![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MRPL47 |
Gene summary for MRPL47 |
![]() |
Gene information | Species | Human | Gene symbol | MRPL47 | Gene ID | 57129 |
Gene name | mitochondrial ribosomal protein L47 | |
Gene Alias | CGI-204 | |
Cytomap | 3q26.33 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9HD33 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57129 | MRPL47 | P10T-E | Human | Esophagus | ESCC | 4.17e-53 | 1.07e+00 | 0.116 |
57129 | MRPL47 | P11T-E | Human | Esophagus | ESCC | 3.13e-23 | 1.14e+00 | 0.1426 |
57129 | MRPL47 | P12T-E | Human | Esophagus | ESCC | 1.61e-72 | 1.53e+00 | 0.1122 |
57129 | MRPL47 | P15T-E | Human | Esophagus | ESCC | 4.99e-66 | 1.50e+00 | 0.1149 |
57129 | MRPL47 | P16T-E | Human | Esophagus | ESCC | 1.99e-43 | 9.96e-01 | 0.1153 |
57129 | MRPL47 | P17T-E | Human | Esophagus | ESCC | 2.12e-14 | 8.09e-01 | 0.1278 |
57129 | MRPL47 | P19T-E | Human | Esophagus | ESCC | 7.93e-10 | 1.35e+00 | 0.1662 |
57129 | MRPL47 | P20T-E | Human | Esophagus | ESCC | 3.50e-43 | 1.01e+00 | 0.1124 |
57129 | MRPL47 | P21T-E | Human | Esophagus | ESCC | 3.01e-60 | 1.57e+00 | 0.1617 |
57129 | MRPL47 | P22T-E | Human | Esophagus | ESCC | 4.69e-47 | 1.17e+00 | 0.1236 |
57129 | MRPL47 | P23T-E | Human | Esophagus | ESCC | 6.24e-57 | 1.63e+00 | 0.108 |
57129 | MRPL47 | P24T-E | Human | Esophagus | ESCC | 1.25e-42 | 1.30e+00 | 0.1287 |
57129 | MRPL47 | P26T-E | Human | Esophagus | ESCC | 7.59e-119 | 2.71e+00 | 0.1276 |
57129 | MRPL47 | P27T-E | Human | Esophagus | ESCC | 5.49e-75 | 1.95e+00 | 0.1055 |
57129 | MRPL47 | P28T-E | Human | Esophagus | ESCC | 5.26e-81 | 1.78e+00 | 0.1149 |
57129 | MRPL47 | P30T-E | Human | Esophagus | ESCC | 9.91e-45 | 1.65e+00 | 0.137 |
57129 | MRPL47 | P31T-E | Human | Esophagus | ESCC | 6.20e-54 | 1.15e+00 | 0.1251 |
57129 | MRPL47 | P32T-E | Human | Esophagus | ESCC | 1.12e-86 | 2.37e+00 | 0.1666 |
57129 | MRPL47 | P36T-E | Human | Esophagus | ESCC | 2.49e-31 | 1.01e+00 | 0.1187 |
57129 | MRPL47 | P37T-E | Human | Esophagus | ESCC | 3.77e-39 | 9.65e-01 | 0.1371 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00325432 | Breast | IDC | mitochondrial translation | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:003254311 | Breast | DCIS | mitochondrial translation | 13/1390 | 76/18723 | 3.70e-03 | 2.99e-02 | 13 |
GO:00325435 | Esophagus | HGIN | mitochondrial translation | 23/2587 | 76/18723 | 1.61e-04 | 3.16e-03 | 23 |
GO:01400534 | Esophagus | HGIN | mitochondrial gene expression | 27/2587 | 108/18723 | 1.34e-03 | 1.57e-02 | 27 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:003254313 | Oral cavity | LP | mitochondrial translation | 43/4623 | 76/18723 | 2.85e-09 | 1.26e-07 | 43 |
GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
GO:01400536 | Thyroid | PTC | mitochondrial gene expression | 51/5968 | 108/18723 | 6.04e-04 | 3.83e-03 | 51 |
GO:00325437 | Thyroid | PTC | mitochondrial translation | 38/5968 | 76/18723 | 7.52e-04 | 4.67e-03 | 38 |
GO:014005314 | Thyroid | ATC | mitochondrial gene expression | 51/6293 | 108/18723 | 2.26e-03 | 1.06e-02 | 51 |
GO:003254315 | Thyroid | ATC | mitochondrial translation | 38/6293 | 76/18723 | 2.26e-03 | 1.06e-02 | 38 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL47 | SNV | Missense_Mutation | rs762120814 | c.700N>A | p.Leu234Ile | p.L234I | Q9HD33 | protein_coding | tolerated(0.09) | possibly_damaging(0.497) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL47 | SNV | Missense_Mutation | c.273N>C | p.Arg91Ser | p.R91S | Q9HD33 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
MRPL47 | SNV | Missense_Mutation | novel | c.578N>C | p.Arg193Thr | p.R193T | Q9HD33 | protein_coding | deleterious(0.01) | benign(0.357) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL47 | SNV | Missense_Mutation | rs762120814 | c.700N>A | p.Leu234Ile | p.L234I | Q9HD33 | protein_coding | tolerated(0.09) | possibly_damaging(0.497) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRPL47 | SNV | Missense_Mutation | c.198A>C | p.Glu66Asp | p.E66D | Q9HD33 | protein_coding | tolerated(0.1) | benign(0.2) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MRPL47 | SNV | Missense_Mutation | c.5N>A | p.Ala2Asp | p.A2D | Q9HD33 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.927) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
MRPL47 | SNV | Missense_Mutation | rs762120814 | c.700N>A | p.Leu234Ile | p.L234I | Q9HD33 | protein_coding | tolerated(0.09) | possibly_damaging(0.497) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MRPL47 | SNV | Missense_Mutation | rs773754223 | c.647N>A | p.Arg216Gln | p.R216Q | Q9HD33 | protein_coding | tolerated(0.36) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MRPL47 | SNV | Missense_Mutation | novel | c.575A>G | p.Lys192Arg | p.K192R | Q9HD33 | protein_coding | tolerated(0.27) | benign(0.036) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MRPL47 | SNV | Missense_Mutation | novel | c.602N>T | p.Ala201Val | p.A201V | Q9HD33 | protein_coding | tolerated(0.46) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |