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Gene: POLR3K |
Gene summary for POLR3K |
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Gene information | Species | Human | Gene symbol | POLR3K | Gene ID | 51728 |
Gene name | RNA polymerase III subunit K | |
Gene Alias | C11 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9Y2Y1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51728 | POLR3K | P27T-E | Human | Esophagus | ESCC | 8.58e-20 | 4.68e-01 | 0.1055 |
51728 | POLR3K | P28T-E | Human | Esophagus | ESCC | 1.09e-26 | 6.02e-01 | 0.1149 |
51728 | POLR3K | P30T-E | Human | Esophagus | ESCC | 4.32e-18 | 7.63e-01 | 0.137 |
51728 | POLR3K | P31T-E | Human | Esophagus | ESCC | 9.69e-24 | 5.13e-01 | 0.1251 |
51728 | POLR3K | P32T-E | Human | Esophagus | ESCC | 2.77e-25 | 6.30e-01 | 0.1666 |
51728 | POLR3K | P36T-E | Human | Esophagus | ESCC | 7.53e-21 | 6.54e-01 | 0.1187 |
51728 | POLR3K | P37T-E | Human | Esophagus | ESCC | 2.05e-21 | 5.35e-01 | 0.1371 |
51728 | POLR3K | P39T-E | Human | Esophagus | ESCC | 1.28e-15 | 4.18e-01 | 0.0894 |
51728 | POLR3K | P40T-E | Human | Esophagus | ESCC | 3.50e-07 | 1.96e-01 | 0.109 |
51728 | POLR3K | P42T-E | Human | Esophagus | ESCC | 2.59e-12 | 4.15e-01 | 0.1175 |
51728 | POLR3K | P44T-E | Human | Esophagus | ESCC | 6.84e-04 | 1.60e-01 | 0.1096 |
51728 | POLR3K | P47T-E | Human | Esophagus | ESCC | 1.93e-16 | 3.63e-01 | 0.1067 |
51728 | POLR3K | P48T-E | Human | Esophagus | ESCC | 9.31e-13 | 3.12e-01 | 0.0959 |
51728 | POLR3K | P49T-E | Human | Esophagus | ESCC | 9.17e-04 | 9.83e-01 | 0.1768 |
51728 | POLR3K | P52T-E | Human | Esophagus | ESCC | 8.35e-39 | 9.02e-01 | 0.1555 |
51728 | POLR3K | P54T-E | Human | Esophagus | ESCC | 3.54e-38 | 9.33e-01 | 0.0975 |
51728 | POLR3K | P56T-E | Human | Esophagus | ESCC | 3.72e-03 | 5.11e-01 | 0.1613 |
51728 | POLR3K | P57T-E | Human | Esophagus | ESCC | 3.95e-11 | 2.42e-01 | 0.0926 |
51728 | POLR3K | P61T-E | Human | Esophagus | ESCC | 1.94e-08 | 2.51e-01 | 0.099 |
51728 | POLR3K | P62T-E | Human | Esophagus | ESCC | 1.51e-29 | 6.22e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00096157 | Breast | IDC | response to virus | 47/1434 | 367/18723 | 3.53e-04 | 5.16e-03 | 47 |
GO:000961512 | Breast | DCIS | response to virus | 45/1390 | 367/18723 | 6.16e-04 | 7.82e-03 | 45 |
GO:003447011 | Breast | DCIS | ncRNA processing | 44/1390 | 395/18723 | 4.56e-03 | 3.49e-02 | 44 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:00063532 | Esophagus | ESCC | DNA-templated transcription, termination | 15/8552 | 21/18723 | 1.54e-02 | 4.96e-02 | 15 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00311231 | Liver | HCC | RNA 3'-end processing | 81/7958 | 116/18723 | 2.27e-09 | 6.32e-08 | 81 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa046234 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0302031 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa0462311 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa030204 | Oral cavity | OSCC | RNA polymerase | 25/3704 | 34/8465 | 4.12e-04 | 1.27e-03 | 6.45e-04 | 25 |
hsa04623 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa0302011 | Oral cavity | OSCC | RNA polymerase | 25/3704 | 34/8465 | 4.12e-04 | 1.27e-03 | 6.45e-04 | 25 |
hsa046231 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa046232 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
hsa046233 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR3K | SNV | Missense_Mutation | rs144406744 | c.226N>T | p.Arg76Cys | p.R76C | Q9Y2Y1 | protein_coding | deleterious(0.03) | benign(0.111) | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |
POLR3K | SNV | Missense_Mutation | rs182344447 | c.314N>A | p.Arg105His | p.R105H | Q9Y2Y1 | protein_coding | deleterious(0.03) | benign(0.038) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
POLR3K | SNV | Missense_Mutation | rs867241220 | c.203N>T | p.Ser68Leu | p.S68L | Q9Y2Y1 | protein_coding | tolerated(0.26) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
POLR3K | SNV | Missense_Mutation | rs763310172 | c.227G>A | p.Arg76His | p.R76H | Q9Y2Y1 | protein_coding | tolerated(0.06) | benign(0.16) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLR3K | SNV | Missense_Mutation | rs745993040 | c.254N>A | p.Arg85His | p.R85H | Q9Y2Y1 | protein_coding | deleterious(0) | benign(0.2) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
POLR3K | SNV | Missense_Mutation | c.46N>A | p.Glu16Lys | p.E16K | Q9Y2Y1 | protein_coding | tolerated(0.29) | benign(0.162) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
POLR3K | SNV | Missense_Mutation | novel | c.148G>C | p.Asp50His | p.D50H | Q9Y2Y1 | protein_coding | deleterious(0.02) | benign(0.36) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLR3K | SNV | Missense_Mutation | rs144406744 | c.226C>T | p.Arg76Cys | p.R76C | Q9Y2Y1 | protein_coding | deleterious(0.03) | benign(0.111) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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