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Gene: NOP14-AS1 |
Gene summary for NOP14-AS1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NOP14-AS1 | Gene ID | 317648 |
| Gene name | NOP14 antisense RNA 1 | |
| Gene Alias | C4orf10 | |
| Cytomap | 4p16.3 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 317648 | NOP14-AS1 | P75T-E | Human | Esophagus | ESCC | 1.59e-30 | 4.77e-01 | 0.1125 |
| 317648 | NOP14-AS1 | P76T-E | Human | Esophagus | ESCC | 2.27e-21 | 3.29e-01 | 0.1207 |
| 317648 | NOP14-AS1 | P79T-E | Human | Esophagus | ESCC | 1.66e-18 | 3.46e-01 | 0.1154 |
| 317648 | NOP14-AS1 | P80T-E | Human | Esophagus | ESCC | 3.25e-12 | 4.33e-01 | 0.155 |
| 317648 | NOP14-AS1 | P82T-E | Human | Esophagus | ESCC | 8.85e-06 | 4.95e-01 | 0.1072 |
| 317648 | NOP14-AS1 | P83T-E | Human | Esophagus | ESCC | 1.77e-26 | 7.59e-01 | 0.1738 |
| 317648 | NOP14-AS1 | P89T-E | Human | Esophagus | ESCC | 7.66e-15 | 8.53e-01 | 0.1752 |
| 317648 | NOP14-AS1 | P91T-E | Human | Esophagus | ESCC | 1.36e-03 | 4.19e-01 | 0.1828 |
| 317648 | NOP14-AS1 | P107T-E | Human | Esophagus | ESCC | 1.28e-39 | 1.02e+00 | 0.171 |
| 317648 | NOP14-AS1 | P128T-E | Human | Esophagus | ESCC | 4.28e-09 | 2.79e-01 | 0.1241 |
| 317648 | NOP14-AS1 | P130T-E | Human | Esophagus | ESCC | 1.35e-23 | 4.35e-01 | 0.1676 |
| 317648 | NOP14-AS1 | C04 | Human | Oral cavity | OSCC | 2.02e-06 | 4.04e-01 | 0.2633 |
| 317648 | NOP14-AS1 | C21 | Human | Oral cavity | OSCC | 1.32e-47 | 1.24e+00 | 0.2678 |
| 317648 | NOP14-AS1 | C30 | Human | Oral cavity | OSCC | 4.51e-26 | 1.05e+00 | 0.3055 |
| 317648 | NOP14-AS1 | C43 | Human | Oral cavity | OSCC | 7.87e-03 | 8.87e-02 | 0.1704 |
| 317648 | NOP14-AS1 | C46 | Human | Oral cavity | OSCC | 5.65e-04 | 1.75e-01 | 0.1673 |
| 317648 | NOP14-AS1 | C57 | Human | Oral cavity | OSCC | 1.23e-04 | 2.11e-01 | 0.1679 |
| 317648 | NOP14-AS1 | C08 | Human | Oral cavity | OSCC | 4.14e-10 | 1.75e-01 | 0.1919 |
| 317648 | NOP14-AS1 | SYSMH1 | Human | Oral cavity | OSCC | 2.40e-09 | 2.25e-01 | 0.1127 |
| 317648 | NOP14-AS1 | SYSMH2 | Human | Oral cavity | OSCC | 2.03e-17 | 4.10e-01 | 0.2326 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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