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Gene: PPA1 |
Gene summary for PPA1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PPA1 | Gene ID | 5464 |
Gene name | inorganic pyrophosphatase 1 | |
Gene Alias | HEL-S-66p | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q15181 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5464 | PPA1 | Tumor | Human | Cervix | CC | 4.79e-10 | 3.80e-01 | 0.1241 |
5464 | PPA1 | sample3 | Human | Cervix | CC | 1.70e-09 | 2.97e-01 | 0.1387 |
5464 | PPA1 | L1 | Human | Cervix | CC | 5.34e-04 | -2.31e-01 | 0.0802 |
5464 | PPA1 | T3 | Human | Cervix | CC | 3.19e-13 | 3.22e-01 | 0.1389 |
5464 | PPA1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.91e-05 | 6.03e-01 | -0.0811 |
5464 | PPA1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.88e-07 | 6.19e-01 | -0.1088 |
5464 | PPA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.31e-06 | 3.64e-01 | -0.1954 |
5464 | PPA1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.48e-05 | 6.29e-01 | -0.059 |
5464 | PPA1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.53e-03 | 3.34e-01 | 0.096 |
5464 | PPA1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.96e-04 | 7.67e-01 | 0.0446 |
5464 | PPA1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.05e-10 | 1.21e+00 | 0.0171 |
5464 | PPA1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.18e-22 | 1.13e+00 | 0.294 |
5464 | PPA1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.35e-05 | 1.20e+00 | 0.3487 |
5464 | PPA1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.31e-13 | 8.44e-01 | 0.281 |
5464 | PPA1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.09e-31 | 1.31e+00 | 0.3859 |
5464 | PPA1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.19e-02 | 4.17e-01 | 0.3005 |
5464 | PPA1 | A015-C-203 | Human | Colorectum | FAP | 3.22e-08 | -9.94e-02 | -0.1294 |
5464 | PPA1 | A002-C-201 | Human | Colorectum | FAP | 1.80e-02 | -1.59e-01 | 0.0324 |
5464 | PPA1 | A001-C-119 | Human | Colorectum | FAP | 4.17e-02 | -2.61e-01 | -0.1557 |
5464 | PPA1 | A001-C-108 | Human | Colorectum | FAP | 5.53e-06 | -1.28e-01 | -0.0272 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0019033 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0019043 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0019053 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0019044 | Cervix | N_HPV | Oxidative phosphorylation | 25/349 | 134/8465 | 1.50e-10 | 6.81e-09 | 5.33e-09 | 25 |
hsa0019054 | Cervix | N_HPV | Oxidative phosphorylation | 25/349 | 134/8465 | 1.50e-10 | 6.81e-09 | 5.33e-09 | 25 |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa001902 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa001903 | Colorectum | SER | Oxidative phosphorylation | 79/1580 | 134/8465 | 1.98e-25 | 1.64e-23 | 1.19e-23 | 79 |
hsa001904 | Colorectum | MSS | Oxidative phosphorylation | 79/1875 | 134/8465 | 1.89e-20 | 7.90e-19 | 4.84e-19 | 79 |
hsa001905 | Colorectum | MSS | Oxidative phosphorylation | 79/1875 | 134/8465 | 1.89e-20 | 7.90e-19 | 4.84e-19 | 79 |
hsa001906 | Colorectum | MSI-H | Oxidative phosphorylation | 47/797 | 134/8465 | 2.13e-16 | 6.27e-15 | 5.26e-15 | 47 |
hsa001907 | Colorectum | MSI-H | Oxidative phosphorylation | 47/797 | 134/8465 | 2.13e-16 | 6.27e-15 | 5.26e-15 | 47 |
hsa001908 | Colorectum | FAP | Oxidative phosphorylation | 44/1404 | 134/8465 | 2.56e-06 | 4.28e-05 | 2.60e-05 | 44 |
hsa001909 | Colorectum | FAP | Oxidative phosphorylation | 44/1404 | 134/8465 | 2.56e-06 | 4.28e-05 | 2.60e-05 | 44 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPA1 | SNV | Missense_Mutation | c.550G>A | p.Glu184Lys | p.E184K | Q15181 | protein_coding | tolerated(0.29) | benign(0.03) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PPA1 | SNV | Missense_Mutation | c.159G>T | p.Trp53Cys | p.W53C | Q15181 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PPA1 | SNV | Missense_Mutation | rs777717226 | c.235N>T | p.Arg79Cys | p.R79C | Q15181 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPA1 | SNV | Missense_Mutation | rs867668532 | c.8G>A | p.Gly3Asp | p.G3D | Q15181 | protein_coding | tolerated(0.59) | benign(0.017) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PPA1 | SNV | Missense_Mutation | rs766193453 | c.559G>A | p.Val187Met | p.V187M | Q15181 | protein_coding | tolerated(0.11) | probably_damaging(0.912) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
PPA1 | SNV | Missense_Mutation | rs146821187 | c.412N>A | p.Val138Met | p.V138M | Q15181 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPA1 | SNV | Missense_Mutation | rs11538284 | c.457N>A | p.Asp153Asn | p.D153N | Q15181 | protein_coding | deleterious(0.02) | probably_damaging(0.915) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PPA1 | SNV | Missense_Mutation | c.701N>G | p.Lys234Arg | p.K234R | Q15181 | protein_coding | tolerated(0.08) | benign(0.03) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPA1 | SNV | Missense_Mutation | novel | c.310N>T | p.Pro104Ser | p.P104S | Q15181 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPA1 | SNV | Missense_Mutation | rs777717226 | c.235N>T | p.Arg79Cys | p.R79C | Q15181 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5464 | PPA1 | ENZYME | ETHANOL | ALCOHOL | 10349738 | |
5464 | PPA1 | ENZYME | GUANIDINIUM | 8639227 |
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