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Gene: POLR2M |
Gene summary for POLR2M |
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Gene information | Species | Human | Gene symbol | POLR2M | Gene ID | 81488 |
Gene name | RNA polymerase II subunit M | |
Gene Alias | GCOM1 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P0CAP1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81488 | POLR2M | P57T-E | Human | Esophagus | ESCC | 1.95e-03 | 1.06e-01 | 0.0926 |
81488 | POLR2M | P61T-E | Human | Esophagus | ESCC | 4.36e-11 | 2.62e-01 | 0.099 |
81488 | POLR2M | P62T-E | Human | Esophagus | ESCC | 1.25e-15 | 2.23e-01 | 0.1302 |
81488 | POLR2M | P65T-E | Human | Esophagus | ESCC | 4.18e-02 | 8.03e-02 | 0.0978 |
81488 | POLR2M | P74T-E | Human | Esophagus | ESCC | 4.89e-04 | 1.54e-01 | 0.1479 |
81488 | POLR2M | P75T-E | Human | Esophagus | ESCC | 8.23e-18 | 2.70e-01 | 0.1125 |
81488 | POLR2M | P76T-E | Human | Esophagus | ESCC | 2.68e-14 | 1.80e-01 | 0.1207 |
81488 | POLR2M | P79T-E | Human | Esophagus | ESCC | 3.43e-09 | 1.91e-01 | 0.1154 |
81488 | POLR2M | P80T-E | Human | Esophagus | ESCC | 2.92e-07 | 2.16e-01 | 0.155 |
81488 | POLR2M | P82T-E | Human | Esophagus | ESCC | 3.11e-11 | 4.98e-01 | 0.1072 |
81488 | POLR2M | P83T-E | Human | Esophagus | ESCC | 2.95e-08 | 3.44e-01 | 0.1738 |
81488 | POLR2M | P84T-E | Human | Esophagus | ESCC | 8.10e-04 | 2.24e-01 | 0.0933 |
81488 | POLR2M | P89T-E | Human | Esophagus | ESCC | 3.75e-09 | 5.59e-01 | 0.1752 |
81488 | POLR2M | P91T-E | Human | Esophagus | ESCC | 1.05e-08 | 8.55e-01 | 0.1828 |
81488 | POLR2M | P107T-E | Human | Esophagus | ESCC | 1.43e-13 | 3.75e-01 | 0.171 |
81488 | POLR2M | P126T-E | Human | Esophagus | ESCC | 1.52e-03 | 5.70e-01 | 0.1125 |
81488 | POLR2M | P127T-E | Human | Esophagus | ESCC | 3.40e-09 | 1.04e-01 | 0.0826 |
81488 | POLR2M | P128T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.31e-01 | 0.1241 |
81488 | POLR2M | P130T-E | Human | Esophagus | ESCC | 1.06e-43 | 7.84e-01 | 0.1676 |
81488 | POLR2M | HCC1_Meng | Human | Liver | HCC | 6.23e-40 | 8.26e-02 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:000702914 | Esophagus | ESCC | endoplasmic reticulum organization | 65/8552 | 87/18723 | 3.28e-08 | 6.08e-07 | 65 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:000702911 | Liver | HCC | endoplasmic reticulum organization | 64/7958 | 87/18723 | 3.92e-09 | 1.04e-07 | 64 |
GO:005123521 | Liver | HCC | maintenance of location | 185/7958 | 327/18723 | 1.70e-07 | 3.12e-06 | 185 |
GO:005165112 | Liver | HCC | maintenance of location in cell | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:0051657 | Liver | HCC | maintenance of organelle location | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
GO:005123518 | Oral cavity | OSCC | maintenance of location | 182/7305 | 327/18723 | 6.16e-10 | 1.58e-08 | 182 |
GO:005165120 | Oral cavity | OSCC | maintenance of location in cell | 121/7305 | 214/18723 | 1.39e-07 | 2.32e-06 | 121 |
GO:00070294 | Oral cavity | OSCC | endoplasmic reticulum organization | 58/7305 | 87/18723 | 1.59e-07 | 2.61e-06 | 58 |
GO:000702913 | Oral cavity | LP | endoplasmic reticulum organization | 41/4623 | 87/18723 | 4.49e-06 | 9.16e-05 | 41 |
GO:005123519 | Oral cavity | LP | maintenance of location | 111/4623 | 327/18723 | 9.62e-05 | 1.20e-03 | 111 |
GO:0051651110 | Oral cavity | LP | maintenance of location in cell | 74/4623 | 214/18723 | 7.18e-04 | 6.41e-03 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa0342032 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0302031 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa034202 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa03020 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa034203 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa030201 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa034204 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa030204 | Oral cavity | OSCC | RNA polymerase | 25/3704 | 34/8465 | 4.12e-04 | 1.27e-03 | 6.45e-04 | 25 |
hsa0342011 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa0302011 | Oral cavity | OSCC | RNA polymerase | 25/3704 | 34/8465 | 4.12e-04 | 1.27e-03 | 6.45e-04 | 25 |
hsa0342021 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030202 | Oral cavity | LP | RNA polymerase | 18/2418 | 34/8465 | 2.35e-03 | 1.03e-02 | 6.63e-03 | 18 |
hsa0342031 | Oral cavity | LP | Nucleotide excision repair | 37/2418 | 63/8465 | 5.14e-07 | 6.33e-06 | 4.08e-06 | 37 |
hsa030203 | Oral cavity | LP | RNA polymerase | 18/2418 | 34/8465 | 2.35e-03 | 1.03e-02 | 6.63e-03 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR2M | SNV | Missense_Mutation | novel | c.782C>T | p.Ser261Leu | p.S261L | P0CAP2 | protein_coding | deleterious(0.02) | benign(0.356) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLR2M | SNV | Missense_Mutation | rs760172634 | c.833N>A | p.Arg278Gln | p.R278Q | P0CAP2 | protein_coding | deleterious(0.04) | possibly_damaging(0.811) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
POLR2M | SNV | Missense_Mutation | c.1067C>T | p.Ser356Phe | p.S356F | P0CAP2 | nonsense_mediated_decay | unknown(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
POLR2M | SNV | Missense_Mutation | c.954G>T | p.Gln318His | p.Q318H | P0CAP2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
POLR2M | SNV | Missense_Mutation | novel | c.325N>G | p.Ser109Ala | p.S109A | P0CAP2 | protein_coding | deleterious(0.04) | possibly_damaging(0.477) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
POLR2M | SNV | Missense_Mutation | rs372856991 | c.601N>G | p.Ile201Val | p.I201V | P0CAP2 | protein_coding | tolerated(0.17) | benign(0.027) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
POLR2M | SNV | Missense_Mutation | rs546736463 | c.637N>A | p.Ala213Thr | p.A213T | P0CAP2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLR2M | SNV | Missense_Mutation | c.775N>C | p.Asn259His | p.N259H | P0CAP2 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
POLR2M | SNV | Missense_Mutation | c.700N>T | p.Val234Leu | p.V234L | P0CAP2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR2M | SNV | Missense_Mutation | rs375334112 | c.375N>C | p.Gln125His | p.Q125H | P0CAP2 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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