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Gene: PAX9 |
Gene summary for PAX9 |
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Gene information | Species | Human | Gene symbol | PAX9 | Gene ID | 5083 |
Gene name | paired box 9 | |
Gene Alias | STHAG3 | |
Cytomap | 14q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P55771 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5083 | PAX9 | P62T-E | Human | Esophagus | ESCC | 3.51e-43 | 8.66e-01 | 0.1302 |
5083 | PAX9 | P65T-E | Human | Esophagus | ESCC | 3.62e-14 | 1.96e-01 | 0.0978 |
5083 | PAX9 | P74T-E | Human | Esophagus | ESCC | 5.00e-15 | 5.39e-01 | 0.1479 |
5083 | PAX9 | P75T-E | Human | Esophagus | ESCC | 1.08e-74 | 1.59e+00 | 0.1125 |
5083 | PAX9 | P76T-E | Human | Esophagus | ESCC | 1.19e-08 | 1.31e-01 | 0.1207 |
5083 | PAX9 | P82T-E | Human | Esophagus | ESCC | 9.39e-04 | 1.05e+00 | 0.1072 |
5083 | PAX9 | P83T-E | Human | Esophagus | ESCC | 1.83e-14 | 1.45e-01 | 0.1738 |
5083 | PAX9 | P84T-E | Human | Esophagus | ESCC | 1.11e-25 | 2.16e+00 | 0.0933 |
5083 | PAX9 | P89T-E | Human | Esophagus | ESCC | 1.14e-06 | 6.19e-01 | 0.1752 |
5083 | PAX9 | P107T-E | Human | Esophagus | ESCC | 2.24e-15 | 4.32e-01 | 0.171 |
5083 | PAX9 | P126T-E | Human | Esophagus | ESCC | 2.05e-03 | 1.22e+00 | 0.1125 |
5083 | PAX9 | P127T-E | Human | Esophagus | ESCC | 2.60e-40 | 9.30e-01 | 0.0826 |
5083 | PAX9 | P128T-E | Human | Esophagus | ESCC | 2.55e-56 | 2.92e+00 | 0.1241 |
5083 | PAX9 | P130T-E | Human | Esophagus | ESCC | 5.98e-20 | 6.38e-01 | 0.1676 |
5083 | PAX9 | C21 | Human | Oral cavity | OSCC | 2.25e-08 | 4.63e-01 | 0.2678 |
5083 | PAX9 | C30 | Human | Oral cavity | OSCC | 2.07e-14 | 7.31e-01 | 0.3055 |
5083 | PAX9 | C43 | Human | Oral cavity | OSCC | 1.77e-24 | 5.40e-01 | 0.1704 |
5083 | PAX9 | C46 | Human | Oral cavity | OSCC | 1.55e-30 | 7.29e-01 | 0.1673 |
5083 | PAX9 | C57 | Human | Oral cavity | OSCC | 1.53e-44 | 1.43e+00 | 0.1679 |
5083 | PAX9 | C08 | Human | Oral cavity | OSCC | 1.04e-02 | 6.70e-02 | 0.1919 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00074926 | Esophagus | ESCC | endoderm development | 54/8552 | 77/18723 | 1.20e-05 | 1.12e-04 | 54 |
GO:00603242 | Esophagus | ESCC | face development | 34/8552 | 44/18723 | 1.90e-05 | 1.67e-04 | 34 |
GO:00101711 | Esophagus | ESCC | body morphogenesis | 30/8552 | 43/18723 | 1.21e-03 | 5.88e-03 | 30 |
GO:00603253 | Esophagus | ESCC | face morphogenesis | 21/8552 | 28/18723 | 1.57e-03 | 7.33e-03 | 21 |
GO:00603232 | Esophagus | ESCC | head morphogenesis | 22/8552 | 32/18723 | 7.12e-03 | 2.58e-02 | 22 |
GO:20000274 | Esophagus | ESCC | regulation of animal organ morphogenesis | 71/8552 | 125/18723 | 7.97e-03 | 2.84e-02 | 71 |
GO:00074925 | Oral cavity | OSCC | endoderm development | 47/7305 | 77/18723 | 7.40e-05 | 5.81e-04 | 47 |
GO:0060324 | Oral cavity | OSCC | face development | 28/7305 | 44/18723 | 8.15e-04 | 4.35e-03 | 28 |
GO:00603252 | Oral cavity | OSCC | face morphogenesis | 18/7305 | 28/18723 | 5.96e-03 | 2.27e-02 | 18 |
GO:0060323 | Oral cavity | OSCC | head morphogenesis | 19/7305 | 32/18723 | 1.56e-02 | 5.00e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAX9 | SNV | Missense_Mutation | c.1021N>G | p.Leu341Val | p.L341V | P55771 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.952) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAX9 | SNV | Missense_Mutation | novel | c.761N>G | p.Lys254Arg | p.K254R | P55771 | protein_coding | tolerated_low_confidence(0.08) | benign(0) | TCGA-B6-A401-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PAX9 | SNV | Missense_Mutation | novel | c.140N>A | p.Arg47Gln | p.R47Q | P55771 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAX9 | SNV | Missense_Mutation | novel | c.1000N>T | p.His334Tyr | p.H334Y | P55771 | protein_coding | deleterious_low_confidence(0) | benign(0.221) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PAX9 | SNV | Missense_Mutation | c.604C>A | p.Leu202Met | p.L202M | P55771 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAX9 | SNV | Missense_Mutation | c.239N>T | p.Thr80Ile | p.T80I | P55771 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-5403-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PAX9 | SNV | Missense_Mutation | rs748361932 | c.323N>T | p.Ala108Val | p.A108V | P55771 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PAX9 | SNV | Missense_Mutation | novel | c.599A>G | p.Asp200Gly | p.D200G | P55771 | protein_coding | tolerated(0.21) | probably_damaging(0.989) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAX9 | SNV | Missense_Mutation | novel | c.415C>A | p.His139Asn | p.H139N | P55771 | protein_coding | tolerated(0.31) | benign(0.014) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAX9 | SNV | Missense_Mutation | rs771366081 | c.959N>T | p.Ser320Leu | p.S320L | P55771 | protein_coding | tolerated_low_confidence(0.07) | benign(0.114) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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