20e-23 | 5.07e-01 | 0.171 |
10171 | RCL1 | P126T-E | Human | Esophagus | ESCC | 6.21e-03 | 3.35e-01 | 0.1125 |
10171 | RCL1 | P127T-E | Human | Esophagus | ESCC | 2.83e-09 | 7.49e-03 | 0.0826 |
10171 | RCL1 | P128T-E | Human | Esophagus | ESCC | 1.30e-16 | 4.84e-01 | 0.1241 |
10171 | RCL1 | P130T-E | Human | Esophagus | ESCC | 7.19e-25 | 5.31e-01 | 0.1676 |
10171 | RCL1 | C04 | Human | Oral cavity | OSCC | 2.95e-12 | 6.06e-01 | 0.2633 |
10171 | RCL1 | C21 | Human | Oral cavity | OSCC | 6.65e-06 | 2.90e-01 | 0.2678 |
10171 | RCL1 | C30 | Human | Oral cavity | OSCC | 2.26e-26 | 1.21e+00 | 0.3055 |
10171 | RCL1 | C38 | Human | Oral cavity | OSCC | 1.52e-09 | 1.36e+00 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0098742 | Cervix | N_HPV | cell-cell adhesion via plasma-membrane adhesion molecules | 17/534 | 273/18723 | 2.26e-03 | 2.11e-02 | 17 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
GO:005080812 | Endometrium | EEC | synapse organization | 68/2168 | 426/18723 | 3.73e-03 | 2.49e-02 | 68 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00004623 | Esophagus | ESCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
GO:00004603 | Esophagus | ESCC | maturation of 5.8S rRNA | 30/8552 | 35/18723 | 1.07e-06 | 1.34e-05 | 30 |
GO:00004693 | Esophagus | ESCC | cleavage involved in rRNA processing | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:00004663 | Esophagus | ESCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 21/8552 | 24/18723 | 2.57e-05 | 2.17e-04 | 21 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00004783 | Esophagus | ESCC | endonucleolytic cleavage involved in rRNA processing | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00004793 | Esophagus | ESCC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCL1 | SNV | Missense_Mutation | c.277N>T | p.Arg93Cys | p.R93C | Q9Y2P8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |
RCL1 | SNV | Missense_Mutation | rs781574564 | c.877G>A | p.Val293Ile | p.V293I | Q9Y2P8 | protein_coding | tolerated(0.21) | benign(0.079) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
RCL1 | SNV | Missense_Mutation | rs745330205 | c.614N>T | p.Ala205Val | p.A205V | Q9Y2P8 | protein_coding | tolerated(0.09) | benign(0.053) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
RCL1 | SNV | Missense_Mutation | c.1057G>T | p.Gly353Trp | p.G353W | Q9Y2P8 | protein_coding | deleterious(0) | possibly_damaging(0.825) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
RCL1 | SNV | Missense_Mutation | c.353N>T | p.Arg118Leu | p.R118L | Q9Y2P8 | protein_coding | deleterious(0.03) | benign(0.044) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RCL1 | SNV | Missense_Mutation | c.712N>C | p.Ser238Pro | p.S238P | Q9Y2P8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F5-6861-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RCL1 | SNV | Missense_Mutation | rs142051884 | c.985N>T | p.Arg329Trp | p.R329W | Q9Y2P8 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RCL1 | SNV | Missense_Mutation | novel | c.289N>C | p.Tyr97His | p.Y97H | Q9Y2P8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RCL1 | SNV | Missense_Mutation | novel | c.32C>G | p.Ala11Gly | p.A11G | Q9Y2P8 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCL1 | SNV | Missense_Mutation | c.344T>C | p.Ile115Thr | p.I115T | Q9Y2P8 | protein_coding | tolerated(0.06) | possibly_damaging(0.606) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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