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Gene: NXN |
Gene summary for NXN |
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Gene information | Species | Human | Gene symbol | NXN | Gene ID | 64359 |
Gene name | nucleoredoxin | |
Gene Alias | NRX | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q6DKJ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64359 | NXN | P27T-E | Human | Esophagus | ESCC | 3.49e-16 | 3.19e-01 | 0.1055 |
64359 | NXN | P28T-E | Human | Esophagus | ESCC | 5.51e-11 | 3.27e-01 | 0.1149 |
64359 | NXN | P30T-E | Human | Esophagus | ESCC | 5.62e-15 | 4.33e-01 | 0.137 |
64359 | NXN | P31T-E | Human | Esophagus | ESCC | 2.64e-33 | 6.19e-01 | 0.1251 |
64359 | NXN | P32T-E | Human | Esophagus | ESCC | 6.82e-16 | 3.91e-01 | 0.1666 |
64359 | NXN | P36T-E | Human | Esophagus | ESCC | 2.85e-21 | 6.76e-01 | 0.1187 |
64359 | NXN | P37T-E | Human | Esophagus | ESCC | 2.87e-19 | 3.93e-01 | 0.1371 |
64359 | NXN | P38T-E | Human | Esophagus | ESCC | 6.51e-08 | 3.63e-01 | 0.127 |
64359 | NXN | P39T-E | Human | Esophagus | ESCC | 5.17e-10 | 2.72e-01 | 0.0894 |
64359 | NXN | P40T-E | Human | Esophagus | ESCC | 3.22e-11 | 3.10e-01 | 0.109 |
64359 | NXN | P42T-E | Human | Esophagus | ESCC | 4.79e-14 | 4.03e-01 | 0.1175 |
64359 | NXN | P44T-E | Human | Esophagus | ESCC | 3.77e-07 | 1.21e-01 | 0.1096 |
64359 | NXN | P47T-E | Human | Esophagus | ESCC | 6.02e-14 | 2.34e-01 | 0.1067 |
64359 | NXN | P48T-E | Human | Esophagus | ESCC | 2.00e-12 | 1.85e-01 | 0.0959 |
64359 | NXN | P49T-E | Human | Esophagus | ESCC | 1.53e-12 | 9.19e-01 | 0.1768 |
64359 | NXN | P52T-E | Human | Esophagus | ESCC | 2.04e-15 | 4.03e-01 | 0.1555 |
64359 | NXN | P54T-E | Human | Esophagus | ESCC | 1.98e-24 | 5.51e-01 | 0.0975 |
64359 | NXN | P56T-E | Human | Esophagus | ESCC | 7.88e-05 | 4.70e-01 | 0.1613 |
64359 | NXN | P57T-E | Human | Esophagus | ESCC | 5.53e-11 | 2.86e-01 | 0.0926 |
64359 | NXN | P61T-E | Human | Esophagus | ESCC | 2.27e-16 | 2.86e-01 | 0.099 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:003139610 | Cervix | CC | regulation of protein ubiquitination | 59/2311 | 210/18723 | 5.90e-10 | 7.51e-08 | 59 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:003139710 | Cervix | CC | negative regulation of protein ubiquitination | 28/2311 | 83/18723 | 3.32e-07 | 1.35e-05 | 28 |
GO:190332110 | Cervix | CC | negative regulation of protein modification by small protein conjugation or removal | 29/2311 | 95/18723 | 2.15e-06 | 6.55e-05 | 29 |
GO:00988699 | Cervix | CC | cellular oxidant detoxification | 30/2311 | 101/18723 | 2.72e-06 | 7.93e-05 | 30 |
GO:19907489 | Cervix | CC | cellular detoxification | 30/2311 | 116/18723 | 5.34e-05 | 7.94e-04 | 30 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:00972379 | Cervix | CC | cellular response to toxic substance | 31/2311 | 124/18723 | 8.09e-05 | 1.10e-03 | 31 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:00987549 | Cervix | CC | detoxification | 33/2311 | 152/18723 | 7.97e-04 | 7.00e-03 | 33 |
GO:00301784 | Cervix | CC | negative regulation of Wnt signaling pathway | 35/2311 | 170/18723 | 1.52e-03 | 1.17e-02 | 35 |
GO:190332016 | Endometrium | AEH | regulation of protein modification by small protein conjugation or removal | 67/2100 | 242/18723 | 1.10e-12 | 2.26e-10 | 67 |
GO:003139616 | Endometrium | AEH | regulation of protein ubiquitination | 57/2100 | 210/18723 | 1.24e-10 | 1.40e-08 | 57 |
GO:00301118 | Endometrium | AEH | regulation of Wnt signaling pathway | 71/2100 | 328/18723 | 3.31e-08 | 1.87e-06 | 71 |
GO:003139716 | Endometrium | AEH | negative regulation of protein ubiquitination | 28/2100 | 83/18723 | 4.36e-08 | 2.40e-06 | 28 |
GO:190332116 | Endometrium | AEH | negative regulation of protein modification by small protein conjugation or removal | 30/2100 | 95/18723 | 7.94e-08 | 4.04e-06 | 30 |
GO:00160558 | Endometrium | AEH | Wnt signaling pathway | 85/2100 | 444/18723 | 4.99e-07 | 1.97e-05 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXN | SNV | Missense_Mutation | novel | c.464N>A | p.Arg155Gln | p.R155Q | Q6DKJ4 | protein_coding | tolerated(0.21) | probably_damaging(0.945) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NXN | SNV | Missense_Mutation | c.600N>A | p.Phe200Leu | p.F200L | Q6DKJ4 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NXN | SNV | Missense_Mutation | novel | c.1165N>T | p.Pro389Ser | p.P389S | Q6DKJ4 | protein_coding | tolerated(0.22) | probably_damaging(0.999) | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NXN | SNV | Missense_Mutation | novel | c.1205N>T | p.Ala402Val | p.A402V | Q6DKJ4 | protein_coding | tolerated(0.12) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NXN | SNV | Missense_Mutation | c.383G>A | p.Arg128Gln | p.R128Q | Q6DKJ4 | protein_coding | deleterious(0.02) | benign(0.278) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NXN | SNV | Missense_Mutation | c.600N>A | p.Phe200Leu | p.F200L | Q6DKJ4 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NXN | SNV | Missense_Mutation | c.529C>T | p.Pro177Ser | p.P177S | Q6DKJ4 | protein_coding | tolerated(0.33) | probably_damaging(0.986) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NXN | SNV | Missense_Mutation | novel | c.1226N>G | p.Asp409Gly | p.D409G | Q6DKJ4 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NXN | SNV | Missense_Mutation | rs201764402 | c.604N>A | p.Ala202Thr | p.A202T | Q6DKJ4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
NXN | SNV | Missense_Mutation | novel | c.860T>C | p.Val287Ala | p.V287A | Q6DKJ4 | protein_coding | deleterious(0.03) | benign(0.197) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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