Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: NUP85

Gene summary for NUP85

Gene summary.

Gene information	Species	Human
	Gene symbol	NUP85
	Gene ID	79902
	Gene name	nucleoporin 85
	Gene Alias	FROUNT
	Cytomap	17q25.1
	Gene Type	protein-coding
	GO ID	GO:0001655
	UniProtAcc	Q9BW27

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
79902	NUP85	P54T-E	Human	Esophagus	ESCC	1.96e-12	1.45e-01	0.0975
79902	NUP85	P57T-E	Human	Esophagus	ESCC	1.54e-06	1.41e-01	0.0926
79902	NUP85	P61T-E	Human	Esophagus	ESCC	3.76e-16	2.70e-01	0.099
79902	NUP85	P62T-E	Human	Esophagus	ESCC	1.06e-13	3.45e-01	0.1302
79902	NUP85	P65T-E	Human	Esophagus	ESCC	1.84e-15	2.74e-01	0.0978
79902	NUP85	P74T-E	Human	Esophagus	ESCC	4.70e-14	4.56e-01	0.1479
79902	NUP85	P75T-E	Human	Esophagus	ESCC	1.26e-18	4.34e-01	0.1125
79902	NUP85	P76T-E	Human	Esophagus	ESCC	2.38e-18	3.52e-01	0.1207
79902	NUP85	P79T-E	Human	Esophagus	ESCC	8.82e-12	2.04e-01	0.1154
79902	NUP85	P80T-E	Human	Esophagus	ESCC	1.09e-16	5.41e-01	0.155
79902	NUP85	P82T-E	Human	Esophagus	ESCC	1.40e-04	4.01e-01	0.1072
79902	NUP85	P83T-E	Human	Esophagus	ESCC	1.92e-25	8.03e-01	0.1738
79902	NUP85	P84T-E	Human	Esophagus	ESCC	2.00e-02	3.01e-01	0.0933
79902	NUP85	P89T-E	Human	Esophagus	ESCC	2.06e-05	5.53e-01	0.1752
79902	NUP85	P91T-E	Human	Esophagus	ESCC	7.13e-08	1.05e+00	0.1828
79902	NUP85	P107T-E	Human	Esophagus	ESCC	2.18e-25	5.81e-01	0.171
79902	NUP85	P127T-E	Human	Esophagus	ESCC	2.59e-13	9.93e-02	0.0826
79902	NUP85	P128T-E	Human	Esophagus	ESCC	4.19e-15	4.98e-01	0.1241
79902	NUP85	P130T-E	Human	Esophagus	ESCC	3.56e-32	7.11e-01	0.1676
79902	NUP85	HCC1_Meng	Human	Liver	HCC	1.46e-25	-1.03e-02	0.0246

Page: 1 2 3 4 5

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:0072594110	Esophagus	ESCC	establishment of protein localization to organelle	311/8552	422/18723	3.02e-32	2.13e-29	311
GO:0006913110	Esophagus	ESCC	nucleocytoplasmic transport	230/8552	301/18723	6.04e-28	2.02e-25	230
GO:0051169110	Esophagus	ESCC	nuclear transport	230/8552	301/18723	6.04e-28	2.02e-25	230
GO:0006403110	Esophagus	ESCC	RNA localization	166/8552	201/18723	1.95e-27	6.18e-25	166
GO:003450418	Esophagus	ESCC	protein localization to nucleus	211/8552	290/18723	4.06e-21	6.60e-19	211
GO:005123617	Esophagus	ESCC	establishment of RNA localization	134/8552	166/18723	1.23e-20	1.81e-18	134
GO:0051168110	Esophagus	ESCC	nuclear export	126/8552	154/18723	1.88e-20	2.65e-18	126
GO:005102815	Esophagus	ESCC	mRNA transport	110/8552	130/18723	2.76e-20	3.80e-18	110
GO:005065717	Esophagus	ESCC	nucleic acid transport	131/8552	163/18723	6.94e-20	8.46e-18	131
GO:005065817	Esophagus	ESCC	RNA transport	131/8552	163/18723	6.94e-20	8.46e-18	131
GO:001593117	Esophagus	ESCC	nucleobase-containing compound transport	162/8552	222/18723	9.87e-17	7.93e-15	162
GO:001703818	Esophagus	ESCC	protein import	149/8552	206/18723	5.90e-15	3.31e-13	149
GO:007116612	Esophagus	ESCC	ribonucleoprotein complex localization	66/8552	77/18723	2.94e-13	1.38e-11	66
GO:007142612	Esophagus	ESCC	ribonucleoprotein complex export from nucleus	65/8552	76/18723	5.56e-13	2.50e-11	65
GO:000640512	Esophagus	ESCC	RNA export from nucleus	68/8552	84/18723	2.99e-11	1.01e-09	68
GO:00064064	Esophagus	ESCC	mRNA export from nucleus	51/8552	59/18723	7.98e-11	2.47e-09	51
GO:00714274	Esophagus	ESCC	mRNA-containing ribonucleoprotein complex export from nucleus	51/8552	59/18723	7.98e-11	2.47e-09	51
GO:005117014	Esophagus	ESCC	import into nucleus	111/8552	159/18723	5.69e-10	1.44e-08	111
GO:000660613	Esophagus	ESCC	protein import into nucleus	108/8552	155/18723	1.16e-09	2.77e-08	108
GO:003150314	Esophagus	ESCC	protein-containing complex localization	139/8552	220/18723	1.14e-07	1.85e-06	139

Page: 1 2 3 4 5 6

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa05014210	Esophagus	ESCC	Amyotrophic lateral sclerosis	266/4205	364/8465	1.31e-20	2.20e-18	1.13e-18	266
hsa0301321	Esophagus	ESCC	Nucleocytoplasmic transport	89/4205	108/8465	1.20e-12	2.37e-11	1.21e-11	89
hsa0501438	Esophagus	ESCC	Amyotrophic lateral sclerosis	266/4205	364/8465	1.31e-20	2.20e-18	1.13e-18	266
hsa0301331	Esophagus	ESCC	Nucleocytoplasmic transport	89/4205	108/8465	1.20e-12	2.37e-11	1.21e-11	89
hsa0501422	Liver	HCC	Amyotrophic lateral sclerosis	252/4020	364/8465	8.85e-18	7.41e-16	4.12e-16	252
hsa03013	Liver	HCC	Nucleocytoplasmic transport	81/4020	108/8465	4.28e-09	6.83e-08	3.80e-08	81
hsa0501432	Liver	HCC	Amyotrophic lateral sclerosis	252/4020	364/8465	8.85e-18	7.41e-16	4.12e-16	252
hsa030131	Liver	HCC	Nucleocytoplasmic transport	81/4020	108/8465	4.28e-09	6.83e-08	3.80e-08	81
hsa0501428	Oral cavity	OSCC	Amyotrophic lateral sclerosis	246/3704	364/8465	6.65e-21	1.11e-18	5.67e-19	246
hsa030136	Oral cavity	OSCC	Nucleocytoplasmic transport	82/3704	108/8465	7.93e-12	1.33e-10	6.77e-11	82
hsa05014112	Oral cavity	OSCC	Amyotrophic lateral sclerosis	246/3704	364/8465	6.65e-21	1.11e-18	5.67e-19	246
hsa0301311	Oral cavity	OSCC	Nucleocytoplasmic transport	82/3704	108/8465	7.93e-12	1.33e-10	6.77e-11	82
hsa0501429	Oral cavity	LP	Amyotrophic lateral sclerosis	197/2418	364/8465	1.25e-25	1.39e-23	8.93e-24	197
hsa030132	Oral cavity	LP	Nucleocytoplasmic transport	53/2418	108/8465	4.68e-06	4.10e-05	2.64e-05	53
hsa0501437	Oral cavity	LP	Amyotrophic lateral sclerosis	197/2418	364/8465	1.25e-25	1.39e-23	8.93e-24	197
hsa030133	Oral cavity	LP	Nucleocytoplasmic transport	53/2418	108/8465	4.68e-06	4.10e-05	2.64e-05	53

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

NUP85

SNV

Missense_Mutation

novel

c.1616G>T

p.Gly539Val

p.G539V

Q9BW27

protein_coding

deleterious(0.05)

probably_damaging(0.997)

TCGA-A2-A3XT-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cyclophosphamide

NUP85

SNV

Missense_Mutation

novel

c.224N>T

p.Ser75Phe

p.S75F

Q9BW27

protein_coding

deleterious(0)

possibly_damaging(0.792)

TCGA-BH-A0HF-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

arimidex

NUP85

SNV

Missense_Mutation

c.827N>T

p.Thr276Ile

p.T276I

Q9BW27

protein_coding

deleterious(0)

benign(0.112)

TCGA-BH-A0HF-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

arimidex

NUP85

SNV

Missense_Mutation

novel

c.673N>T

p.Ala225Ser

p.A225S

Q9BW27

protein_coding

tolerated(0.84)

benign(0.001)

TCGA-S3-AA10-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

cytoxan

NUP85

insertion

Frame_Shift_Ins

novel

c.1748_1749insTTTTAAT

p.Leu584PhefsTer18

p.L584Ffs*18

Q9BW27

protein_coding

TCGA-A2-A0EQ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

NUP85

insertion

Nonsense_Mutation

novel

c.1749_1750insCATGACTCTTGTTATGTATTTTGA

p.Pro583_Leu584insHisAspSerCysTyrValPheTer

p.P583_L584insHDSCYVF*

Q9BW27

protein_coding

TCGA-A2-A0EQ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

NUP85

deletion

In_Frame_Del

c.1692_1694delNNN

p.Thr565del

p.T565del

Q9BW27

protein_coding

TCGA-D8-A1XQ-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

NUP85

SNV

Missense_Mutation

c.13N>A

p.Asp5Asn

p.D5N

Q9BW27

protein_coding

deleterious_low_confidence(0)

probably_damaging(0.996)

TCGA-EK-A2RJ-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

NUP85

SNV

Missense_Mutation

c.320N>T

p.Ser107Leu

p.S107L

Q9BW27

protein_coding

deleterious(0)

possibly_damaging(0.826)

TCGA-IR-A3LA-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

NUP85

SNV

Missense_Mutation

c.234N>G

p.Ile78Met

p.I78M

Q9BW27

protein_coding

deleterious(0)

probably_damaging(0.979)

TCGA-Q1-A73R-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

Page: 1 2 3 4 5 6

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1