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Gene: MTRNR2L12 |
Gene summary for MTRNR2L12 |
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Gene information | Species | Human | Gene symbol | MTRNR2L12 | Gene ID | 100463498 |
Gene name | MT-RNR2 like 12 | |
Gene Alias | HN12 | |
Cytomap | 3q11.2 | |
Gene Type | pseudo | GO ID | GO:0006915 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100463498 | MTRNR2L12 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.21e-23 | 1.00e+00 | -0.0811 |
100463498 | MTRNR2L12 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.62e-11 | 9.71e-01 | -0.1088 |
100463498 | MTRNR2L12 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.05e-71 | 1.75e+00 | -0.1954 |
100463498 | MTRNR2L12 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.21e-12 | 1.60e+00 | -0.2602 |
100463498 | MTRNR2L12 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.88e-07 | 1.33e+00 | -0.2196 |
100463498 | MTRNR2L12 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.89e-12 | 8.64e-01 | -0.1207 |
100463498 | MTRNR2L12 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.87e-18 | 9.99e-01 | -0.1526 |
100463498 | MTRNR2L12 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-28 | 7.63e-01 | -0.1464 |
100463498 | MTRNR2L12 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.52e-14 | 4.91e-01 | -0.1001 |
100463498 | MTRNR2L12 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.30e-09 | 6.69e-01 | -0.059 |
100463498 | MTRNR2L12 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.33e-28 | 1.87e+00 | -0.1706 |
100463498 | MTRNR2L12 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.56e-22 | 1.60e+00 | -0.2061 |
100463498 | MTRNR2L12 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.60e-18 | 1.89e+00 | -0.1462 |
100463498 | MTRNR2L12 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.39e-09 | 7.79e-01 | -0.0842 |
100463498 | MTRNR2L12 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.08e-02 | 6.13e-01 | 0.0446 |
100463498 | MTRNR2L12 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.50e-15 | 1.47e+00 | 0.0131 |
100463498 | MTRNR2L12 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.59e-03 | -5.12e-03 | 0.0338 |
100463498 | MTRNR2L12 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.57e-12 | 7.11e-01 | 0.0588 |
100463498 | MTRNR2L12 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.01e-04 | 1.93e-01 | 0.294 |
100463498 | MTRNR2L12 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.06e-82 | 6.47e+00 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097194 | Liver | HCC | execution phase of apoptosis | 48/7958 | 85/18723 | 6.47e-03 | 2.63e-02 | 48 |
GO:1900117 | Liver | HCC | regulation of execution phase of apoptosis | 19/7958 | 29/18723 | 1.05e-02 | 3.89e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTRNR2L12 | SNV | Missense_Mutation | c.11N>A | p.Arg4Gln | p.R4Q | P0DMP1 | protein_coding | tolerated_low_confidence(0.27) | benign(0.412) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTRNR2L12 | SNV | Missense_Mutation | c.31C>A | p.Leu11Ile | p.L11I | P0DMP1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.578) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
MTRNR2L12 | SNV | Missense_Mutation | c.11G>A | p.Arg4Gln | p.R4Q | P0DMP1 | protein_coding | tolerated_low_confidence(0.27) | benign(0.412) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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