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Gene: NBPF14 |
Gene summary for NBPF14 |
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Gene information | Species | Human | Gene symbol | NBPF14 | Gene ID | 25832 |
Gene name | NBPF member 14 | |
Gene Alias | DJ328E19.C1.1 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WZJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25832 | NBPF14 | P49T-E | Human | Esophagus | ESCC | 2.80e-04 | 3.18e-01 | 0.1768 |
25832 | NBPF14 | P52T-E | Human | Esophagus | ESCC | 2.23e-08 | 1.12e-01 | 0.1555 |
25832 | NBPF14 | P54T-E | Human | Esophagus | ESCC | 7.70e-04 | 7.19e-02 | 0.0975 |
25832 | NBPF14 | P56T-E | Human | Esophagus | ESCC | 1.03e-10 | 1.44e+00 | 0.1613 |
25832 | NBPF14 | P57T-E | Human | Esophagus | ESCC | 4.37e-17 | 3.56e-01 | 0.0926 |
25832 | NBPF14 | P61T-E | Human | Esophagus | ESCC | 8.33e-08 | 9.78e-02 | 0.099 |
25832 | NBPF14 | P62T-E | Human | Esophagus | ESCC | 9.12e-11 | 1.84e-01 | 0.1302 |
25832 | NBPF14 | P65T-E | Human | Esophagus | ESCC | 5.48e-17 | 3.65e-01 | 0.0978 |
25832 | NBPF14 | P74T-E | Human | Esophagus | ESCC | 6.88e-17 | 5.34e-01 | 0.1479 |
25832 | NBPF14 | P75T-E | Human | Esophagus | ESCC | 5.64e-98 | 1.72e+00 | 0.1125 |
25832 | NBPF14 | P76T-E | Human | Esophagus | ESCC | 1.09e-57 | 9.12e-01 | 0.1207 |
25832 | NBPF14 | P79T-E | Human | Esophagus | ESCC | 3.08e-40 | 7.04e-01 | 0.1154 |
25832 | NBPF14 | P80T-E | Human | Esophagus | ESCC | 1.69e-33 | 8.05e-01 | 0.155 |
25832 | NBPF14 | P82T-E | Human | Esophagus | ESCC | 1.52e-22 | 1.17e+00 | 0.1072 |
25832 | NBPF14 | P83T-E | Human | Esophagus | ESCC | 7.92e-09 | 2.48e-01 | 0.1738 |
25832 | NBPF14 | P89T-E | Human | Esophagus | ESCC | 1.64e-18 | 9.12e-01 | 0.1752 |
25832 | NBPF14 | P107T-E | Human | Esophagus | ESCC | 1.43e-50 | 1.14e+00 | 0.171 |
25832 | NBPF14 | P126T-E | Human | Esophagus | ESCC | 5.90e-17 | 1.22e+00 | 0.1125 |
25832 | NBPF14 | P127T-E | Human | Esophagus | ESCC | 9.19e-11 | 2.11e-01 | 0.0826 |
25832 | NBPF14 | P128T-E | Human | Esophagus | ESCC | 1.84e-16 | 5.53e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF14 | SNV | Missense_Mutation | novel | c.4984G>A | p.Asp1662Asn | p.D1662N | protein_coding | deleterious(0.02) | possibly_damaging(0.728) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.3493N>T | p.Ile1165Phe | p.I1165F | protein_coding | tolerated(0.07) | benign(0.249) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.5N>C | p.Val2Ala | p.V2A | protein_coding | tolerated(0.06) | benign(0.285) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.8605G>A | p.Asp2869Asn | p.D2869N | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
NBPF14 | SNV | Missense_Mutation | novel | c.1081N>A | p.Glu361Lys | p.E361K | protein_coding | deleterious(0.02) | possibly_damaging(0.486) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.1827N>T | p.Lys609Asn | p.K609N | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-EW-A1OX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.193G>C | p.Asp65His | p.D65H | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | insertion | Frame_Shift_Ins | novel | c.8645_8646insT | p.Arg2882SerfsTer39 | p.R2882Sfs*39 | protein_coding | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |||
NBPF14 | SNV | Missense_Mutation | novel | c.251N>G | p.Glu84Gly | p.E84G | protein_coding | deleterious(0) | possibly_damaging(0.479) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.1044N>G | p.Phe348Leu | p.F348L | protein_coding | tolerated(0.22) | benign(0.294) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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