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Gene: RCAN3 |
Gene summary for RCAN3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RCAN3 | Gene ID | 11123 |
Gene name | RCAN family member 3 | |
Gene Alias | DSCR1L2 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024RAH2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11123 | RCAN3 | P56T-E | Human | Esophagus | ESCC | 1.07e-02 | 3.79e-01 | 0.1613 |
11123 | RCAN3 | P57T-E | Human | Esophagus | ESCC | 7.26e-16 | 4.35e-01 | 0.0926 |
11123 | RCAN3 | P61T-E | Human | Esophagus | ESCC | 1.31e-03 | 1.25e-01 | 0.099 |
11123 | RCAN3 | P62T-E | Human | Esophagus | ESCC | 2.65e-19 | 2.63e-01 | 0.1302 |
11123 | RCAN3 | P65T-E | Human | Esophagus | ESCC | 1.51e-16 | 3.03e-01 | 0.0978 |
11123 | RCAN3 | P74T-E | Human | Esophagus | ESCC | 8.46e-13 | 4.23e-01 | 0.1479 |
11123 | RCAN3 | P75T-E | Human | Esophagus | ESCC | 1.83e-10 | 2.49e-01 | 0.1125 |
11123 | RCAN3 | P76T-E | Human | Esophagus | ESCC | 2.11e-16 | 3.54e-01 | 0.1207 |
11123 | RCAN3 | P79T-E | Human | Esophagus | ESCC | 5.90e-07 | 1.38e-01 | 0.1154 |
11123 | RCAN3 | P80T-E | Human | Esophagus | ESCC | 1.85e-25 | 6.21e-01 | 0.155 |
11123 | RCAN3 | P82T-E | Human | Esophagus | ESCC | 3.31e-16 | 7.09e-01 | 0.1072 |
11123 | RCAN3 | P83T-E | Human | Esophagus | ESCC | 1.37e-18 | 6.17e-01 | 0.1738 |
11123 | RCAN3 | P89T-E | Human | Esophagus | ESCC | 4.67e-09 | 6.07e-01 | 0.1752 |
11123 | RCAN3 | P104T-E | Human | Esophagus | ESCC | 5.97e-03 | 2.63e-01 | 0.0931 |
11123 | RCAN3 | P107T-E | Human | Esophagus | ESCC | 4.84e-21 | 4.37e-01 | 0.171 |
11123 | RCAN3 | P126T-E | Human | Esophagus | ESCC | 1.21e-09 | 7.82e-01 | 0.1125 |
11123 | RCAN3 | P127T-E | Human | Esophagus | ESCC | 2.83e-21 | 4.31e-01 | 0.0826 |
11123 | RCAN3 | P128T-E | Human | Esophagus | ESCC | 1.38e-21 | 6.88e-01 | 0.1241 |
11123 | RCAN3 | P130T-E | Human | Esophagus | ESCC | 1.04e-48 | 8.28e-01 | 0.1676 |
11123 | RCAN3 | C04 | Human | Oral cavity | OSCC | 6.79e-18 | 7.99e-01 | 0.2633 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCAN3 | SNV | Missense_Mutation | c.349N>G | p.Leu117Val | p.L117V | Q9UKA8 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
RCAN3 | SNV | Missense_Mutation | c.610N>A | p.Glu204Lys | p.E204K | Q9UKA8 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
RCAN3 | SNV | Missense_Mutation | rs777266872 | c.325G>A | p.Glu109Lys | p.E109K | Q9UKA8 | protein_coding | tolerated(0.4) | possibly_damaging(0.479) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RCAN3 | SNV | Missense_Mutation | novel | c.71A>G | p.Glu24Gly | p.E24G | Q9UKA8 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCAN3 | SNV | Missense_Mutation | novel | c.671N>T | p.Pro224Leu | p.P224L | Q9UKA8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCAN3 | SNV | Missense_Mutation | novel | c.23N>T | p.Ser8Phe | p.S8F | Q9UKA8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.603) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCAN3 | SNV | Missense_Mutation | rs553942744 | c.718N>A | p.Ala240Thr | p.A240T | Q9UKA8 | protein_coding | tolerated_low_confidence(0.53) | benign(0) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RCAN3 | SNV | Missense_Mutation | novel | c.211C>A | p.Leu71Ile | p.L71I | Q9UKA8 | protein_coding | deleterious(0.04) | possibly_damaging(0.817) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RCAN3 | SNV | Missense_Mutation | novel | c.470G>T | p.Trp157Leu | p.W157L | Q9UKA8 | protein_coding | deleterious(0.03) | benign(0.033) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
RCAN3 | SNV | Missense_Mutation | rs764690503 | c.488N>T | p.Ala163Val | p.A163V | Q9UKA8 | protein_coding | deleterious(0) | possibly_damaging(0.753) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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