Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MUC3A_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MUC3A_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MUC3A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/MUC3A_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC3A | SNV | Missense_Mutation | novel | c.9826G>A | p.Glu3276Lys | p.E3276K | Q02505 | protein_coding | tolerated_low_confidence(0.11) | benign(0.389) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MUC3A | SNV | Missense_Mutation | novel | c.8342N>T | p.Ser2781Phe | p.S2781F | Q02505 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-A8-A08J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MUC3A | SNV | Missense_Mutation | novel | c.8003N>G | p.Thr2668Arg | p.T2668R | Q02505 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.857) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
MUC3A | SNV | Missense_Mutation | novel | c.7985C>T | p.Ser2662Phe | p.S2662F | Q02505 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.721) | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MUC3A | SNV | Missense_Mutation | novel | c.7778N>T | p.Ser2593Phe | p.S2593F | Q02505 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.1115N>T | p.Ser372Phe | p.S372F | Q02505 | protein_coding | deleterious_low_confidence(0.01) | unknown(0) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.4718N>T | p.Thr1573Ile | p.T1573I | Q02505 | protein_coding | tolerated_low_confidence(0.12) | unknown(0) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.5768G>T | p.Arg1923Ile | p.R1923I | Q02505 | protein_coding | tolerated_low_confidence(0.26) | unknown(0) | TCGA-BH-A0B3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
MUC3A | SNV | Missense_Mutation | novel | c.8045N>T | p.Trp2682Leu | p.W2682L | Q02505 | protein_coding | tolerated_low_confidence(0.88) | benign(0) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
MUC3A | SNV | Missense_Mutation | rs753787832 | c.7940C>T | p.Ser2647Leu | p.S2647L | Q02505 | protein_coding | deleterious_low_confidence(0.01) | benign(0.015) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |