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Gene: MYADM |
Gene summary for MYADM |
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Gene information | Species | Human | Gene symbol | MYADM | Gene ID | 91663 |
Gene name | myeloid associated differentiation marker | |
Gene Alias | SB135 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R4N0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91663 | MYADM | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.07e-27 | 7.36e-01 | 0.3859 |
91663 | MYADM | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.36e-03 | 2.84e-01 | 0.2585 |
91663 | MYADM | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.39e-03 | 2.04e-01 | 0.3005 |
91663 | MYADM | AEH-subject2 | Human | Endometrium | AEH | 6.41e-03 | -3.33e-01 | -0.2525 |
91663 | MYADM | AEH-subject5 | Human | Endometrium | AEH | 6.53e-16 | -5.51e-01 | -0.2953 |
91663 | MYADM | EEC-subject1 | Human | Endometrium | EEC | 6.64e-05 | -3.76e-01 | -0.2682 |
91663 | MYADM | EEC-subject2 | Human | Endometrium | EEC | 2.36e-11 | -4.74e-01 | -0.2607 |
91663 | MYADM | EEC-subject3 | Human | Endometrium | EEC | 3.91e-17 | -4.24e-01 | -0.2525 |
91663 | MYADM | EEC-subject4 | Human | Endometrium | EEC | 2.17e-07 | -4.35e-01 | -0.2571 |
91663 | MYADM | EEC-subject5 | Human | Endometrium | EEC | 6.25e-05 | -3.95e-01 | -0.249 |
91663 | MYADM | GSM5276935 | Human | Endometrium | EEC | 4.97e-12 | -5.33e-01 | -0.123 |
91663 | MYADM | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.18e-16 | -2.35e-02 | -0.1869 |
91663 | MYADM | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.98e-12 | -3.22e-01 | -0.1875 |
91663 | MYADM | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.78e-20 | -3.02e-01 | -0.1883 |
91663 | MYADM | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.96e-07 | -2.16e-01 | -0.1934 |
91663 | MYADM | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.56e-22 | -4.71e-02 | -0.1917 |
91663 | MYADM | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.63e-24 | -7.74e-02 | -0.1916 |
91663 | MYADM | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.66e-04 | -3.94e-01 | -0.1269 |
91663 | MYADM | LZE4T | Human | Esophagus | ESCC | 6.40e-18 | 9.49e-01 | 0.0811 |
91663 | MYADM | LZE5T | Human | Esophagus | ESCC | 1.24e-02 | 6.09e-03 | 0.0514 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:19000249 | Cervix | CC | regulation of substrate adhesion-dependent cell spreading | 23/2311 | 57/18723 | 8.94e-08 | 5.04e-06 | 23 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00107699 | Cervix | CC | regulation of cell morphogenesis involved in differentiation | 31/2311 | 96/18723 | 2.43e-07 | 1.05e-05 | 31 |
GO:00344469 | Cervix | CC | substrate adhesion-dependent cell spreading | 32/2311 | 108/18723 | 1.36e-06 | 4.55e-05 | 32 |
GO:00224084 | Cervix | CC | negative regulation of cell-cell adhesion | 48/2311 | 196/18723 | 1.99e-06 | 6.18e-05 | 48 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYADM | SNV | Missense_Mutation | c.884N>T | p.Ala295Val | p.A295V | Q96S97 | protein_coding | tolerated(0.08) | possibly_damaging(0.589) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MYADM | insertion | Frame_Shift_Ins | novel | c.148_149insACCACACCCGG | p.Ala50AspfsTer33 | p.A50Dfs*33 | Q96S97 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MYADM | SNV | Missense_Mutation | c.7G>A | p.Val3Met | p.V3M | Q96S97 | protein_coding | tolerated_low_confidence(0.17) | benign(0.295) | TCGA-C5-A1MQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
MYADM | SNV | Missense_Mutation | novel | c.415G>A | p.Ala139Thr | p.A139T | Q96S97 | protein_coding | tolerated(0.33) | possibly_damaging(0.68) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MYADM | SNV | Missense_Mutation | rs775841521 | c.398N>T | p.Ser133Leu | p.S133L | Q96S97 | protein_coding | tolerated(0.63) | benign(0.092) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MYADM | SNV | Missense_Mutation | novel | c.136N>G | p.Ser46Ala | p.S46A | Q96S97 | protein_coding | tolerated(0.13) | probably_damaging(0.989) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYADM | SNV | Missense_Mutation | c.410N>T | p.Ala137Val | p.A137V | Q96S97 | protein_coding | tolerated(0.1) | possibly_damaging(0.657) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MYADM | SNV | Missense_Mutation | rs776582147 | c.899N>T | p.Thr300Met | p.T300M | Q96S97 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYADM | SNV | Missense_Mutation | c.584N>G | p.Asn195Ser | p.N195S | Q96S97 | protein_coding | tolerated(0.63) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYADM | SNV | Missense_Mutation | c.805N>A | p.Gly269Ser | p.G269S | Q96S97 | protein_coding | deleterious(0.01) | benign(0.164) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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