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Gene: NCOA5 |
Gene summary for NCOA5 |
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Gene information | Species | Human | Gene symbol | NCOA5 | Gene ID | 57727 |
Gene name | nuclear receptor coactivator 5 | |
Gene Alias | CIA | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9HCD5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57727 | NCOA5 | P76T-E | Human | Esophagus | ESCC | 3.05e-10 | 1.53e-01 | 0.1207 |
57727 | NCOA5 | P79T-E | Human | Esophagus | ESCC | 4.75e-14 | 3.31e-01 | 0.1154 |
57727 | NCOA5 | P80T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.19e-01 | 0.155 |
57727 | NCOA5 | P82T-E | Human | Esophagus | ESCC | 1.63e-05 | 2.86e-01 | 0.1072 |
57727 | NCOA5 | P83T-E | Human | Esophagus | ESCC | 1.71e-12 | 3.69e-01 | 0.1738 |
57727 | NCOA5 | P89T-E | Human | Esophagus | ESCC | 1.72e-03 | 4.06e-01 | 0.1752 |
57727 | NCOA5 | P91T-E | Human | Esophagus | ESCC | 9.42e-10 | 8.33e-01 | 0.1828 |
57727 | NCOA5 | P107T-E | Human | Esophagus | ESCC | 1.27e-08 | 2.41e-01 | 0.171 |
57727 | NCOA5 | P126T-E | Human | Esophagus | ESCC | 1.42e-03 | 3.05e-01 | 0.1125 |
57727 | NCOA5 | P127T-E | Human | Esophagus | ESCC | 5.63e-06 | 1.20e-01 | 0.0826 |
57727 | NCOA5 | P128T-E | Human | Esophagus | ESCC | 1.48e-21 | 7.00e-01 | 0.1241 |
57727 | NCOA5 | P130T-E | Human | Esophagus | ESCC | 4.25e-13 | 2.75e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:003286918 | Esophagus | ESCC | cellular response to insulin stimulus | 124/8552 | 203/18723 | 6.63e-06 | 6.75e-05 | 124 |
GO:003286818 | Esophagus | ESCC | response to insulin | 156/8552 | 264/18723 | 7.21e-06 | 7.20e-05 | 156 |
GO:007137516 | Esophagus | ESCC | cellular response to peptide hormone stimulus | 166/8552 | 290/18723 | 4.48e-05 | 3.55e-04 | 166 |
GO:00082869 | Esophagus | ESCC | insulin receptor signaling pathway | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCOA5 | SNV | Missense_Mutation | c.43N>A | p.Pro15Thr | p.P15T | Q9HCD5 | protein_coding | deleterious_low_confidence(0.02) | benign(0.04) | TCGA-A2-A0CW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
NCOA5 | SNV | Missense_Mutation | novel | c.576N>G | p.Phe192Leu | p.F192L | Q9HCD5 | protein_coding | tolerated(0.11) | benign(0.199) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
NCOA5 | SNV | Missense_Mutation | novel | c.642N>C | p.Glu214Asp | p.E214D | Q9HCD5 | protein_coding | deleterious(0.01) | probably_damaging(0.909) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
NCOA5 | SNV | Missense_Mutation | c.703N>C | p.Glu235Gln | p.E235Q | Q9HCD5 | protein_coding | tolerated(0.11) | probably_damaging(0.99) | TCGA-AR-A24U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
NCOA5 | SNV | Missense_Mutation | novel | c.446N>C | p.Arg149Thr | p.R149T | Q9HCD5 | protein_coding | deleterious(0.03) | possibly_damaging(0.586) | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NCOA5 | SNV | Missense_Mutation | rs758269352 | c.583N>A | p.Glu195Lys | p.E195K | Q9HCD5 | protein_coding | deleterious(0.01) | possibly_damaging(0.839) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NCOA5 | SNV | Missense_Mutation | rs370602943 | c.35G>A | p.Arg12Gln | p.R12Q | Q9HCD5 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.979) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
NCOA5 | SNV | Missense_Mutation | c.945G>C | p.Lys315Asn | p.K315N | Q9HCD5 | protein_coding | tolerated(0.09) | probably_damaging(0.976) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NCOA5 | SNV | Missense_Mutation | novel | c.428N>G | p.Ser143Cys | p.S143C | Q9HCD5 | protein_coding | deleterious(0.02) | benign(0.068) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NCOA5 | SNV | Missense_Mutation | c.556N>A | p.Glu186Lys | p.E186K | Q9HCD5 | protein_coding | deleterious(0.01) | benign(0.121) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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