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Gene: PIGBOS1 |
Gene summary for PIGBOS1 |
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Gene information | Species | Human | Gene symbol | PIGBOS1 | Gene ID | 101928527 |
Gene name | PIGB opposite strand 1 | |
Gene Alias | HP06981 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | A0A0B4J2F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
101928527 | PIGBOS1 | P54T-E | Human | Esophagus | ESCC | 3.98e-03 | 8.23e-02 | 0.0975 |
101928527 | PIGBOS1 | P56T-E | Human | Esophagus | ESCC | 2.98e-03 | 3.27e-01 | 0.1613 |
101928527 | PIGBOS1 | P57T-E | Human | Esophagus | ESCC | 2.97e-12 | 1.56e-01 | 0.0926 |
101928527 | PIGBOS1 | P61T-E | Human | Esophagus | ESCC | 2.50e-18 | 2.94e-01 | 0.099 |
101928527 | PIGBOS1 | P62T-E | Human | Esophagus | ESCC | 5.65e-22 | 2.36e-01 | 0.1302 |
101928527 | PIGBOS1 | P65T-E | Human | Esophagus | ESCC | 3.78e-13 | 1.89e-01 | 0.0978 |
101928527 | PIGBOS1 | P74T-E | Human | Esophagus | ESCC | 1.41e-17 | 4.20e-01 | 0.1479 |
101928527 | PIGBOS1 | P75T-E | Human | Esophagus | ESCC | 4.34e-24 | 3.68e-01 | 0.1125 |
101928527 | PIGBOS1 | P76T-E | Human | Esophagus | ESCC | 1.46e-18 | 3.25e-01 | 0.1207 |
101928527 | PIGBOS1 | P79T-E | Human | Esophagus | ESCC | 2.98e-15 | 2.06e-01 | 0.1154 |
101928527 | PIGBOS1 | P80T-E | Human | Esophagus | ESCC | 5.74e-22 | 5.12e-01 | 0.155 |
101928527 | PIGBOS1 | P82T-E | Human | Esophagus | ESCC | 1.20e-18 | 6.16e-01 | 0.1072 |
101928527 | PIGBOS1 | P83T-E | Human | Esophagus | ESCC | 1.09e-24 | 5.98e-01 | 0.1738 |
101928527 | PIGBOS1 | P84T-E | Human | Esophagus | ESCC | 1.48e-04 | 2.64e-01 | 0.0933 |
101928527 | PIGBOS1 | P89T-E | Human | Esophagus | ESCC | 3.91e-07 | 4.12e-01 | 0.1752 |
101928527 | PIGBOS1 | P91T-E | Human | Esophagus | ESCC | 2.85e-12 | 1.14e+00 | 0.1828 |
101928527 | PIGBOS1 | P104T-E | Human | Esophagus | ESCC | 2.68e-02 | 2.34e-01 | 0.0931 |
101928527 | PIGBOS1 | P107T-E | Human | Esophagus | ESCC | 6.65e-23 | 4.78e-01 | 0.171 |
101928527 | PIGBOS1 | P126T-E | Human | Esophagus | ESCC | 1.38e-04 | 3.48e-01 | 0.1125 |
101928527 | PIGBOS1 | P127T-E | Human | Esophagus | ESCC | 5.30e-15 | 2.05e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
GO:0006986111 | Esophagus | ESCC | response to unfolded protein | 107/8552 | 137/18723 | 7.01e-15 | 3.87e-13 | 107 |
GO:0035967111 | Esophagus | ESCC | cellular response to topologically incorrect protein | 90/8552 | 116/18723 | 1.94e-12 | 8.11e-11 | 90 |
GO:0034620111 | Esophagus | ESCC | cellular response to unfolded protein | 74/8552 | 96/18723 | 3.10e-10 | 8.66e-09 | 74 |
GO:003096818 | Esophagus | ESCC | endoplasmic reticulum unfolded protein response | 59/8552 | 74/18723 | 1.90e-09 | 4.36e-08 | 59 |
GO:1905897111 | Esophagus | ESCC | regulation of response to endoplasmic reticulum stress | 63/8552 | 82/18723 | 8.16e-09 | 1.66e-07 | 63 |
GO:190010110 | Esophagus | ESCC | regulation of endoplasmic reticulum unfolded protein response | 24/8552 | 30/18723 | 1.27e-04 | 8.67e-04 | 24 |
GO:00349767 | Liver | Cirrhotic | response to endoplasmic reticulum stress | 130/4634 | 256/18723 | 1.72e-19 | 3.86e-17 | 130 |
GO:00359667 | Liver | Cirrhotic | response to topologically incorrect protein | 91/4634 | 159/18723 | 2.07e-18 | 3.60e-16 | 91 |
GO:00069867 | Liver | Cirrhotic | response to unfolded protein | 79/4634 | 137/18723 | 1.99e-16 | 2.49e-14 | 79 |
GO:00359677 | Liver | Cirrhotic | cellular response to topologically incorrect protein | 64/4634 | 116/18723 | 2.20e-12 | 1.62e-10 | 64 |
GO:00346207 | Liver | Cirrhotic | cellular response to unfolded protein | 54/4634 | 96/18723 | 4.16e-11 | 2.42e-09 | 54 |
GO:00309686 | Liver | Cirrhotic | endoplasmic reticulum unfolded protein response | 43/4634 | 74/18723 | 9.86e-10 | 4.48e-08 | 43 |
GO:19058977 | Liver | Cirrhotic | regulation of response to endoplasmic reticulum stress | 46/4634 | 82/18723 | 1.28e-09 | 5.56e-08 | 46 |
GO:19001015 | Liver | Cirrhotic | regulation of endoplasmic reticulum unfolded protein response | 19/4634 | 30/18723 | 8.57e-06 | 1.27e-04 | 19 |
GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
GO:003596612 | Liver | HCC | response to topologically incorrect protein | 123/7958 | 159/18723 | 2.60e-19 | 3.44e-17 | 123 |
GO:000698612 | Liver | HCC | response to unfolded protein | 103/7958 | 137/18723 | 6.50e-15 | 4.48e-13 | 103 |
GO:003596712 | Liver | HCC | cellular response to topologically incorrect protein | 89/7958 | 116/18723 | 5.61e-14 | 3.39e-12 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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