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Gene: MTFP1 |
Gene summary for MTFP1 |
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Gene information | Species | Human | Gene symbol | MTFP1 | Gene ID | 51537 |
Gene name | mitochondrial fission process 1 | |
Gene Alias | HSPC242 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | Q9UDX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51537 | MTFP1 | P74T-E | Human | Esophagus | ESCC | 1.44e-44 | 1.25e+00 | 0.1479 |
51537 | MTFP1 | P75T-E | Human | Esophagus | ESCC | 1.68e-20 | 4.54e-01 | 0.1125 |
51537 | MTFP1 | P76T-E | Human | Esophagus | ESCC | 1.12e-22 | 6.40e-01 | 0.1207 |
51537 | MTFP1 | P79T-E | Human | Esophagus | ESCC | 7.71e-19 | 4.15e-01 | 0.1154 |
51537 | MTFP1 | P80T-E | Human | Esophagus | ESCC | 6.60e-23 | 8.32e-01 | 0.155 |
51537 | MTFP1 | P82T-E | Human | Esophagus | ESCC | 6.88e-11 | 6.11e-01 | 0.1072 |
51537 | MTFP1 | P83T-E | Human | Esophagus | ESCC | 2.12e-67 | 2.22e+00 | 0.1738 |
51537 | MTFP1 | P89T-E | Human | Esophagus | ESCC | 3.61e-19 | 1.15e+00 | 0.1752 |
51537 | MTFP1 | P91T-E | Human | Esophagus | ESCC | 1.36e-19 | 1.71e+00 | 0.1828 |
51537 | MTFP1 | P104T-E | Human | Esophagus | ESCC | 3.25e-05 | 4.43e-01 | 0.0931 |
51537 | MTFP1 | P107T-E | Human | Esophagus | ESCC | 1.59e-38 | 9.96e-01 | 0.171 |
51537 | MTFP1 | P126T-E | Human | Esophagus | ESCC | 1.17e-03 | 5.23e-01 | 0.1125 |
51537 | MTFP1 | P128T-E | Human | Esophagus | ESCC | 2.45e-31 | 9.63e-01 | 0.1241 |
51537 | MTFP1 | P130T-E | Human | Esophagus | ESCC | 9.70e-40 | 8.81e-01 | 0.1676 |
51537 | MTFP1 | HCC1_Meng | Human | Liver | HCC | 1.21e-38 | 1.26e-01 | 0.0246 |
51537 | MTFP1 | HCC2 | Human | Liver | HCC | 4.08e-04 | 2.09e+00 | 0.5341 |
51537 | MTFP1 | S014 | Human | Liver | HCC | 1.61e-08 | 3.73e-01 | 0.2254 |
51537 | MTFP1 | S015 | Human | Liver | HCC | 1.70e-12 | 6.07e-01 | 0.2375 |
51537 | MTFP1 | S016 | Human | Liver | HCC | 6.38e-10 | 4.26e-01 | 0.2243 |
51537 | MTFP1 | S027 | Human | Liver | HCC | 7.30e-07 | 6.12e-01 | 0.2446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002662 | Esophagus | ESCC | mitochondrial fission | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
GO:0000266 | Liver | HCC | mitochondrial fission | 28/7958 | 42/18723 | 1.35e-03 | 7.26e-03 | 28 |
GO:00148231 | Liver | HCC | response to activity | 45/7958 | 76/18723 | 2.42e-03 | 1.18e-02 | 45 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
GO:00148233 | Oral cavity | OSCC | response to activity | 41/7305 | 76/18723 | 5.78e-03 | 2.22e-02 | 41 |
GO:00002661 | Oral cavity | OSCC | mitochondrial fission | 24/7305 | 42/18723 | 1.30e-02 | 4.34e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTFP1 | SNV | Missense_Mutation | c.32G>A | p.Arg11His | p.R11H | Q9UDX5 | protein_coding | tolerated(0.25) | benign(0.179) | TCGA-E9-A249-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
MTFP1 | SNV | Missense_Mutation | c.163N>A | p.Asp55Asn | p.D55N | Q9UDX5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
MTFP1 | SNV | Missense_Mutation | rs112718421 | c.382G>A | p.Ala128Thr | p.A128T | Q9UDX5 | protein_coding | tolerated(0.1) | benign(0.103) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MTFP1 | SNV | Missense_Mutation | c.25N>A | p.Ala9Thr | p.A9T | Q9UDX5 | protein_coding | tolerated(0.5) | benign(0) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MTFP1 | SNV | Missense_Mutation | rs775396821 | c.304N>T | p.Arg102Cys | p.R102C | Q9UDX5 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD |
MTFP1 | SNV | Missense_Mutation | rs369745248 | c.461G>A | p.Arg154His | p.R154H | Q9UDX5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTFP1 | insertion | Frame_Shift_Ins | novel | c.355_356insA | p.Leu119HisfsTer24 | p.L119Hfs*24 | Q9UDX5 | protein_coding | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
MTFP1 | SNV | Missense_Mutation | novel | c.265G>T | p.Ala89Ser | p.A89S | Q9UDX5 | protein_coding | tolerated(0.74) | benign(0.006) | TCGA-NI-A8LF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MTFP1 | SNV | Missense_Mutation | c.437N>T | p.Asp146Val | p.D146V | Q9UDX5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTFP1 | SNV | Missense_Mutation | novel | c.275N>A | p.Ser92Tyr | p.S92Y | Q9UDX5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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