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Gene: NIT1 |
Gene summary for NIT1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NIT1 | Gene ID | 4817 |
Gene name | nitrilase 1 | |
Gene Alias | NIT1 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | Q86X76 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4817 | NIT1 | P48T-E | Human | Esophagus | ESCC | 1.70e-16 | 2.82e-01 | 0.0959 |
4817 | NIT1 | P49T-E | Human | Esophagus | ESCC | 2.26e-15 | 1.38e+00 | 0.1768 |
4817 | NIT1 | P52T-E | Human | Esophagus | ESCC | 3.50e-19 | 4.21e-01 | 0.1555 |
4817 | NIT1 | P54T-E | Human | Esophagus | ESCC | 6.92e-22 | 3.32e-01 | 0.0975 |
4817 | NIT1 | P56T-E | Human | Esophagus | ESCC | 1.60e-07 | 6.87e-01 | 0.1613 |
4817 | NIT1 | P57T-E | Human | Esophagus | ESCC | 1.41e-25 | 4.60e-01 | 0.0926 |
4817 | NIT1 | P61T-E | Human | Esophagus | ESCC | 7.72e-18 | 4.57e-01 | 0.099 |
4817 | NIT1 | P62T-E | Human | Esophagus | ESCC | 7.25e-50 | 7.84e-01 | 0.1302 |
4817 | NIT1 | P65T-E | Human | Esophagus | ESCC | 1.04e-22 | 3.53e-01 | 0.0978 |
4817 | NIT1 | P74T-E | Human | Esophagus | ESCC | 4.97e-32 | 8.69e-01 | 0.1479 |
4817 | NIT1 | P75T-E | Human | Esophagus | ESCC | 1.93e-38 | 6.27e-01 | 0.1125 |
4817 | NIT1 | P76T-E | Human | Esophagus | ESCC | 8.72e-38 | 6.56e-01 | 0.1207 |
4817 | NIT1 | P79T-E | Human | Esophagus | ESCC | 2.01e-25 | 4.07e-01 | 0.1154 |
4817 | NIT1 | P80T-E | Human | Esophagus | ESCC | 4.26e-29 | 6.54e-01 | 0.155 |
4817 | NIT1 | P82T-E | Human | Esophagus | ESCC | 1.13e-18 | 8.10e-01 | 0.1072 |
4817 | NIT1 | P83T-E | Human | Esophagus | ESCC | 6.07e-29 | 8.29e-01 | 0.1738 |
4817 | NIT1 | P84T-E | Human | Esophagus | ESCC | 2.18e-05 | 4.04e-01 | 0.0933 |
4817 | NIT1 | P89T-E | Human | Esophagus | ESCC | 2.49e-23 | 1.24e+00 | 0.1752 |
4817 | NIT1 | P91T-E | Human | Esophagus | ESCC | 8.48e-13 | 1.00e+00 | 0.1828 |
4817 | NIT1 | P107T-E | Human | Esophagus | ESCC | 9.23e-46 | 1.03e+00 | 0.171 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004427016 | Oral cavity | OSCC | cellular nitrogen compound catabolic process | 256/7305 | 451/18723 | 9.67e-15 | 5.88e-13 | 256 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIT1 | SNV | Missense_Mutation | rs760352516 | c.151N>A | p.Val51Met | p.V51M | Q86X76 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NIT1 | SNV | Missense_Mutation | c.859N>C | p.Glu287Gln | p.E287Q | Q86X76 | protein_coding | tolerated(0.06) | benign(0.041) | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NIT1 | SNV | Missense_Mutation | c.859N>C | p.Glu287Gln | p.E287Q | Q86X76 | protein_coding | tolerated(0.06) | benign(0.041) | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
NIT1 | SNV | Missense_Mutation | c.797N>T | p.Arg266Ile | p.R266I | Q86X76 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
NIT1 | SNV | Missense_Mutation | rs531981250 | c.541A>G | p.Thr181Ala | p.T181A | Q86X76 | protein_coding | deleterious(0.05) | possibly_damaging(0.665) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
NIT1 | SNV | Missense_Mutation | rs759711881 | c.415N>G | p.Thr139Ala | p.T139A | Q86X76 | protein_coding | tolerated(0.63) | benign(0.012) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIT1 | SNV | Missense_Mutation | novel | c.488N>T | p.His163Leu | p.H163L | Q86X76 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NIT1 | SNV | Missense_Mutation | c.387C>G | p.Phe129Leu | p.F129L | Q86X76 | protein_coding | tolerated(0.25) | benign(0.306) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NIT1 | SNV | Missense_Mutation | rs375048732 | c.917N>A | p.Arg306Gln | p.R306Q | Q86X76 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NIT1 | SNV | Missense_Mutation | c.466G>A | p.Val156Met | p.V156M | Q86X76 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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