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Gene: PSMD1 |
Gene summary for PSMD1 |
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Gene information | Species | Human | Gene symbol | PSMD1 | Gene ID | 5707 |
Gene name | proteasome 26S subunit, non-ATPase 1 | |
Gene Alias | P112 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q99460 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5707 | PSMD1 | P9T-E | Human | Esophagus | ESCC | 6.03e-27 | 6.53e-01 | 0.1131 |
5707 | PSMD1 | P10T-E | Human | Esophagus | ESCC | 1.32e-29 | 6.03e-01 | 0.116 |
5707 | PSMD1 | P11T-E | Human | Esophagus | ESCC | 1.48e-28 | 1.19e+00 | 0.1426 |
5707 | PSMD1 | P12T-E | Human | Esophagus | ESCC | 1.43e-45 | 9.45e-01 | 0.1122 |
5707 | PSMD1 | P15T-E | Human | Esophagus | ESCC | 2.77e-41 | 1.13e+00 | 0.1149 |
5707 | PSMD1 | P16T-E | Human | Esophagus | ESCC | 2.85e-43 | 8.32e-01 | 0.1153 |
5707 | PSMD1 | P17T-E | Human | Esophagus | ESCC | 1.59e-13 | 7.39e-01 | 0.1278 |
5707 | PSMD1 | P19T-E | Human | Esophagus | ESCC | 1.84e-13 | 1.12e+00 | 0.1662 |
5707 | PSMD1 | P20T-E | Human | Esophagus | ESCC | 7.71e-29 | 7.35e-01 | 0.1124 |
5707 | PSMD1 | P21T-E | Human | Esophagus | ESCC | 2.61e-65 | 1.52e+00 | 0.1617 |
5707 | PSMD1 | P22T-E | Human | Esophagus | ESCC | 5.64e-45 | 9.13e-01 | 0.1236 |
5707 | PSMD1 | P23T-E | Human | Esophagus | ESCC | 1.50e-27 | 7.98e-01 | 0.108 |
5707 | PSMD1 | P24T-E | Human | Esophagus | ESCC | 6.80e-40 | 9.73e-01 | 0.1287 |
5707 | PSMD1 | P26T-E | Human | Esophagus | ESCC | 3.46e-26 | 7.05e-01 | 0.1276 |
5707 | PSMD1 | P27T-E | Human | Esophagus | ESCC | 3.24e-30 | 7.71e-01 | 0.1055 |
5707 | PSMD1 | P28T-E | Human | Esophagus | ESCC | 1.58e-33 | 9.08e-01 | 0.1149 |
5707 | PSMD1 | P30T-E | Human | Esophagus | ESCC | 1.49e-34 | 1.47e+00 | 0.137 |
5707 | PSMD1 | P31T-E | Human | Esophagus | ESCC | 7.44e-54 | 9.97e-01 | 0.1251 |
5707 | PSMD1 | P32T-E | Human | Esophagus | ESCC | 1.71e-67 | 1.43e+00 | 0.1666 |
5707 | PSMD1 | P36T-E | Human | Esophagus | ESCC | 1.25e-29 | 9.29e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:00421764 | Colorectum | FAP | regulation of protein catabolic process | 106/2622 | 391/18723 | 5.00e-12 | 3.06e-09 | 106 |
GO:00431614 | Colorectum | FAP | proteasome-mediated ubiquitin-dependent protein catabolic process | 98/2622 | 412/18723 | 5.41e-08 | 4.20e-06 | 98 |
GO:00104984 | Colorectum | FAP | proteasomal protein catabolic process | 110/2622 | 490/18723 | 2.12e-07 | 1.26e-05 | 110 |
GO:0048863 | Colorectum | FAP | stem cell differentiation | 44/2622 | 206/18723 | 2.48e-03 | 1.96e-02 | 44 |
GO:00421765 | Colorectum | CRC | regulation of protein catabolic process | 87/2078 | 391/18723 | 1.30e-10 | 6.49e-08 | 87 |
GO:00431615 | Colorectum | CRC | proteasome-mediated ubiquitin-dependent protein catabolic process | 69/2078 | 412/18723 | 3.16e-04 | 4.90e-03 | 69 |
GO:00104985 | Colorectum | CRC | proteasomal protein catabolic process | 77/2078 | 490/18723 | 1.03e-03 | 1.21e-02 | 77 |
GO:00488635 | Endometrium | AEH | stem cell differentiation | 40/2100 | 206/18723 | 3.67e-04 | 3.99e-03 | 40 |
GO:001049817 | Endometrium | EEC | proteasomal protein catabolic process | 112/2168 | 490/18723 | 6.99e-13 | 1.40e-10 | 112 |
GO:004316117 | Endometrium | EEC | proteasome-mediated ubiquitin-dependent protein catabolic process | 92/2168 | 412/18723 | 3.01e-10 | 3.23e-08 | 92 |
GO:004886314 | Endometrium | EEC | stem cell differentiation | 43/2168 | 206/18723 | 8.48e-05 | 1.21e-03 | 43 |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
GO:001049826 | Esophagus | HGIN | proteasomal protein catabolic process | 139/2587 | 490/18723 | 1.20e-17 | 3.41e-15 | 139 |
GO:004586227 | Esophagus | HGIN | positive regulation of proteolysis | 107/2587 | 372/18723 | 2.61e-14 | 4.60e-12 | 107 |
GO:004316126 | Esophagus | HGIN | proteasome-mediated ubiquitin-dependent protein catabolic process | 114/2587 | 412/18723 | 7.00e-14 | 1.20e-11 | 114 |
GO:190336227 | Esophagus | HGIN | regulation of cellular protein catabolic process | 81/2587 | 255/18723 | 1.16e-13 | 1.93e-11 | 81 |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa05020 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa03050 | Colorectum | AD | Proteasome | 29/2092 | 46/8465 | 3.87e-08 | 6.18e-07 | 3.94e-07 | 29 |
hsa05017 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050201 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa030501 | Colorectum | AD | Proteasome | 29/2092 | 46/8465 | 3.87e-08 | 6.18e-07 | 3.94e-07 | 29 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050128 | Colorectum | FAP | Parkinson disease | 80/1404 | 266/8465 | 2.04e-08 | 6.20e-07 | 3.77e-07 | 80 |
hsa050108 | Colorectum | FAP | Alzheimer disease | 105/1404 | 384/8465 | 3.74e-08 | 1.04e-06 | 6.33e-07 | 105 |
hsa050228 | Colorectum | FAP | Pathways of neurodegeneration - multiple diseases | 117/1404 | 476/8465 | 2.81e-06 | 4.47e-05 | 2.72e-05 | 117 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PSMD1 | SNV | Missense_Mutation | rs745401053 | c.164N>A | p.Arg55Gln | p.R55Q | Q99460 | protein_coding | tolerated(0.19) | benign(0) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
PSMD1 | SNV | Missense_Mutation | c.2809N>A | p.Glu937Lys | p.E937K | Q99460 | protein_coding | tolerated(0.74) | possibly_damaging(0.899) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PSMD1 | SNV | Missense_Mutation | c.2812N>A | p.Glu938Lys | p.E938K | Q99460 | protein_coding | tolerated(0.7) | possibly_damaging(0.899) | TCGA-BH-A0B5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR | |
PSMD1 | SNV | Missense_Mutation | c.2755N>C | p.Glu919Gln | p.E919Q | Q99460 | protein_coding | tolerated(0.14) | possibly_damaging(0.543) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
PSMD1 | SNV | Missense_Mutation | c.2098G>A | p.Glu700Lys | p.E700K | Q99460 | protein_coding | deleterious(0.02) | benign(0.141) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PSMD1 | SNV | Missense_Mutation | c.898N>C | p.Glu300Gln | p.E300Q | Q99460 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PSMD1 | SNV | Missense_Mutation | c.2177C>A | p.Ala726Asp | p.A726D | Q99460 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PSMD1 | insertion | Frame_Shift_Ins | novel | c.850dupA | p.Thr284AsnfsTer12 | p.T284Nfs*12 | Q99460 | protein_coding | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PSMD1 | insertion | Frame_Shift_Ins | novel | c.2407_2408insCTTTTCTT | p.Lys803ThrfsTer36 | p.K803Tfs*36 | Q99460 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PSMD1 | insertion | Frame_Shift_Ins | novel | c.268_269insC | p.Val90AlafsTer3 | p.V90Afs*3 | Q99460 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5707 | PSMD1 | NA | OPROZOMIB | OPROZOMIB | ||
5707 | PSMD1 | NA | inhibitor | CHEMBL325041 | BORTEZOMIB | |
5707 | PSMD1 | NA | inhibitor | CARFILZOMIB | CARFILZOMIB | |
5707 | PSMD1 | NA | BORTEZOMIB | BORTEZOMIB | 24524217 | |
5707 | PSMD1 | NA | inhibitor | CHEMBL2103884 | OPROZOMIB | |
5707 | PSMD1 | NA | BORTEZOMIB | BORTEZOMIB | ||
5707 | PSMD1 | NA | BORTEZOMIB | BORTEZOMIB | ||
5707 | PSMD1 | NA | CARFILZOMIB | CARFILZOMIB | 24524217 | |
5707 | PSMD1 | NA | MLN-9708 | IXAZOMIB CITRATE | ||
5707 | PSMD1 | NA | inhibitor | CHEMBL451887 | CARFILZOMIB |
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