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Gene: PCLO |
Gene summary for PCLO |
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Gene information | Species | Human | Gene symbol | PCLO | Gene ID | 27445 |
Gene name | piccolo presynaptic cytomatrix protein | |
Gene Alias | ACZ | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q9Y6V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27445 | PCLO | P32T-E | Human | Esophagus | ESCC | 1.22e-19 | 3.43e-01 | 0.1666 |
27445 | PCLO | P36T-E | Human | Esophagus | ESCC | 1.43e-08 | 3.35e-01 | 0.1187 |
27445 | PCLO | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 1.57e-01 | 0.1371 |
27445 | PCLO | P39T-E | Human | Esophagus | ESCC | 2.78e-12 | 2.31e-01 | 0.0894 |
27445 | PCLO | P40T-E | Human | Esophagus | ESCC | 1.70e-03 | 1.19e-01 | 0.109 |
27445 | PCLO | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 9.71e-02 | 0.1175 |
27445 | PCLO | P47T-E | Human | Esophagus | ESCC | 2.44e-10 | 1.78e-01 | 0.1067 |
27445 | PCLO | P48T-E | Human | Esophagus | ESCC | 1.18e-08 | 1.42e-01 | 0.0959 |
27445 | PCLO | P54T-E | Human | Esophagus | ESCC | 3.86e-09 | 2.50e-01 | 0.0975 |
27445 | PCLO | P56T-E | Human | Esophagus | ESCC | 1.75e-02 | 3.63e-01 | 0.1613 |
27445 | PCLO | P57T-E | Human | Esophagus | ESCC | 2.43e-09 | 2.31e-01 | 0.0926 |
27445 | PCLO | P61T-E | Human | Esophagus | ESCC | 4.08e-06 | 1.50e-01 | 0.099 |
27445 | PCLO | P62T-E | Human | Esophagus | ESCC | 1.20e-04 | 1.26e-01 | 0.1302 |
27445 | PCLO | P65T-E | Human | Esophagus | ESCC | 6.29e-13 | 2.61e-01 | 0.0978 |
27445 | PCLO | P74T-E | Human | Esophagus | ESCC | 3.33e-12 | 3.10e-01 | 0.1479 |
27445 | PCLO | P75T-E | Human | Esophagus | ESCC | 2.01e-19 | 2.88e-01 | 0.1125 |
27445 | PCLO | P76T-E | Human | Esophagus | ESCC | 1.67e-11 | 2.22e-01 | 0.1207 |
27445 | PCLO | P79T-E | Human | Esophagus | ESCC | 4.32e-13 | 2.57e-01 | 0.1154 |
27445 | PCLO | P82T-E | Human | Esophagus | ESCC | 4.14e-03 | 1.95e-01 | 0.1072 |
27445 | PCLO | P83T-E | Human | Esophagus | ESCC | 1.31e-15 | 3.38e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0034331 | Colorectum | AD | cell junction maintenance | 15/3918 | 35/18723 | 2.78e-03 | 2.09e-02 | 15 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04911 | Colorectum | FAP | Insulin secretion | 23/1404 | 86/8465 | 1.12e-02 | 3.92e-02 | 2.38e-02 | 23 |
hsa049111 | Colorectum | FAP | Insulin secretion | 23/1404 | 86/8465 | 1.12e-02 | 3.92e-02 | 2.38e-02 | 23 |
hsa049112 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
hsa049113 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCLO | SNV | Missense_Mutation | c.15101N>A | p.Arg5034Lys | p.R5034K | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PCLO | SNV | Missense_Mutation | rs750875114 | c.12861N>G | p.Ser4287Arg | p.S4287R | Q9Y6V0 | protein_coding | deleterious(0.01) | possibly_damaging(0.788) | TCGA-A8-A06R-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PCLO | SNV | Missense_Mutation | c.12059G>T | p.Ser4020Ile | p.S4020I | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCLO | SNV | Missense_Mutation | rs201095081 | c.12058A>G | p.Ser4020Gly | p.S4020G | Q9Y6V0 | protein_coding | tolerated(0.07) | benign(0.083) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | rs368056917 | c.2860N>A | p.Pro954Thr | p.P954T | Q9Y6V0 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | c.7667C>T | p.Ser2556Phe | p.S2556F | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A075-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | CR | |
PCLO | SNV | Missense_Mutation | c.15227G>A | p.Arg5076Gln | p.R5076Q | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PCLO | SNV | Missense_Mutation | c.12700G>C | p.Ala4234Pro | p.A4234P | Q9Y6V0 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
PCLO | SNV | Missense_Mutation | novel | c.2623T>C | p.Ser875Pro | p.S875P | Q9Y6V0 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | rs371995456 | c.13316N>A | p.Arg4439His | p.R4439H | Q9Y6V0 | protein_coding | tolerated(0.07) | possibly_damaging(0.643) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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