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Gene: NUB1 |
Gene summary for NUB1 |
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Gene information | Species | Human | Gene symbol | NUB1 | Gene ID | 51667 |
Gene name | negative regulator of ubiquitin like proteins 1 | |
Gene Alias | BS4 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | H3BM74 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51667 | NUB1 | P48T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.74e-01 | 0.0959 |
51667 | NUB1 | P49T-E | Human | Esophagus | ESCC | 1.85e-19 | 1.66e+00 | 0.1768 |
51667 | NUB1 | P52T-E | Human | Esophagus | ESCC | 1.11e-11 | 4.52e-01 | 0.1555 |
51667 | NUB1 | P54T-E | Human | Esophagus | ESCC | 1.13e-14 | 4.41e-01 | 0.0975 |
51667 | NUB1 | P56T-E | Human | Esophagus | ESCC | 3.04e-10 | 8.15e-01 | 0.1613 |
51667 | NUB1 | P57T-E | Human | Esophagus | ESCC | 4.41e-12 | 3.96e-01 | 0.0926 |
51667 | NUB1 | P61T-E | Human | Esophagus | ESCC | 1.48e-22 | 4.37e-01 | 0.099 |
51667 | NUB1 | P62T-E | Human | Esophagus | ESCC | 3.59e-38 | 7.17e-01 | 0.1302 |
51667 | NUB1 | P65T-E | Human | Esophagus | ESCC | 1.65e-19 | 3.87e-01 | 0.0978 |
51667 | NUB1 | P74T-E | Human | Esophagus | ESCC | 4.12e-37 | 1.08e+00 | 0.1479 |
51667 | NUB1 | P75T-E | Human | Esophagus | ESCC | 3.42e-51 | 1.13e+00 | 0.1125 |
51667 | NUB1 | P76T-E | Human | Esophagus | ESCC | 1.01e-10 | 3.15e-01 | 0.1207 |
51667 | NUB1 | P79T-E | Human | Esophagus | ESCC | 8.59e-19 | 4.61e-01 | 0.1154 |
51667 | NUB1 | P80T-E | Human | Esophagus | ESCC | 1.66e-54 | 1.51e+00 | 0.155 |
51667 | NUB1 | P82T-E | Human | Esophagus | ESCC | 7.74e-19 | 8.91e-01 | 0.1072 |
51667 | NUB1 | P83T-E | Human | Esophagus | ESCC | 3.85e-32 | 8.24e-01 | 0.1738 |
51667 | NUB1 | P84T-E | Human | Esophagus | ESCC | 2.02e-07 | 5.74e-01 | 0.0933 |
51667 | NUB1 | P89T-E | Human | Esophagus | ESCC | 4.52e-18 | 1.14e+00 | 0.1752 |
51667 | NUB1 | P91T-E | Human | Esophagus | ESCC | 2.42e-20 | 1.50e+00 | 0.1828 |
51667 | NUB1 | P104T-E | Human | Esophagus | ESCC | 6.83e-03 | 3.86e-01 | 0.0931 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:0032434111 | Esophagus | ESCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 107/8552 | 134/18723 | 4.06e-16 | 2.93e-14 | 107 |
GO:2000058111 | Esophagus | ESCC | regulation of ubiquitin-dependent protein catabolic process | 125/8552 | 164/18723 | 1.17e-15 | 7.76e-14 | 125 |
GO:1903364111 | Esophagus | ESCC | positive regulation of cellular protein catabolic process | 117/8552 | 155/18723 | 3.25e-14 | 1.66e-12 | 117 |
GO:1901800110 | Esophagus | ESCC | positive regulation of proteasomal protein catabolic process | 91/8552 | 114/18723 | 6.74e-14 | 3.34e-12 | 91 |
GO:1903052110 | Esophagus | ESCC | positive regulation of proteolysis involved in cellular protein catabolic process | 101/8552 | 133/18723 | 9.58e-13 | 4.19e-11 | 101 |
GO:0032436111 | Esophagus | ESCC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 72/8552 | 90/18723 | 2.30e-11 | 7.87e-10 | 72 |
GO:2000060111 | Esophagus | ESCC | positive regulation of ubiquitin-dependent protein catabolic process | 81/8552 | 107/18723 | 2.23e-10 | 6.34e-09 | 81 |
GO:003461220 | Esophagus | ESCC | response to tumor necrosis factor | 149/8552 | 253/18723 | 1.47e-05 | 1.33e-04 | 149 |
GO:00343418 | Esophagus | ESCC | response to interferon-gamma | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUB1 | SNV | Missense_Mutation | c.1849N>C | p.Asp617His | p.D617H | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NUB1 | SNV | Missense_Mutation | novel | c.1792N>A | p.Glu598Lys | p.E598K | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
NUB1 | insertion | In_Frame_Ins | novel | c.1866_1867insACACGG | p.Ile622_Ala623insThrArg | p.I622_A623insTR | protein_coding | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
NUB1 | insertion | Frame_Shift_Ins | novel | c.1869dupA | p.Glu624ArgfsTer9 | p.E624Rfs*9 | protein_coding | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
NUB1 | SNV | Missense_Mutation | c.683T>G | p.Val228Gly | p.V228G | protein_coding | tolerated(0.31) | benign(0.138) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
NUB1 | SNV | Missense_Mutation | novel | c.1870G>A | p.Glu624Lys | p.E624K | protein_coding | tolerated(0.44) | benign(0.045) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NUB1 | SNV | Missense_Mutation | rs373576077 | c.1118G>A | p.Arg373Gln | p.R373Q | protein_coding | tolerated(0.33) | benign(0.014) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NUB1 | SNV | Missense_Mutation | novel | c.265T>G | p.Cys89Gly | p.C89G | protein_coding | deleterious(0.02) | benign(0.425) | TCGA-AA-A00O-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NUB1 | SNV | Missense_Mutation | rs373576077 | c.1118G>A | p.Arg373Gln | p.R373Q | protein_coding | tolerated(0.33) | benign(0.014) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
NUB1 | SNV | Missense_Mutation | rs868105409 | c.1784C>T | p.Ala595Val | p.A595V | protein_coding | tolerated(1) | possibly_damaging(0.804) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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