Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/MCF2L2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MCF2L2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/MCF2L2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/MCF2L2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCF2L2 | SNV | Missense_Mutation | rs775278339 | c.574N>T | p.Arg192Cys | p.R192C | Q86YR7 | protein_coding | tolerated(1) | benign(0.013) | TCGA-A2-A0SY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD |
MCF2L2 | SNV | Missense_Mutation | novel | c.2686N>T | p.His896Tyr | p.H896Y | Q86YR7 | protein_coding | deleterious(0.01) | benign(0.139) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
MCF2L2 | SNV | Missense_Mutation | | c.2723T>A | p.Leu908His | p.L908H | Q86YR7 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
MCF2L2 | SNV | Missense_Mutation | | c.2321N>G | p.Ser774Cys | p.S774C | Q86YR7 | protein_coding | deleterious(0) | possibly_damaging(0.819) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MCF2L2 | SNV | Missense_Mutation | | c.2032N>A | p.Glu678Lys | p.E678K | Q86YR7 | protein_coding | deleterious(0.02) | probably_damaging(0.913) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCF2L2 | SNV | Missense_Mutation | novel | c.2736N>C | p.Gln912His | p.Q912H | Q86YR7 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCF2L2 | SNV | Missense_Mutation | | c.3090G>T | p.Glu1030Asp | p.E1030D | Q86YR7 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-D8-A1X5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
MCF2L2 | SNV | Missense_Mutation | | c.2939N>G | p.Ser980Cys | p.S980C | Q86YR7 | protein_coding | tolerated(0.19) | benign(0) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | | SD |
MCF2L2 | deletion | Frame_Shift_Del | novel | c.2763delN | p.Phe921LeufsTer29 | p.F921Lfs*29 | Q86YR7 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
MCF2L2 | deletion | Frame_Shift_Del | rs748576542 | c.1095delN | p.Lys365AsnfsTer59 | p.K365Nfs*59 | Q86YR7 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |