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Gene: MGP |
Gene summary for MGP |
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Gene information | Species | Human | Gene symbol | MGP | Gene ID | 4256 |
Gene name | matrix Gla protein | |
Gene Alias | GIG36 | |
Cytomap | 12p12.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A024RAX0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4256 | MGP | AEH-subject1 | Human | Endometrium | AEH | 6.13e-15 | -6.01e-01 | -0.3059 |
4256 | MGP | AEH-subject2 | Human | Endometrium | AEH | 2.44e-17 | -6.14e-01 | -0.2525 |
4256 | MGP | AEH-subject3 | Human | Endometrium | AEH | 2.05e-21 | -6.96e-01 | -0.2576 |
4256 | MGP | AEH-subject4 | Human | Endometrium | AEH | 5.68e-10 | -5.55e-01 | -0.2657 |
4256 | MGP | AEH-subject5 | Human | Endometrium | AEH | 1.05e-16 | -6.31e-01 | -0.2953 |
4256 | MGP | EEC-subject1 | Human | Endometrium | EEC | 1.54e-31 | -7.89e-01 | -0.2682 |
4256 | MGP | EEC-subject2 | Human | Endometrium | EEC | 3.07e-28 | -7.69e-01 | -0.2607 |
4256 | MGP | EEC-subject3 | Human | Endometrium | EEC | 1.82e-15 | -2.97e-01 | -0.2525 |
4256 | MGP | EEC-subject4 | Human | Endometrium | EEC | 1.94e-15 | -5.56e-01 | -0.2571 |
4256 | MGP | EEC-subject5 | Human | Endometrium | EEC | 1.21e-17 | -6.13e-01 | -0.249 |
4256 | MGP | GSM5276934 | Human | Endometrium | EEC | 2.07e-03 | -3.19e-01 | -0.0913 |
4256 | MGP | GSM5276935 | Human | Endometrium | EEC | 1.23e-32 | -8.34e-01 | -0.123 |
4256 | MGP | GSM5276937 | Human | Endometrium | EEC | 3.36e-03 | 1.93e-02 | -0.0897 |
4256 | MGP | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.31e-33 | -8.28e-01 | -0.1869 |
4256 | MGP | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 5.57e-34 | -8.64e-01 | -0.1875 |
4256 | MGP | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.22e-39 | -8.64e-01 | -0.1883 |
4256 | MGP | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.71e-41 | -8.38e-01 | -0.1934 |
4256 | MGP | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.86e-46 | -8.64e-01 | -0.1917 |
4256 | MGP | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.05e-49 | -8.64e-01 | -0.1916 |
4256 | MGP | LZE2T | Human | Esophagus | ESCC | 3.22e-15 | 2.08e+00 | 0.082 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00015036 | Breast | Precancer | ossification | 36/1080 | 408/18723 | 7.53e-03 | 4.98e-02 | 36 |
GO:000150311 | Breast | IDC | ossification | 50/1434 | 408/18723 | 6.51e-04 | 8.04e-03 | 50 |
GO:000150321 | Breast | DCIS | ossification | 45/1390 | 408/18723 | 4.98e-03 | 3.72e-02 | 45 |
GO:00015038 | Endometrium | AEH | ossification | 78/2100 | 408/18723 | 1.54e-06 | 4.85e-05 | 78 |
GO:0061448 | Endometrium | AEH | connective tissue development | 44/2100 | 252/18723 | 1.92e-03 | 1.51e-02 | 44 |
GO:0070167 | Endometrium | AEH | regulation of biomineral tissue development | 20/2100 | 97/18723 | 5.00e-03 | 3.14e-02 | 20 |
GO:00302822 | Endometrium | AEH | bone mineralization | 23/2100 | 119/18723 | 6.32e-03 | 3.75e-02 | 23 |
GO:0110149 | Endometrium | AEH | regulation of biomineralization | 20/2100 | 99/18723 | 6.34e-03 | 3.76e-02 | 20 |
GO:00312141 | Endometrium | AEH | biomineral tissue development | 30/2100 | 169/18723 | 7.31e-03 | 4.18e-02 | 30 |
GO:01101481 | Endometrium | AEH | biomineralization | 30/2100 | 171/18723 | 8.63e-03 | 4.71e-02 | 30 |
GO:000150313 | Endometrium | EEC | ossification | 79/2168 | 408/18723 | 2.72e-06 | 7.67e-05 | 79 |
GO:00614481 | Endometrium | EEC | connective tissue development | 44/2168 | 252/18723 | 3.51e-03 | 2.36e-02 | 44 |
GO:00701671 | Endometrium | EEC | regulation of biomineral tissue development | 20/2168 | 97/18723 | 7.11e-03 | 4.07e-02 | 20 |
GO:01101491 | Endometrium | EEC | regulation of biomineralization | 20/2168 | 99/18723 | 8.95e-03 | 4.81e-02 | 20 |
GO:00302821 | Endometrium | EEC | bone mineralization | 23/2168 | 119/18723 | 9.19e-03 | 4.94e-02 | 23 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:00487052 | Esophagus | ESCC | skeletal system morphogenesis | 120/8552 | 220/18723 | 4.90e-03 | 1.89e-02 | 120 |
GO:00512161 | Esophagus | ESCC | cartilage development | 103/8552 | 190/18723 | 1.08e-02 | 3.67e-02 | 103 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:000150331 | Oral cavity | NEOLP | ossification | 81/2005 | 408/18723 | 2.67e-08 | 1.15e-06 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGP | SNV | Missense_Mutation | rs112598629 | c.43N>T | p.Val15Leu | p.V15L | P08493 | protein_coding | tolerated(0.11) | benign(0.041) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | rs112598629 | c.43N>T | p.Val15Leu | p.V15L | P08493 | protein_coding | tolerated(0.11) | benign(0.041) | TCGA-AO-A0JE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
MGP | SNV | Missense_Mutation | rs112598629 | c.43G>T | p.Val15Leu | p.V15L | P08493 | protein_coding | tolerated(0.11) | benign(0.041) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR |
MGP | insertion | Frame_Shift_Ins | novel | c.334_335insCACC | p.Gly112AlafsTer8 | p.G112Afs*8 | P08493 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
MGP | insertion | Frame_Shift_Ins | novel | c.333_334insATTCTCTTGTCTGGCT | p.Gly112IlefsTer12 | p.G112Ifs*12 | P08493 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
MGP | SNV | Missense_Mutation | novel | c.113C>T | p.Ser38Phe | p.S38F | P08493 | protein_coding | tolerated_low_confidence(0.1) | benign(0.364) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | c.256C>T | p.Arg86Cys | p.R86C | P08493 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MGP | SNV | Missense_Mutation | rs550754490 | c.274N>A | p.Glu92Lys | p.E92K | P08493 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | rs753350275 | c.316C>T | p.Arg106Cys | p.R106C | P08493 | protein_coding | tolerated(0.17) | probably_damaging(0.983) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MGP | SNV | Missense_Mutation | rs753350275 | c.316N>T | p.Arg106Cys | p.R106C | P08493 | protein_coding | tolerated(0.17) | probably_damaging(0.983) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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