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Gene: MRS2 |
Gene summary for MRS2 |
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Gene information | Species | Human | Gene symbol | MRS2 | Gene ID | 57380 |
Gene name | magnesium transporter MRS2 | |
Gene Alias | HPT | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9HD23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57380 | MRS2 | P52T-E | Human | Esophagus | ESCC | 7.72e-31 | 6.69e-01 | 0.1555 |
57380 | MRS2 | P54T-E | Human | Esophagus | ESCC | 3.84e-07 | 2.54e-01 | 0.0975 |
57380 | MRS2 | P56T-E | Human | Esophagus | ESCC | 1.25e-12 | 1.11e+00 | 0.1613 |
57380 | MRS2 | P57T-E | Human | Esophagus | ESCC | 6.95e-12 | 2.02e-01 | 0.0926 |
57380 | MRS2 | P61T-E | Human | Esophagus | ESCC | 1.12e-17 | 4.08e-01 | 0.099 |
57380 | MRS2 | P62T-E | Human | Esophagus | ESCC | 5.47e-39 | 6.85e-01 | 0.1302 |
57380 | MRS2 | P65T-E | Human | Esophagus | ESCC | 5.50e-20 | 4.38e-01 | 0.0978 |
57380 | MRS2 | P74T-E | Human | Esophagus | ESCC | 1.84e-18 | 5.62e-01 | 0.1479 |
57380 | MRS2 | P75T-E | Human | Esophagus | ESCC | 1.25e-28 | 5.68e-01 | 0.1125 |
57380 | MRS2 | P76T-E | Human | Esophagus | ESCC | 1.42e-18 | 3.25e-01 | 0.1207 |
57380 | MRS2 | P79T-E | Human | Esophagus | ESCC | 2.13e-30 | 5.94e-01 | 0.1154 |
57380 | MRS2 | P80T-E | Human | Esophagus | ESCC | 4.25e-51 | 1.37e+00 | 0.155 |
57380 | MRS2 | P82T-E | Human | Esophagus | ESCC | 1.41e-07 | 4.56e-01 | 0.1072 |
57380 | MRS2 | P83T-E | Human | Esophagus | ESCC | 8.11e-24 | 6.36e-01 | 0.1738 |
57380 | MRS2 | P89T-E | Human | Esophagus | ESCC | 9.48e-14 | 8.78e-01 | 0.1752 |
57380 | MRS2 | P91T-E | Human | Esophagus | ESCC | 7.62e-10 | 1.15e+00 | 0.1828 |
57380 | MRS2 | P107T-E | Human | Esophagus | ESCC | 1.20e-32 | 7.74e-01 | 0.171 |
57380 | MRS2 | P126T-E | Human | Esophagus | ESCC | 1.34e-04 | 4.35e-01 | 0.1125 |
57380 | MRS2 | P127T-E | Human | Esophagus | ESCC | 2.44e-14 | 2.94e-01 | 0.0826 |
57380 | MRS2 | P128T-E | Human | Esophagus | ESCC | 7.90e-33 | 9.87e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:199054212 | Liver | HCC | mitochondrial transmembrane transport | 78/7958 | 102/18723 | 2.73e-12 | 1.26e-10 | 78 |
GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
GO:199054218 | Oral cavity | OSCC | mitochondrial transmembrane transport | 56/7305 | 102/18723 | 8.06e-04 | 4.32e-03 | 56 |
GO:000683919 | Oral cavity | LP | mitochondrial transport | 119/4623 | 254/18723 | 1.06e-14 | 1.33e-12 | 119 |
GO:199054219 | Oral cavity | LP | mitochondrial transmembrane transport | 37/4623 | 102/18723 | 5.93e-03 | 3.53e-02 | 37 |
GO:000683927 | Skin | cSCC | mitochondrial transport | 124/4864 | 254/18723 | 3.54e-15 | 2.81e-13 | 124 |
GO:199054224 | Skin | cSCC | mitochondrial transmembrane transport | 43/4864 | 102/18723 | 2.68e-04 | 2.16e-03 | 43 |
GO:000683928 | Thyroid | PTC | mitochondrial transport | 150/5968 | 254/18723 | 2.76e-19 | 3.34e-17 | 150 |
GO:199054225 | Thyroid | PTC | mitochondrial transmembrane transport | 57/5968 | 102/18723 | 4.49e-07 | 7.38e-06 | 57 |
GO:000683929 | Thyroid | ATC | mitochondrial transport | 151/6293 | 254/18723 | 2.07e-17 | 2.14e-15 | 151 |
GO:199054226 | Thyroid | ATC | mitochondrial transmembrane transport | 57/6293 | 102/18723 | 3.05e-06 | 3.49e-05 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRS2 | SNV | Missense_Mutation | novel | c.1052N>G | p.Ser351Cys | p.S351C | Q9HD23 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
MRS2 | SNV | Missense_Mutation | c.808G>C | p.Glu270Gln | p.E270Q | Q9HD23 | protein_coding | deleterious(0.03) | possibly_damaging(0.897) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRS2 | SNV | Missense_Mutation | c.1023N>C | p.Leu341Phe | p.L341F | Q9HD23 | protein_coding | tolerated(0.21) | probably_damaging(0.99) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MRS2 | insertion | Frame_Shift_Ins | novel | c.912_913insGCAG | p.Leu305AlafsTer4 | p.L305Afs*4 | Q9HD23 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
MRS2 | insertion | Nonsense_Mutation | novel | c.913_914insATCGTATCTAATTCAATGTAATTCTATGAGTATGCATAC | p.Arg304_Leu305insTyrArgIleTerPheAsnValIleLeuTerValCysIle | p.R304_L305insYRI*FNVIL*VCI | Q9HD23 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
MRS2 | SNV | Missense_Mutation | c.1251N>C | p.Lys417Asn | p.K417N | Q9HD23 | protein_coding | deleterious_low_confidence(0) | benign(0.046) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MRS2 | SNV | Missense_Mutation | rs765832035 | c.1124G>T | p.Arg375Ile | p.R375I | Q9HD23 | protein_coding | tolerated(0.23) | benign(0.175) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MRS2 | SNV | Missense_Mutation | rs765832035 | c.1124N>T | p.Arg375Ile | p.R375I | Q9HD23 | protein_coding | tolerated(0.23) | benign(0.175) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MRS2 | deletion | Frame_Shift_Del | c.1246delN | p.Lys417ArgfsTer11 | p.K417Rfs*11 | Q9HD23 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MRS2 | deletion | Frame_Shift_Del | c.1246delN | p.Lys417ArgfsTer11 | p.K417Rfs*11 | Q9HD23 | protein_coding | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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