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Gene: MIEF1 |
Gene summary for MIEF1 |
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Gene information | Species | Human | Gene symbol | MIEF1 | Gene ID | 54471 |
Gene name | mitochondrial elongation factor 1 | |
Gene Alias | AltMIEF1 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | B0QY95 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54471 | MIEF1 | P49T-E | Human | Esophagus | ESCC | 5.76e-08 | 5.73e-01 | 0.1768 |
54471 | MIEF1 | P52T-E | Human | Esophagus | ESCC | 1.99e-13 | 2.88e-01 | 0.1555 |
54471 | MIEF1 | P54T-E | Human | Esophagus | ESCC | 1.58e-13 | 1.55e-01 | 0.0975 |
54471 | MIEF1 | P56T-E | Human | Esophagus | ESCC | 7.95e-12 | 5.37e-01 | 0.1613 |
54471 | MIEF1 | P57T-E | Human | Esophagus | ESCC | 9.30e-06 | 4.47e-02 | 0.0926 |
54471 | MIEF1 | P61T-E | Human | Esophagus | ESCC | 1.07e-17 | 3.56e-01 | 0.099 |
54471 | MIEF1 | P62T-E | Human | Esophagus | ESCC | 2.34e-19 | 4.71e-01 | 0.1302 |
54471 | MIEF1 | P65T-E | Human | Esophagus | ESCC | 3.60e-16 | 1.26e-01 | 0.0978 |
54471 | MIEF1 | P74T-E | Human | Esophagus | ESCC | 5.32e-14 | 2.83e-01 | 0.1479 |
54471 | MIEF1 | P75T-E | Human | Esophagus | ESCC | 2.80e-07 | 8.81e-02 | 0.1125 |
54471 | MIEF1 | P76T-E | Human | Esophagus | ESCC | 1.12e-17 | 1.23e-01 | 0.1207 |
54471 | MIEF1 | P79T-E | Human | Esophagus | ESCC | 2.57e-11 | 1.28e-01 | 0.1154 |
54471 | MIEF1 | P80T-E | Human | Esophagus | ESCC | 1.57e-15 | 2.70e-01 | 0.155 |
54471 | MIEF1 | P82T-E | Human | Esophagus | ESCC | 1.93e-05 | 2.52e-01 | 0.1072 |
54471 | MIEF1 | P83T-E | Human | Esophagus | ESCC | 1.36e-17 | 4.51e-01 | 0.1738 |
54471 | MIEF1 | P89T-E | Human | Esophagus | ESCC | 1.96e-04 | 2.45e-01 | 0.1752 |
54471 | MIEF1 | P91T-E | Human | Esophagus | ESCC | 3.19e-05 | 4.14e-01 | 0.1828 |
54471 | MIEF1 | P104T-E | Human | Esophagus | ESCC | 3.73e-03 | 8.64e-02 | 0.0931 |
54471 | MIEF1 | P107T-E | Human | Esophagus | ESCC | 3.21e-15 | 3.49e-01 | 0.171 |
54471 | MIEF1 | P126T-E | Human | Esophagus | ESCC | 1.10e-04 | 2.66e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:1905477 | Colorectum | AD | positive regulation of protein localization to membrane | 46/3918 | 106/18723 | 1.47e-07 | 6.64e-06 | 46 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0010821 | Colorectum | AD | regulation of mitochondrion organization | 57/3918 | 144/18723 | 2.43e-07 | 9.92e-06 | 57 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:0010822 | Colorectum | AD | positive regulation of mitochondrion organization | 32/3918 | 74/18723 | 1.22e-05 | 2.68e-04 | 32 |
GO:1903533 | Colorectum | AD | regulation of protein targeting | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0071453 | Colorectum | AD | cellular response to oxygen levels | 55/3918 | 177/18723 | 9.48e-04 | 8.96e-03 | 55 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0036293 | Colorectum | AD | response to decreased oxygen levels | 88/3918 | 322/18723 | 3.42e-03 | 2.49e-02 | 88 |
GO:19038292 | Colorectum | MSS | positive regulation of cellular protein localization | 103/3467 | 276/18723 | 1.12e-13 | 2.67e-11 | 103 |
GO:19049512 | Colorectum | MSS | positive regulation of establishment of protein localization | 110/3467 | 319/18723 | 6.30e-12 | 9.83e-10 | 110 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIEF1 | SNV | Missense_Mutation | c.1109T>C | p.Ile370Thr | p.I370T | protein_coding | tolerated(0.07) | benign(0.158) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
MIEF1 | SNV | Missense_Mutation | novel | c.1162N>C | p.Val388Leu | p.V388L | protein_coding | tolerated(0.11) | benign(0.049) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR | |
MIEF1 | SNV | Missense_Mutation | rs746975740 | c.1079G>A | p.Arg360Gln | p.R360Q | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MIEF1 | SNV | Missense_Mutation | novel | c.1049N>A | p.Arg350Gln | p.R350Q | protein_coding | tolerated(0.24) | possibly_damaging(0.552) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MIEF1 | SNV | Missense_Mutation | rs775912326 | c.1236G>C | p.Leu412Phe | p.L412F | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MIEF1 | SNV | Missense_Mutation | c.1248C>G | p.Ile416Met | p.I416M | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | ||
MIEF1 | SNV | Missense_Mutation | c.418N>G | p.Leu140Val | p.L140V | protein_coding | deleterious(0.04) | benign(0.079) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIEF1 | SNV | Missense_Mutation | novel | c.128N>T | p.Thr43Met | p.T43M | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MIEF1 | SNV | Missense_Mutation | c.506N>A | p.Arg169Gln | p.R169Q | protein_coding | tolerated(1) | possibly_damaging(0.704) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MIEF1 | SNV | Missense_Mutation | novel | c.1307N>C | p.Lys436Thr | p.K436T | protein_coding | tolerated(0.61) | benign(0.021) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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