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Gene: MGAT1 |
Gene summary for MGAT1 |
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Gene information | Species | Human | Gene symbol | MGAT1 | Gene ID | 4245 |
Gene name | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | |
Gene Alias | GLCNAC-TI | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | P26572 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4245 | MGAT1 | P22T-E | Human | Esophagus | ESCC | 4.15e-29 | 5.65e-01 | 0.1236 |
4245 | MGAT1 | P23T-E | Human | Esophagus | ESCC | 1.31e-34 | 1.05e+00 | 0.108 |
4245 | MGAT1 | P24T-E | Human | Esophagus | ESCC | 2.56e-15 | 4.02e-01 | 0.1287 |
4245 | MGAT1 | P26T-E | Human | Esophagus | ESCC | 2.88e-29 | 4.16e-01 | 0.1276 |
4245 | MGAT1 | P27T-E | Human | Esophagus | ESCC | 8.91e-16 | 3.26e-01 | 0.1055 |
4245 | MGAT1 | P28T-E | Human | Esophagus | ESCC | 2.85e-47 | 8.72e-01 | 0.1149 |
4245 | MGAT1 | P30T-E | Human | Esophagus | ESCC | 5.93e-21 | 8.17e-01 | 0.137 |
4245 | MGAT1 | P31T-E | Human | Esophagus | ESCC | 1.98e-16 | 2.05e-01 | 0.1251 |
4245 | MGAT1 | P32T-E | Human | Esophagus | ESCC | 1.63e-33 | 7.22e-01 | 0.1666 |
4245 | MGAT1 | P36T-E | Human | Esophagus | ESCC | 1.34e-13 | 5.76e-01 | 0.1187 |
4245 | MGAT1 | P37T-E | Human | Esophagus | ESCC | 2.92e-19 | 4.90e-01 | 0.1371 |
4245 | MGAT1 | P38T-E | Human | Esophagus | ESCC | 2.44e-11 | 3.72e-01 | 0.127 |
4245 | MGAT1 | P39T-E | Human | Esophagus | ESCC | 3.77e-13 | 2.27e-01 | 0.0894 |
4245 | MGAT1 | P40T-E | Human | Esophagus | ESCC | 2.97e-15 | 5.98e-01 | 0.109 |
4245 | MGAT1 | P42T-E | Human | Esophagus | ESCC | 3.27e-16 | 4.47e-01 | 0.1175 |
4245 | MGAT1 | P44T-E | Human | Esophagus | ESCC | 2.27e-09 | 5.35e-01 | 0.1096 |
4245 | MGAT1 | P47T-E | Human | Esophagus | ESCC | 2.82e-12 | 2.94e-01 | 0.1067 |
4245 | MGAT1 | P48T-E | Human | Esophagus | ESCC | 4.52e-21 | 3.36e-01 | 0.0959 |
4245 | MGAT1 | P49T-E | Human | Esophagus | ESCC | 1.90e-08 | 1.34e+00 | 0.1768 |
4245 | MGAT1 | P52T-E | Human | Esophagus | ESCC | 1.62e-22 | 6.89e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0019080 | Colorectum | AD | viral gene expression | 42/3918 | 94/18723 | 1.90e-07 | 8.02e-06 | 42 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0018279 | Colorectum | AD | protein N-linked glycosylation via asparagine | 15/3918 | 23/18723 | 5.47e-06 | 1.40e-04 | 15 |
GO:0019082 | Colorectum | AD | viral protein processing | 17/3918 | 29/18723 | 1.04e-05 | 2.40e-04 | 17 |
GO:0018196 | Colorectum | AD | peptidyl-asparagine modification | 15/3918 | 24/18723 | 1.18e-05 | 2.62e-04 | 15 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0006487 | Colorectum | AD | protein N-linked glycosylation | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0009225 | Colorectum | AD | nucleotide-sugar metabolic process | 16/3918 | 36/18723 | 1.27e-03 | 1.12e-02 | 16 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00190801 | Colorectum | SER | viral gene expression | 29/2897 | 94/18723 | 1.32e-04 | 2.66e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00510 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa005101 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa005102 | Colorectum | MSS | N-Glycan biosynthesis | 20/1875 | 53/8465 | 7.17e-03 | 2.83e-02 | 1.73e-02 | 20 |
hsa00513 | Colorectum | MSS | Various types of N-glycan biosynthesis | 16/1875 | 42/8465 | 1.39e-02 | 4.53e-02 | 2.77e-02 | 16 |
hsa005103 | Colorectum | MSS | N-Glycan biosynthesis | 20/1875 | 53/8465 | 7.17e-03 | 2.83e-02 | 1.73e-02 | 20 |
hsa005131 | Colorectum | MSS | Various types of N-glycan biosynthesis | 16/1875 | 42/8465 | 1.39e-02 | 4.53e-02 | 2.77e-02 | 16 |
hsa0051023 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa005136 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa0051033 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa0051313 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa005104 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa005134 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0051011 | Liver | Cirrhotic | N-Glycan biosynthesis | 32/2530 | 53/8465 | 3.82e-06 | 4.10e-05 | 2.53e-05 | 32 |
hsa0051311 | Liver | Cirrhotic | Various types of N-glycan biosynthesis | 26/2530 | 42/8465 | 1.65e-05 | 1.41e-04 | 8.69e-05 | 26 |
hsa0051021 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa005132 | Liver | HCC | Various types of N-glycan biosynthesis | 30/4020 | 42/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 30 |
hsa0051031 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa005133 | Liver | HCC | Various types of N-glycan biosynthesis | 30/4020 | 42/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 30 |
hsa005105 | Oral cavity | OSCC | N-Glycan biosynthesis | 39/3704 | 53/8465 | 9.77e-06 | 4.36e-05 | 2.22e-05 | 39 |
hsa005135 | Oral cavity | OSCC | Various types of N-glycan biosynthesis | 29/3704 | 42/8465 | 8.03e-04 | 2.32e-03 | 1.18e-03 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGAT1 | SNV | Missense_Mutation | rs778419570 | c.142N>A | p.Ala48Thr | p.A48T | P26572 | protein_coding | benign(0.006) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MGAT1 | SNV | Missense_Mutation | c.1079C>T | p.Ala360Val | p.A360V | P26572 | protein_coding | benign(0.106) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MGAT1 | SNV | Missense_Mutation | novel | c.920N>C | p.Glu307Ala | p.E307A | P26572 | protein_coding | probably_damaging(1) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MGAT1 | SNV | Missense_Mutation | novel | c.1130N>G | p.Asp377Gly | p.D377G | P26572 | protein_coding | benign(0.024) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MGAT1 | SNV | Missense_Mutation | c.623T>A | p.Val208Glu | p.V208E | P26572 | protein_coding | probably_damaging(0.993) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MGAT1 | SNV | Missense_Mutation | rs368412689 | c.1166C>T | p.Thr389Met | p.T389M | P26572 | protein_coding | possibly_damaging(0.734) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MGAT1 | SNV | Missense_Mutation | rs765702663 | c.457G>A | p.Ala153Thr | p.A153T | P26572 | protein_coding | benign(0.18) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MGAT1 | SNV | Missense_Mutation | c.947G>A | p.Arg316His | p.R316H | P26572 | protein_coding | probably_damaging(0.983) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MGAT1 | SNV | Missense_Mutation | rs761737308 | c.989N>G | p.Lys330Arg | p.K330R | P26572 | protein_coding | benign(0.031) | TCGA-AH-6643-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
MGAT1 | SNV | Missense_Mutation | c.419N>A | p.Ser140Asn | p.S140N | P26572 | protein_coding | probably_damaging(0.995) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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