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Gene: PLA2R1 |
Gene summary for PLA2R1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PLA2R1 | Gene ID | 22925 |
| Gene name | phospholipase A2 receptor 1 | |
| Gene Alias | CLEC13C | |
| Cytomap | 2q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q13018 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 22925 | PLA2R1 | P79T-E | Human | Esophagus | ESCC | 2.15e-05 | 2.28e-01 | 0.1154 |
| 22925 | PLA2R1 | P80T-E | Human | Esophagus | ESCC | 1.19e-05 | 2.13e-01 | 0.155 |
| 22925 | PLA2R1 | P82T-E | Human | Esophagus | ESCC | 1.17e-07 | 6.87e-01 | 0.1072 |
| 22925 | PLA2R1 | P83T-E | Human | Esophagus | ESCC | 1.40e-07 | 4.24e-01 | 0.1738 |
| 22925 | PLA2R1 | P89T-E | Human | Esophagus | ESCC | 8.82e-03 | 4.65e-01 | 0.1752 |
| 22925 | PLA2R1 | P107T-E | Human | Esophagus | ESCC | 6.25e-12 | 3.67e-01 | 0.171 |
| 22925 | PLA2R1 | P127T-E | Human | Esophagus | ESCC | 5.91e-04 | 1.06e-01 | 0.0826 |
| 22925 | PLA2R1 | P130T-E | Human | Esophagus | ESCC | 2.96e-25 | 5.46e-01 | 0.1676 |
| 22925 | PLA2R1 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.29e-07 | -4.66e-01 | 0.02 |
| 22925 | PLA2R1 | PTCwithHT_1 | Human | Thyroid | HT | 2.29e-02 | -4.71e-01 | 0.0238 |
| 22925 | PLA2R1 | PTCwithHT_6 | Human | Thyroid | HT | 2.77e-07 | -4.71e-01 | 0.02 |
| 22925 | PLA2R1 | PTCwithHT_8 | Human | Thyroid | HT | 3.92e-04 | -4.58e-01 | 0.0351 |
| 22925 | PLA2R1 | PTCwithoutHT_2 | Human | Thyroid | PTC | 4.73e-06 | -4.54e-01 | 0.0419 |
| 22925 | PLA2R1 | male-WTA | Human | Thyroid | PTC | 1.26e-07 | -2.14e-01 | 0.1037 |
| 22925 | PLA2R1 | PTC01 | Human | Thyroid | PTC | 7.58e-13 | -3.97e-01 | 0.1899 |
| 22925 | PLA2R1 | PTC04 | Human | Thyroid | PTC | 7.26e-09 | -3.83e-01 | 0.1927 |
| 22925 | PLA2R1 | PTC06 | Human | Thyroid | PTC | 3.56e-05 | -1.99e-01 | 0.2057 |
| 22925 | PLA2R1 | PTC07 | Human | Thyroid | PTC | 1.74e-09 | -3.13e-01 | 0.2044 |
| 22925 | PLA2R1 | ATC09 | Human | Thyroid | ATC | 3.44e-05 | -2.95e-01 | 0.2871 |
| 22925 | PLA2R1 | ATC12 | Human | Thyroid | ATC | 8.03e-05 | -2.46e-01 | 0.34 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
| GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
| GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
| GO:0072331111 | Esophagus | ESCC | signal transduction by p53 class mediator | 121/8552 | 163/18723 | 9.61e-14 | 4.69e-12 | 121 |
| GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
| GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
| GO:1901796111 | Esophagus | ESCC | regulation of signal transduction by p53 class mediator | 70/8552 | 93/18723 | 5.69e-09 | 1.18e-07 | 70 |
| GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
| GO:0030330110 | Esophagus | ESCC | DNA damage response, signal transduction by p53 class mediator | 53/8552 | 72/18723 | 1.34e-06 | 1.63e-05 | 53 |
| GO:20010228 | Esophagus | ESCC | positive regulation of response to DNA damage stimulus | 69/8552 | 105/18723 | 2.66e-05 | 2.22e-04 | 69 |
| GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
| GO:0051346110 | Esophagus | ESCC | negative regulation of hydrolase activity | 208/8552 | 379/18723 | 1.76e-04 | 1.14e-03 | 208 |
| GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
| GO:00075699 | Esophagus | ESCC | cell aging | 81/8552 | 132/18723 | 2.00e-04 | 1.27e-03 | 81 |
| GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
| GO:1901798111 | Esophagus | ESCC | positive regulation of signal transduction by p53 class mediator | 18/8552 | 25/18723 | 7.04e-03 | 2.56e-02 | 18 |
| GO:004351615 | Esophagus | ESCC | regulation of DNA damage response, signal transduction by p53 class mediator | 23/8552 | 34/18723 | 8.06e-03 | 2.86e-02 | 23 |
| GO:00903984 | Esophagus | ESCC | cellular senescence | 54/8552 | 93/18723 | 1.08e-02 | 3.67e-02 | 54 |
| GO:19040197 | Esophagus | ESCC | epithelial cell apoptotic process | 68/8552 | 121/18723 | 1.27e-02 | 4.21e-02 | 68 |
| GO:000697930 | Thyroid | HT | response to oxidative stress | 81/1272 | 446/18723 | 2.53e-16 | 1.17e-13 | 81 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
| hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
| hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
| hsa0515212 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PLA2R1 | SNV | Missense_Mutation | c.2424N>A | p.Phe808Leu | p.F808L | Q13018 | protein_coding | tolerated(0.81) | benign(0.003) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
| PLA2R1 | SNV | Missense_Mutation | novel | c.3556N>C | p.Asp1186His | p.D1186H | Q13018 | protein_coding | deleterious(0.03) | possibly_damaging(0.866) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| PLA2R1 | SNV | Missense_Mutation | novel | c.3794N>A | p.Ser1265Tyr | p.S1265Y | Q13018 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLA2R1 | SNV | Missense_Mutation | rs757654265 | c.1487N>T | p.Arg496Ile | p.R496I | Q13018 | protein_coding | tolerated(0.07) | benign(0.049) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLA2R1 | SNV | Missense_Mutation | rs762241008 | c.1826N>C | p.His609Pro | p.H609P | Q13018 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-BH-A0BS-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
| PLA2R1 | SNV | Missense_Mutation | c.938N>G | p.Tyr313Cys | p.Y313C | Q13018 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | |
| PLA2R1 | SNV | Missense_Mutation | c.2059N>G | p.Leu687Val | p.L687V | Q13018 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| PLA2R1 | SNV | Missense_Mutation | novel | c.3919N>C | p.Gly1307Arg | p.G1307R | Q13018 | protein_coding | tolerated(0.19) | benign(0.027) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| PLA2R1 | SNV | Missense_Mutation | rs756774429 | c.1942N>A | p.Glu648Lys | p.E648K | Q13018 | protein_coding | tolerated(0.78) | benign(0) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| PLA2R1 | SNV | Missense_Mutation | c.2728C>G | p.Gln910Glu | p.Q910E | Q13018 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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