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Gene: LRRC57 |
Gene summary for LRRC57 |
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Gene information | Species | Human | Gene symbol | LRRC57 | Gene ID | 255252 |
Gene name | leucine rich repeat containing 57 | |
Gene Alias | LRRC57 | |
Cytomap | 15q15.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R9M3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
255252 | LRRC57 | P76T-E | Human | Esophagus | ESCC | 4.42e-15 | 2.69e-01 | 0.1207 |
255252 | LRRC57 | P79T-E | Human | Esophagus | ESCC | 2.05e-10 | 1.96e-01 | 0.1154 |
255252 | LRRC57 | P80T-E | Human | Esophagus | ESCC | 3.52e-18 | 4.37e-01 | 0.155 |
255252 | LRRC57 | P82T-E | Human | Esophagus | ESCC | 5.14e-07 | 4.65e-01 | 0.1072 |
255252 | LRRC57 | P83T-E | Human | Esophagus | ESCC | 3.96e-10 | 3.40e-01 | 0.1738 |
255252 | LRRC57 | P89T-E | Human | Esophagus | ESCC | 2.54e-06 | 2.62e-01 | 0.1752 |
255252 | LRRC57 | P91T-E | Human | Esophagus | ESCC | 9.13e-04 | 5.83e-01 | 0.1828 |
255252 | LRRC57 | P107T-E | Human | Esophagus | ESCC | 2.52e-10 | 3.02e-01 | 0.171 |
255252 | LRRC57 | P126T-E | Human | Esophagus | ESCC | 8.49e-06 | 3.60e-01 | 0.1125 |
255252 | LRRC57 | P127T-E | Human | Esophagus | ESCC | 6.88e-08 | 1.16e-01 | 0.0826 |
255252 | LRRC57 | P128T-E | Human | Esophagus | ESCC | 1.24e-13 | 4.33e-01 | 0.1241 |
255252 | LRRC57 | P130T-E | Human | Esophagus | ESCC | 3.16e-24 | 4.17e-01 | 0.1676 |
255252 | LRRC57 | HCC1_Meng | Human | Liver | HCC | 9.56e-23 | -4.51e-03 | 0.0246 |
255252 | LRRC57 | HCC2_Meng | Human | Liver | HCC | 9.53e-06 | 2.76e-02 | 0.0107 |
255252 | LRRC57 | HCC1 | Human | Liver | HCC | 4.36e-10 | 2.38e+00 | 0.5336 |
255252 | LRRC57 | HCC2 | Human | Liver | HCC | 8.02e-20 | 2.96e+00 | 0.5341 |
255252 | LRRC57 | HCC5 | Human | Liver | HCC | 2.01e-08 | 1.21e+00 | 0.4932 |
255252 | LRRC57 | S014 | Human | Liver | HCC | 6.13e-05 | 2.43e-01 | 0.2254 |
255252 | LRRC57 | S015 | Human | Liver | HCC | 8.99e-06 | 3.41e-01 | 0.2375 |
255252 | LRRC57 | S016 | Human | Liver | HCC | 4.16e-06 | 2.72e-01 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC57 | SNV | Missense_Mutation | novel | c.106N>G | p.Leu36Val | p.L36V | Q8N9N7 | protein_coding | deleterious(0.04) | benign(0.352) | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
LRRC57 | insertion | Nonsense_Mutation | novel | c.578_579insATATTTATCTTTCATGATAGACTAACTCTTTGAGGGCAAGG | p.Pro194TyrfsTer8 | p.P194Yfs*8 | Q8N9N7 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
LRRC57 | SNV | Missense_Mutation | c.679N>C | p.Tyr227His | p.Y227H | Q8N9N7 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRRC57 | SNV | Missense_Mutation | rs762279497 | c.284A>G | p.Asn95Ser | p.N95S | Q8N9N7 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-AG-3732-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | capecitabine | SD |
LRRC57 | SNV | Missense_Mutation | c.635T>A | p.Leu212His | p.L212H | Q8N9N7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
LRRC57 | SNV | Missense_Mutation | rs762719937 | c.529N>T | p.Arg177Cys | p.R177C | Q8N9N7 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LRRC57 | SNV | Missense_Mutation | c.431G>A | p.Arg144Gln | p.R144Q | Q8N9N7 | protein_coding | tolerated(0.49) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRRC57 | SNV | Missense_Mutation | novel | c.541N>A | p.Leu181Ile | p.L181I | Q8N9N7 | protein_coding | deleterious(0.02) | possibly_damaging(0.634) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC57 | SNV | Missense_Mutation | novel | c.42G>T | p.Gln14His | p.Q14H | Q8N9N7 | protein_coding | deleterious(0.01) | benign(0.275) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
LRRC57 | SNV | Missense_Mutation | novel | c.301N>T | p.Pro101Ser | p.P101S | Q8N9N7 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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