![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NPDC1 |
Gene summary for NPDC1 |
![]() |
Gene information | Species | Human | Gene symbol | NPDC1 | Gene ID | 56654 |
Gene name | neural proliferation, differentiation and control 1 | |
Gene Alias | CAB | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NQX5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56654 | NPDC1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 9.88e-20 | -2.68e-01 | -0.1875 |
56654 | NPDC1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.77e-27 | -3.72e-01 | -0.1883 |
56654 | NPDC1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.36e-28 | -2.20e-01 | -0.1934 |
56654 | NPDC1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.63e-42 | -3.95e-01 | -0.1917 |
56654 | NPDC1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.73e-36 | -3.96e-01 | -0.1916 |
56654 | NPDC1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 4.86e-05 | 1.03e-01 | -0.1269 |
56654 | NPDC1 | LZE4T | Human | Esophagus | ESCC | 1.17e-03 | -5.38e-02 | 0.0811 |
56654 | NPDC1 | LZE22D1 | Human | Esophagus | HGIN | 3.93e-02 | 1.10e-01 | 0.0595 |
56654 | NPDC1 | LZE24T | Human | Esophagus | ESCC | 5.13e-06 | 3.43e-01 | 0.0596 |
56654 | NPDC1 | P2T-E | Human | Esophagus | ESCC | 1.11e-02 | -2.68e-02 | 0.1177 |
56654 | NPDC1 | P4T-E | Human | Esophagus | ESCC | 8.85e-10 | 4.51e-01 | 0.1323 |
56654 | NPDC1 | P5T-E | Human | Esophagus | ESCC | 2.75e-20 | 4.46e-01 | 0.1327 |
56654 | NPDC1 | P8T-E | Human | Esophagus | ESCC | 1.99e-48 | 1.28e+00 | 0.0889 |
56654 | NPDC1 | P10T-E | Human | Esophagus | ESCC | 2.07e-19 | 4.19e-01 | 0.116 |
56654 | NPDC1 | P11T-E | Human | Esophagus | ESCC | 7.78e-10 | 7.20e-01 | 0.1426 |
56654 | NPDC1 | P15T-E | Human | Esophagus | ESCC | 2.27e-02 | 1.31e-01 | 0.1149 |
56654 | NPDC1 | P16T-E | Human | Esophagus | ESCC | 2.25e-33 | 6.24e-01 | 0.1153 |
56654 | NPDC1 | P17T-E | Human | Esophagus | ESCC | 3.86e-04 | 6.90e-01 | 0.1278 |
56654 | NPDC1 | P21T-E | Human | Esophagus | ESCC | 1.83e-02 | 3.66e-01 | 0.1617 |
56654 | NPDC1 | P22T-E | Human | Esophagus | ESCC | 7.19e-36 | 7.26e-01 | 0.1236 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPDC1 | SNV | Missense_Mutation | c.334N>A | p.Gly112Arg | p.G112R | Q9NQX5 | protein_coding | tolerated(0.48) | benign(0.213) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NPDC1 | SNV | Missense_Mutation | c.265N>A | p.Gly89Ser | p.G89S | Q9NQX5 | protein_coding | tolerated(0.82) | benign(0.054) | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
NPDC1 | SNV | Missense_Mutation | c.832G>C | p.Glu278Gln | p.E278Q | Q9NQX5 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
NPDC1 | insertion | Frame_Shift_Ins | novel | c.350_351insAAGA | p.Leu118ArgfsTer96 | p.L118Rfs*96 | Q9NQX5 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
NPDC1 | SNV | Missense_Mutation | rs778983633 | c.407G>A | p.Arg136Gln | p.R136Q | Q9NQX5 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | rs564238459 | c.406C>T | p.Arg136Trp | p.R136W | Q9NQX5 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
NPDC1 | SNV | Missense_Mutation | novel | c.141N>A | p.Asp47Glu | p.D47E | Q9NQX5 | protein_coding | tolerated(0.1) | benign(0.207) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | rs751469138 | c.445N>A | p.Gly149Arg | p.G149R | Q9NQX5 | protein_coding | deleterious(0.05) | probably_damaging(0.929) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
NPDC1 | SNV | Missense_Mutation | rs780477037 | c.928G>A | p.Ala310Thr | p.A310T | Q9NQX5 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | novel | c.742N>G | p.Met248Val | p.M248V | Q9NQX5 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |