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Gene: N4BP2L1 |
Gene summary for N4BP2L1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | N4BP2L1 | Gene ID | 90634 |
Gene name | NEDD4 binding protein 2 like 1 | |
Gene Alias | CG018 | |
Cytomap | 13q13.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A024RDV1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90634 | N4BP2L1 | P128T-E | Human | Esophagus | ESCC | 1.46e-20 | 5.49e-01 | 0.1241 |
90634 | N4BP2L1 | P130T-E | Human | Esophagus | ESCC | 2.00e-08 | 2.22e-01 | 0.1676 |
90634 | N4BP2L1 | HTA12-26-1 | Human | Pancreas | PDAC | 5.55e-05 | 3.94e-01 | 0.3728 |
90634 | N4BP2L1 | HTA12-29-1 | Human | Pancreas | PDAC | 3.59e-21 | 5.63e-01 | 0.3722 |
90634 | N4BP2L1 | HTA12-32-1 | Human | Pancreas | PDAC | 1.23e-02 | 7.44e-01 | 0.3624 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
N4BP2L1 | SNV | Missense_Mutation | c.85N>A | p.Pro29Thr | p.P29T | Q5TBK1 | protein_coding | tolerated(0.36) | possibly_damaging(0.637) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
N4BP2L1 | SNV | Missense_Mutation | rs754642145 | c.443G>A | p.Arg148His | p.R148H | Q5TBK1 | protein_coding | tolerated(0.52) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
N4BP2L1 | SNV | Missense_Mutation | c.377N>C | p.Met126Thr | p.M126T | Q5TBK1 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-DC-6158-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
N4BP2L1 | SNV | Missense_Mutation | c.476N>A | p.Arg159Lys | p.R159K | Q5TBK1 | protein_coding | tolerated(0.06) | possibly_damaging(0.545) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
N4BP2L1 | SNV | Missense_Mutation | novel | c.535G>A | p.Asp179Asn | p.D179N | Q5TBK1 | protein_coding | tolerated(0.51) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
N4BP2L1 | deletion | Frame_Shift_Del | c.483_486delNNNN | p.Ile161MetfsTer11 | p.I161Mfs*11 | Q5TBK1 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
N4BP2L1 | SNV | Missense_Mutation | novel | c.220A>G | p.Thr74Ala | p.T74A | Q5TBK1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
N4BP2L1 | SNV | Missense_Mutation | novel | c.251N>T | p.Ala84Val | p.A84V | Q5TBK1 | protein_coding | tolerated(0.37) | benign(0.023) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
N4BP2L1 | SNV | Missense_Mutation | rs766580917 | c.512N>A | p.Arg171Gln | p.R171Q | Q5TBK1 | protein_coding | tolerated(0.32) | possibly_damaging(0.763) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
N4BP2L1 | SNV | Missense_Mutation | c.308C>G | p.Ala103Gly | p.A103G | Q5TBK1 | protein_coding | deleterious(0.04) | benign(0.279) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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