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Gene: PIK3IP1 |
Gene summary for PIK3IP1 |
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Gene information | Species | Human | Gene symbol | PIK3IP1 | Gene ID | 113791 |
Gene name | phosphoinositide-3-kinase interacting protein 1 | |
Gene Alias | HGFL | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q96FE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113791 | PIK3IP1 | P42T-E | Human | Esophagus | ESCC | 4.56e-07 | 2.57e-01 | 0.1175 |
113791 | PIK3IP1 | P44T-E | Human | Esophagus | ESCC | 9.59e-10 | 3.40e-01 | 0.1096 |
113791 | PIK3IP1 | P47T-E | Human | Esophagus | ESCC | 1.43e-08 | 4.03e-01 | 0.1067 |
113791 | PIK3IP1 | P48T-E | Human | Esophagus | ESCC | 2.71e-08 | 2.05e-01 | 0.0959 |
113791 | PIK3IP1 | P49T-E | Human | Esophagus | ESCC | 2.71e-04 | 5.27e-01 | 0.1768 |
113791 | PIK3IP1 | P52T-E | Human | Esophagus | ESCC | 8.44e-03 | 2.71e-01 | 0.1555 |
113791 | PIK3IP1 | P54T-E | Human | Esophagus | ESCC | 6.61e-03 | 1.14e-01 | 0.0975 |
113791 | PIK3IP1 | P57T-E | Human | Esophagus | ESCC | 6.84e-19 | 3.98e-01 | 0.0926 |
113791 | PIK3IP1 | P61T-E | Human | Esophagus | ESCC | 9.84e-14 | 4.76e-01 | 0.099 |
113791 | PIK3IP1 | P62T-E | Human | Esophagus | ESCC | 1.54e-20 | 5.37e-01 | 0.1302 |
113791 | PIK3IP1 | P65T-E | Human | Esophagus | ESCC | 2.00e-16 | 2.60e-01 | 0.0978 |
113791 | PIK3IP1 | P74T-E | Human | Esophagus | ESCC | 1.47e-13 | 6.09e-01 | 0.1479 |
113791 | PIK3IP1 | P75T-E | Human | Esophagus | ESCC | 5.11e-11 | 2.75e-01 | 0.1125 |
113791 | PIK3IP1 | P76T-E | Human | Esophagus | ESCC | 4.85e-05 | 1.74e-01 | 0.1207 |
113791 | PIK3IP1 | P79T-E | Human | Esophagus | ESCC | 6.71e-04 | 1.12e-01 | 0.1154 |
113791 | PIK3IP1 | P80T-E | Human | Esophagus | ESCC | 2.75e-15 | 5.95e-01 | 0.155 |
113791 | PIK3IP1 | P82T-E | Human | Esophagus | ESCC | 3.73e-05 | 7.53e-01 | 0.1072 |
113791 | PIK3IP1 | P83T-E | Human | Esophagus | ESCC | 5.59e-06 | 2.80e-01 | 0.1738 |
113791 | PIK3IP1 | P84T-E | Human | Esophagus | ESCC | 1.44e-09 | 6.01e-01 | 0.0933 |
113791 | PIK3IP1 | P107T-E | Human | Esophagus | ESCC | 1.45e-03 | 1.91e-01 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:00513481 | Colorectum | SER | negative regulation of transferase activity | 70/2897 | 268/18723 | 4.27e-06 | 1.62e-04 | 70 |
GO:00105631 | Colorectum | SER | negative regulation of phosphorus metabolic process | 101/2897 | 442/18723 | 2.39e-05 | 6.70e-04 | 101 |
GO:00459361 | Colorectum | SER | negative regulation of phosphate metabolic process | 100/2897 | 441/18723 | 3.62e-05 | 9.39e-04 | 100 |
GO:00423261 | Colorectum | SER | negative regulation of phosphorylation | 86/2897 | 385/18723 | 2.10e-04 | 3.78e-03 | 86 |
GO:00336731 | Colorectum | SER | negative regulation of kinase activity | 57/2897 | 237/18723 | 3.48e-04 | 5.46e-03 | 57 |
GO:00480171 | Colorectum | SER | inositol lipid-mediated signaling | 42/2897 | 182/18723 | 4.36e-03 | 3.49e-02 | 42 |
GO:00480151 | Colorectum | SER | phosphatidylinositol-mediated signaling | 41/2897 | 178/18723 | 4.97e-03 | 3.86e-02 | 41 |
GO:00513482 | Colorectum | MSS | negative regulation of transferase activity | 80/3467 | 268/18723 | 4.06e-06 | 1.17e-04 | 80 |
GO:00105632 | Colorectum | MSS | negative regulation of phosphorus metabolic process | 118/3467 | 442/18723 | 1.18e-05 | 2.77e-04 | 118 |
GO:00459362 | Colorectum | MSS | negative regulation of phosphate metabolic process | 117/3467 | 441/18723 | 1.74e-05 | 3.84e-04 | 117 |
GO:00423262 | Colorectum | MSS | negative regulation of phosphorylation | 103/3467 | 385/18723 | 3.76e-05 | 7.17e-04 | 103 |
GO:00336732 | Colorectum | MSS | negative regulation of kinase activity | 66/3467 | 237/18723 | 2.63e-04 | 3.54e-03 | 66 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIK3IP1 | SNV | Missense_Mutation | rs758274140 | c.739C>T | p.Pro247Ser | p.P247S | Q96FE7 | protein_coding | tolerated(0.76) | benign(0.006) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIK3IP1 | SNV | Missense_Mutation | c.554N>A | p.Gly185Glu | p.G185E | Q96FE7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
PIK3IP1 | SNV | Missense_Mutation | novel | c.697N>A | p.Glu233Lys | p.E233K | Q96FE7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIK3IP1 | SNV | Missense_Mutation | rs376084730 | c.356N>T | p.Ala119Val | p.A119V | Q96FE7 | protein_coding | tolerated(0.27) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PIK3IP1 | SNV | Missense_Mutation | rs752850127 | c.428C>T | p.Ala143Val | p.A143V | Q96FE7 | protein_coding | tolerated(0.24) | benign(0.166) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
PIK3IP1 | SNV | Missense_Mutation | rs772737278 | c.548N>T | p.Ala183Val | p.A183V | Q96FE7 | protein_coding | tolerated(0.35) | benign(0) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIK3IP1 | SNV | Missense_Mutation | c.209N>A | p.Cys70Tyr | p.C70Y | Q96FE7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PIK3IP1 | SNV | Missense_Mutation | novel | c.110N>G | p.Gln37Arg | p.Q37R | Q96FE7 | protein_coding | tolerated(0.11) | benign(0.175) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PIK3IP1 | SNV | Missense_Mutation | novel | c.321N>T | p.Gln107His | p.Q107H | Q96FE7 | protein_coding | tolerated(0.08) | benign(0.365) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIK3IP1 | SNV | Missense_Mutation | novel | c.547N>A | p.Ala183Thr | p.A183T | Q96FE7 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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