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Gene: PVRL4 |
Gene summary for PVRL4 |
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Gene information | Species | Human | Gene symbol | PVRL4 | Gene ID | 81607 |
Gene name | nectin cell adhesion molecule 4 | |
Gene Alias | EDSS1 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | K4PZ75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81607 | PVRL4 | P76T-E | Human | Esophagus | ESCC | 1.35e-23 | 5.26e-01 | 0.1207 |
81607 | PVRL4 | P79T-E | Human | Esophagus | ESCC | 7.31e-14 | 3.65e-01 | 0.1154 |
81607 | PVRL4 | P80T-E | Human | Esophagus | ESCC | 2.49e-69 | 2.01e+00 | 0.155 |
81607 | PVRL4 | P82T-E | Human | Esophagus | ESCC | 1.13e-23 | 1.34e+00 | 0.1072 |
81607 | PVRL4 | P83T-E | Human | Esophagus | ESCC | 1.40e-12 | 4.82e-01 | 0.1738 |
81607 | PVRL4 | P84T-E | Human | Esophagus | ESCC | 3.72e-20 | 1.70e+00 | 0.0933 |
81607 | PVRL4 | P89T-E | Human | Esophagus | ESCC | 3.05e-17 | 9.85e-01 | 0.1752 |
81607 | PVRL4 | P104T-E | Human | Esophagus | ESCC | 4.14e-03 | 3.17e-01 | 0.0931 |
81607 | PVRL4 | P107T-E | Human | Esophagus | ESCC | 3.37e-36 | 8.34e-01 | 0.171 |
81607 | PVRL4 | P126T-E | Human | Esophagus | ESCC | 8.67e-14 | 1.32e+00 | 0.1125 |
81607 | PVRL4 | P127T-E | Human | Esophagus | ESCC | 8.31e-58 | 1.20e+00 | 0.0826 |
81607 | PVRL4 | P128T-E | Human | Esophagus | ESCC | 1.15e-70 | 2.01e+00 | 0.1241 |
81607 | PVRL4 | P130T-E | Human | Esophagus | ESCC | 1.82e-62 | 1.16e+00 | 0.1676 |
81607 | PVRL4 | C21 | Human | Oral cavity | OSCC | 2.17e-11 | 9.86e-01 | 0.2678 |
81607 | PVRL4 | C38 | Human | Oral cavity | OSCC | 2.08e-16 | 1.18e+00 | 0.172 |
81607 | PVRL4 | C43 | Human | Oral cavity | OSCC | 1.44e-51 | 1.17e+00 | 0.1704 |
81607 | PVRL4 | C46 | Human | Oral cavity | OSCC | 4.33e-24 | 5.96e-01 | 0.1673 |
81607 | PVRL4 | C57 | Human | Oral cavity | OSCC | 7.79e-59 | 1.80e+00 | 0.1679 |
81607 | PVRL4 | C08 | Human | Oral cavity | OSCC | 8.09e-26 | 8.66e-01 | 0.1919 |
81607 | PVRL4 | C86 | Human | Oral cavity | OSCC | 9.62e-04 | 1.11e+00 | 0.161 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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