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Gene: PARM1 |
Gene summary for PARM1 |
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Gene information | Species | Human | Gene symbol | PARM1 | Gene ID | 25849 |
Gene name | prostate androgen-regulated mucin-like protein 1 | |
Gene Alias | Cipar1 | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6UWI2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25849 | PARM1 | P76T-E | Human | Esophagus | ESCC | 9.96e-05 | 1.40e-01 | 0.1207 |
25849 | PARM1 | P84T-E | Human | Esophagus | ESCC | 2.07e-04 | 3.09e-01 | 0.0933 |
25849 | PARM1 | P107T-E | Human | Esophagus | ESCC | 4.23e-02 | 2.72e-02 | 0.171 |
25849 | PARM1 | P128T-E | Human | Esophagus | ESCC | 1.35e-15 | 5.32e-01 | 0.1241 |
25849 | PARM1 | TD9 | Human | Lung | IAC | 3.04e-05 | 1.86e-01 | 0.088 |
25849 | PARM1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 9.02e-03 | -1.43e-01 | 0.3371 |
25849 | PARM1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 6.92e-18 | 6.34e-01 | -0.2116 |
25849 | PARM1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.36e-04 | 3.72e-01 | -0.2107 |
25849 | PARM1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 4.94e-11 | 4.32e-01 | -0.2119 |
25849 | PARM1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.28e-27 | 7.04e-01 | -0.0166 |
25849 | PARM1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 8.93e-26 | 6.80e-01 | -0.0132 |
25849 | PARM1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.85e-30 | 7.13e-01 | -0.013 |
25849 | PARM1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 6.19e-22 | 6.50e-01 | -0.0121 |
25849 | PARM1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 5.01e-06 | 6.64e-01 | -0.0961 |
25849 | PARM1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.72e-08 | 5.28e-01 | -0.0876 |
25849 | PARM1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 6.64e-06 | 4.17e-01 | -0.0822 |
25849 | PARM1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 9.11e-05 | 3.33e-01 | -0.0809 |
25849 | PARM1 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 2.65e-07 | 3.25e-01 | -0.1688 |
25849 | PARM1 | 052099_1652-all-cells | Human | Prostate | BPH | 1.35e-02 | 2.45e-01 | 0.1038 |
25849 | PARM1 | Dong_P3 | Human | Prostate | Tumor | 1.70e-17 | 4.64e-01 | 0.0278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:2000573 | Colorectum | AD | positive regulation of DNA biosynthetic process | 28/3918 | 66/18723 | 6.35e-05 | 1.05e-03 | 28 |
GO:0051972 | Colorectum | AD | regulation of telomerase activity | 22/3918 | 47/18723 | 6.45e-05 | 1.07e-03 | 22 |
GO:0051973 | Colorectum | AD | positive regulation of telomerase activity | 17/3918 | 34/18723 | 1.59e-04 | 2.20e-03 | 17 |
GO:0071897 | Colorectum | AD | DNA biosynthetic process | 55/3918 | 180/18723 | 1.46e-03 | 1.24e-02 | 55 |
GO:20002781 | Colorectum | SER | regulation of DNA biosynthetic process | 33/2897 | 106/18723 | 3.83e-05 | 9.82e-04 | 33 |
GO:00510541 | Colorectum | SER | positive regulation of DNA metabolic process | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:20005731 | Colorectum | SER | positive regulation of DNA biosynthetic process | 22/2897 | 66/18723 | 2.44e-04 | 4.17e-03 | 22 |
GO:00718971 | Colorectum | SER | DNA biosynthetic process | 43/2897 | 180/18723 | 1.99e-03 | 1.98e-02 | 43 |
GO:00519721 | Colorectum | SER | regulation of telomerase activity | 15/2897 | 47/18723 | 3.68e-03 | 3.07e-02 | 15 |
GO:00510522 | Colorectum | MSS | regulation of DNA metabolic process | 108/3467 | 359/18723 | 5.86e-08 | 3.10e-06 | 108 |
GO:00510542 | Colorectum | MSS | positive regulation of DNA metabolic process | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
GO:00519722 | Colorectum | MSS | regulation of telomerase activity | 21/3467 | 47/18723 | 3.36e-05 | 6.56e-04 | 21 |
GO:20002782 | Colorectum | MSS | regulation of DNA biosynthetic process | 37/3467 | 106/18723 | 4.48e-05 | 8.28e-04 | 37 |
GO:20005732 | Colorectum | MSS | positive regulation of DNA biosynthetic process | 26/3467 | 66/18723 | 5.97e-05 | 1.04e-03 | 26 |
GO:00519731 | Colorectum | MSS | positive regulation of telomerase activity | 16/3467 | 34/18723 | 1.36e-04 | 2.04e-03 | 16 |
GO:00718972 | Colorectum | MSS | DNA biosynthetic process | 50/3467 | 180/18723 | 1.45e-03 | 1.35e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PARM1 | SNV | Missense_Mutation | rs531049471 | c.731N>T | p.Arg244Met | p.R244M | Q6UWI2 | protein_coding | tolerated(0.16) | benign(0.263) | TCGA-A2-A3XY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
PARM1 | SNV | Missense_Mutation | c.47N>T | p.Trp16Leu | p.W16L | Q6UWI2 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PARM1 | SNV | Missense_Mutation | novel | c.929N>T | p.Ser310Phe | p.S310F | Q6UWI2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
PARM1 | SNV | Missense_Mutation | c.314N>T | p.Ser105Leu | p.S105L | Q6UWI2 | protein_coding | tolerated(0.05) | benign(0.04) | TCGA-ZJ-AAX8-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
PARM1 | SNV | Missense_Mutation | c.155A>G | p.Asp52Gly | p.D52G | Q6UWI2 | protein_coding | tolerated(0.14) | benign(0.01) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PARM1 | SNV | Missense_Mutation | rs182618057 | c.95N>T | p.Pro32Leu | p.P32L | Q6UWI2 | protein_coding | tolerated(0.06) | benign(0.042) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PARM1 | SNV | Missense_Mutation | novel | c.115N>G | p.Thr39Ala | p.T39A | Q6UWI2 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PARM1 | SNV | Missense_Mutation | c.68N>T | p.Thr23Ile | p.T23I | Q6UWI2 | protein_coding | tolerated(0.11) | benign(0.049) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PARM1 | SNV | Missense_Mutation | rs199704472 | c.424N>A | p.Ala142Thr | p.A142T | Q6UWI2 | protein_coding | tolerated(0.24) | benign(0) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PARM1 | SNV | Missense_Mutation | novel | c.26T>G | p.Leu9Arg | p.L9R | Q6UWI2 | protein_coding | tolerated(0.07) | probably_damaging(0.917) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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