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Gene: QKI |
Gene summary for QKI |
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Gene information | Species | Human | Gene symbol | QKI | Gene ID | 9444 |
Gene name | QKI, KH domain containing RNA binding | |
Gene Alias | Hqk | |
Cytomap | 6q26 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96PU8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9444 | QKI | P22T-E | Human | Esophagus | ESCC | 5.08e-10 | -1.79e-01 | 0.1236 |
9444 | QKI | P23T-E | Human | Esophagus | ESCC | 9.60e-14 | 1.92e-01 | 0.108 |
9444 | QKI | P24T-E | Human | Esophagus | ESCC | 3.04e-11 | 1.20e-01 | 0.1287 |
9444 | QKI | P26T-E | Human | Esophagus | ESCC | 2.91e-16 | 2.88e-01 | 0.1276 |
9444 | QKI | P27T-E | Human | Esophagus | ESCC | 3.66e-12 | -1.99e-02 | 0.1055 |
9444 | QKI | P28T-E | Human | Esophagus | ESCC | 2.05e-15 | 3.17e-01 | 0.1149 |
9444 | QKI | P30T-E | Human | Esophagus | ESCC | 3.47e-22 | 7.12e-01 | 0.137 |
9444 | QKI | P31T-E | Human | Esophagus | ESCC | 4.42e-18 | 1.18e-01 | 0.1251 |
9444 | QKI | P32T-E | Human | Esophagus | ESCC | 2.53e-23 | 4.09e-01 | 0.1666 |
9444 | QKI | P36T-E | Human | Esophagus | ESCC | 6.83e-17 | 2.63e-01 | 0.1187 |
9444 | QKI | P37T-E | Human | Esophagus | ESCC | 5.98e-15 | 3.52e-01 | 0.1371 |
9444 | QKI | P39T-E | Human | Esophagus | ESCC | 2.99e-14 | 4.50e-02 | 0.0894 |
9444 | QKI | P40T-E | Human | Esophagus | ESCC | 6.97e-05 | 1.04e-01 | 0.109 |
9444 | QKI | P42T-E | Human | Esophagus | ESCC | 4.09e-11 | 6.82e-02 | 0.1175 |
9444 | QKI | P44T-E | Human | Esophagus | ESCC | 6.21e-08 | 6.23e-02 | 0.1096 |
9444 | QKI | P47T-E | Human | Esophagus | ESCC | 4.49e-14 | 2.75e-02 | 0.1067 |
9444 | QKI | P48T-E | Human | Esophagus | ESCC | 1.22e-09 | 7.97e-02 | 0.0959 |
9444 | QKI | P49T-E | Human | Esophagus | ESCC | 2.90e-03 | 5.67e-01 | 0.1768 |
9444 | QKI | P52T-E | Human | Esophagus | ESCC | 1.78e-13 | 9.50e-02 | 0.1555 |
9444 | QKI | P54T-E | Human | Esophagus | ESCC | 1.95e-12 | 7.74e-02 | 0.0975 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004348410 | Cervix | CC | regulation of RNA splicing | 42/2311 | 148/18723 | 1.25e-07 | 6.24e-06 | 42 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:004802410 | Cervix | CC | regulation of mRNA splicing, via spliceosome | 28/2311 | 101/18723 | 2.41e-05 | 4.19e-04 | 28 |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506849 | Cervix | CC | regulation of mRNA processing | 33/2311 | 137/18723 | 1.06e-04 | 1.35e-03 | 33 |
GO:00015704 | Cervix | CC | vasculogenesis | 22/2311 | 80/18723 | 1.97e-04 | 2.26e-03 | 22 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:000037710 | Cervix | CC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000039810 | Cervix | CC | mRNA splicing, via spliceosome | 55/2311 | 320/18723 | 6.71e-03 | 3.70e-02 | 55 |
GO:000037510 | Cervix | CC | RNA splicing, via transesterification reactions | 55/2311 | 324/18723 | 8.61e-03 | 4.44e-02 | 55 |
GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
GO:004348416 | Endometrium | AEH | regulation of RNA splicing | 55/2100 | 148/18723 | 1.28e-16 | 5.49e-14 | 55 |
GO:000037515 | Endometrium | AEH | RNA splicing, via transesterification reactions | 88/2100 | 324/18723 | 1.11e-15 | 3.91e-13 | 88 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
QKI | SNV | Missense_Mutation | c.766N>G | p.Arg256Gly | p.R256G | Q96PU8 | protein_coding | tolerated(0.4) | benign(0.351) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QKI | SNV | Missense_Mutation | rs777858938 | c.956N>A | p.Arg319Gln | p.R319Q | Q96PU8 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
QKI | SNV | Missense_Mutation | c.169N>C | p.Tyr57His | p.Y57H | Q96PU8 | protein_coding | deleterious(0) | possibly_damaging(0.827) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
QKI | SNV | Missense_Mutation | c.938C>T | p.Ala313Val | p.A313V | Q96PU8 | protein_coding | deleterious(0.01) | benign(0.119) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
QKI | SNV | Missense_Mutation | novel | c.640N>T | p.Leu214Phe | p.L214F | Q96PU8 | protein_coding | tolerated(0.36) | benign(0.24) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
QKI | SNV | Missense_Mutation | c.889N>A | p.Ala297Thr | p.A297T | Q96PU8 | protein_coding | tolerated(0.16) | possibly_damaging(0.78) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
QKI | SNV | Missense_Mutation | rs777858938 | c.956N>A | p.Arg319Gln | p.R319Q | Q96PU8 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
QKI | SNV | Missense_Mutation | rs779943694 | c.989G>A | p.Arg330Lys | p.R330K | Q96PU8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.991) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
QKI | SNV | Missense_Mutation | rs142647102 | c.725N>A | p.Arg242His | p.R242H | Q96PU8 | protein_coding | tolerated(0.06) | possibly_damaging(0.769) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD |
QKI | SNV | Missense_Mutation | c.1000N>A | p.Ala334Thr | p.A334T | Q96PU8 | protein_coding | tolerated_low_confidence(0.49) | probably_damaging(0.972) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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