![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NFKBIL1 |
Gene summary for NFKBIL1 |
![]() |
Gene information | Species | Human | Gene symbol | NFKBIL1 | Gene ID | 4795 |
Gene name | NFKB inhibitor like 1 | |
Gene Alias | IKBL | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A0A0A0MRT5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4795 | NFKBIL1 | P48T-E | Human | Esophagus | ESCC | 1.07e-21 | 3.90e-01 | 0.0959 |
4795 | NFKBIL1 | P49T-E | Human | Esophagus | ESCC | 2.48e-12 | 1.07e+00 | 0.1768 |
4795 | NFKBIL1 | P52T-E | Human | Esophagus | ESCC | 7.89e-25 | 6.51e-01 | 0.1555 |
4795 | NFKBIL1 | P54T-E | Human | Esophagus | ESCC | 3.77e-31 | 5.68e-01 | 0.0975 |
4795 | NFKBIL1 | P56T-E | Human | Esophagus | ESCC | 3.53e-08 | 1.09e+00 | 0.1613 |
4795 | NFKBIL1 | P57T-E | Human | Esophagus | ESCC | 5.03e-26 | 4.61e-01 | 0.0926 |
4795 | NFKBIL1 | P61T-E | Human | Esophagus | ESCC | 1.00e-16 | 3.97e-01 | 0.099 |
4795 | NFKBIL1 | P62T-E | Human | Esophagus | ESCC | 3.62e-47 | 8.16e-01 | 0.1302 |
4795 | NFKBIL1 | P65T-E | Human | Esophagus | ESCC | 1.16e-29 | 4.98e-01 | 0.0978 |
4795 | NFKBIL1 | P74T-E | Human | Esophagus | ESCC | 8.49e-35 | 7.62e-01 | 0.1479 |
4795 | NFKBIL1 | P75T-E | Human | Esophagus | ESCC | 3.49e-47 | 9.21e-01 | 0.1125 |
4795 | NFKBIL1 | P76T-E | Human | Esophagus | ESCC | 4.28e-31 | 7.32e-01 | 0.1207 |
4795 | NFKBIL1 | P79T-E | Human | Esophagus | ESCC | 3.63e-24 | 5.32e-01 | 0.1154 |
4795 | NFKBIL1 | P80T-E | Human | Esophagus | ESCC | 2.50e-49 | 1.29e+00 | 0.155 |
4795 | NFKBIL1 | P82T-E | Human | Esophagus | ESCC | 4.42e-24 | 1.03e+00 | 0.1072 |
4795 | NFKBIL1 | P83T-E | Human | Esophagus | ESCC | 5.42e-33 | 8.78e-01 | 0.1738 |
4795 | NFKBIL1 | P84T-E | Human | Esophagus | ESCC | 6.95e-09 | 3.32e-01 | 0.0933 |
4795 | NFKBIL1 | P89T-E | Human | Esophagus | ESCC | 9.06e-35 | 1.47e+00 | 0.1752 |
4795 | NFKBIL1 | P91T-E | Human | Esophagus | ESCC | 5.23e-16 | 1.18e+00 | 0.1828 |
4795 | NFKBIL1 | P107T-E | Human | Esophagus | ESCC | 3.27e-42 | 9.40e-01 | 0.171 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:00028325 | Esophagus | HGIN | negative regulation of response to biotic stimulus | 25/2587 | 108/18723 | 5.87e-03 | 4.77e-02 | 25 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
GO:003249619 | Esophagus | ESCC | response to lipopolysaccharide | 191/8552 | 343/18723 | 1.11e-04 | 7.73e-04 | 191 |
GO:000223719 | Esophagus | ESCC | response to molecule of bacterial origin | 194/8552 | 363/18723 | 1.64e-03 | 7.61e-03 | 194 |
GO:00434332 | Esophagus | ESCC | negative regulation of DNA-binding transcription factor activity | 103/8552 | 185/18723 | 3.86e-03 | 1.57e-02 | 103 |
GO:007122215 | Esophagus | ESCC | cellular response to lipopolysaccharide | 113/8552 | 209/18723 | 8.79e-03 | 3.10e-02 | 113 |
GO:00316633 | Esophagus | ESCC | lipopolysaccharide-mediated signaling pathway | 37/8552 | 60/18723 | 9.17e-03 | 3.19e-02 | 37 |
GO:007121617 | Esophagus | ESCC | cellular response to biotic stimulus | 131/8552 | 246/18723 | 9.85e-03 | 3.39e-02 | 131 |
GO:00320882 | Esophagus | ESCC | negative regulation of NF-kappaB transcription factor activity | 54/8552 | 93/18723 | 1.08e-02 | 3.67e-02 | 54 |
GO:00072494 | Liver | Cirrhotic | I-kappaB kinase/NF-kappaB signaling | 108/4634 | 281/18723 | 2.21e-07 | 5.64e-06 | 108 |
GO:00324966 | Liver | Cirrhotic | response to lipopolysaccharide | 111/4634 | 343/18723 | 8.15e-04 | 5.95e-03 | 111 |
GO:0002832 | Liver | Cirrhotic | negative regulation of response to biotic stimulus | 41/4634 | 108/18723 | 1.56e-03 | 1.01e-02 | 41 |
GO:00022376 | Liver | Cirrhotic | response to molecule of bacterial origin | 113/4634 | 363/18723 | 3.23e-03 | 1.81e-02 | 113 |
GO:00028311 | Liver | Cirrhotic | regulation of response to biotic stimulus | 101/4634 | 327/18723 | 6.58e-03 | 3.25e-02 | 101 |
GO:00022211 | Liver | HCC | pattern recognition receptor signaling pathway | 107/7958 | 172/18723 | 1.37e-07 | 2.58e-06 | 107 |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFKBIL1 | SNV | Missense_Mutation | novel | c.766N>C | p.Glu256Gln | p.E256Q | Q9UBC1 | protein_coding | tolerated(0.05) | probably_damaging(0.92) | TCGA-VS-A8QM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
NFKBIL1 | SNV | Missense_Mutation | c.434N>A | p.Gly145Glu | p.G145E | Q9UBC1 | protein_coding | tolerated(1) | benign(0.075) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
NFKBIL1 | SNV | Missense_Mutation | c.648G>T | p.Gln216His | p.Q216H | Q9UBC1 | protein_coding | tolerated(0.1) | benign(0.435) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
NFKBIL1 | SNV | Missense_Mutation | c.857N>G | p.Pro286Arg | p.P286R | Q9UBC1 | protein_coding | tolerated(0.5) | benign(0.197) | TCGA-F5-6863-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | etoposide | SD | |
NFKBIL1 | SNV | Missense_Mutation | novel | c.368N>A | p.Arg123His | p.R123H | Q9UBC1 | protein_coding | tolerated(0.45) | benign(0.203) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFKBIL1 | SNV | Missense_Mutation | novel | c.172N>T | p.Gly58Cys | p.G58C | Q9UBC1 | protein_coding | deleterious(0.03) | possibly_damaging(0.68) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFKBIL1 | SNV | Missense_Mutation | rs776864117 | c.653N>A | p.Arg218Gln | p.R218Q | Q9UBC1 | protein_coding | tolerated(0.38) | benign(0.005) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NFKBIL1 | SNV | Missense_Mutation | rs771750904 | c.610C>T | p.Arg204Cys | p.R204C | Q9UBC1 | protein_coding | tolerated(0.06) | benign(0.245) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFKBIL1 | SNV | Missense_Mutation | rs544896018 | c.367N>T | p.Arg123Cys | p.R123C | Q9UBC1 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFKBIL1 | SNV | Missense_Mutation | rs199596929 | c.772N>T | p.Arg258Cys | p.R258C | Q9UBC1 | protein_coding | tolerated(0.06) | benign(0.044) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4795 | NFKBIL1 | NA | IFN | 16362817 |
Page: 1 |