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Gene: LRR1 |
Gene summary for LRR1 |
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Gene information | Species | Human | Gene symbol | LRR1 | Gene ID | 122769 |
Gene name | leucine rich repeat protein 1 | |
Gene Alias | 4-1BBLRR | |
Cytomap | 14q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q6AWA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
122769 | LRR1 | P76T-E | Human | Esophagus | ESCC | 5.69e-06 | 2.21e-01 | 0.1207 |
122769 | LRR1 | P79T-E | Human | Esophagus | ESCC | 4.96e-06 | 2.26e-01 | 0.1154 |
122769 | LRR1 | P80T-E | Human | Esophagus | ESCC | 1.78e-07 | 3.66e-01 | 0.155 |
122769 | LRR1 | P82T-E | Human | Esophagus | ESCC | 7.62e-03 | 1.64e-01 | 0.1072 |
122769 | LRR1 | P83T-E | Human | Esophagus | ESCC | 7.97e-16 | 5.65e-01 | 0.1738 |
122769 | LRR1 | P89T-E | Human | Esophagus | ESCC | 3.72e-07 | 4.79e-01 | 0.1752 |
122769 | LRR1 | P91T-E | Human | Esophagus | ESCC | 1.60e-14 | 1.58e+00 | 0.1828 |
122769 | LRR1 | P107T-E | Human | Esophagus | ESCC | 2.14e-29 | 7.17e-01 | 0.171 |
122769 | LRR1 | P126T-E | Human | Esophagus | ESCC | 2.70e-02 | 2.83e-01 | 0.1125 |
122769 | LRR1 | P127T-E | Human | Esophagus | ESCC | 8.74e-07 | 5.19e-02 | 0.0826 |
122769 | LRR1 | P128T-E | Human | Esophagus | ESCC | 1.29e-26 | 8.63e-01 | 0.1241 |
122769 | LRR1 | P130T-E | Human | Esophagus | ESCC | 3.46e-29 | 6.54e-01 | 0.1676 |
122769 | LRR1 | C04 | Human | Oral cavity | OSCC | 1.63e-15 | 7.11e-01 | 0.2633 |
122769 | LRR1 | C21 | Human | Oral cavity | OSCC | 2.28e-23 | 7.22e-01 | 0.2678 |
122769 | LRR1 | C30 | Human | Oral cavity | OSCC | 2.10e-23 | 1.18e+00 | 0.3055 |
122769 | LRR1 | C38 | Human | Oral cavity | OSCC | 1.74e-04 | 4.70e-01 | 0.172 |
122769 | LRR1 | C43 | Human | Oral cavity | OSCC | 8.92e-14 | 3.47e-01 | 0.1704 |
122769 | LRR1 | C46 | Human | Oral cavity | OSCC | 1.22e-09 | 2.61e-01 | 0.1673 |
122769 | LRR1 | C51 | Human | Oral cavity | OSCC | 5.02e-07 | 4.73e-01 | 0.2674 |
122769 | LRR1 | C57 | Human | Oral cavity | OSCC | 1.94e-04 | 2.47e-01 | 0.1679 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRR1 | SNV | Missense_Mutation | novel | c.283N>A | p.Ala95Thr | p.A95T | Q96L50 | protein_coding | deleterious(0) | benign(0.417) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRR1 | SNV | Missense_Mutation | c.775N>G | p.Asn259Asp | p.N259D | Q96L50 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRR1 | SNV | Missense_Mutation | rs777354325 | c.259N>T | p.Pro87Ser | p.P87S | Q96L50 | protein_coding | tolerated(0.1) | benign(0.049) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
LRR1 | SNV | Missense_Mutation | novel | c.155N>C | p.Leu52Pro | p.L52P | Q96L50 | protein_coding | tolerated(0.24) | benign(0.276) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
LRR1 | SNV | Missense_Mutation | c.464N>G | p.Ser155Cys | p.S155C | Q96L50 | protein_coding | deleterious(0) | possibly_damaging(0.594) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
LRR1 | SNV | Missense_Mutation | novel | c.997N>A | p.His333Asn | p.H333N | Q96L50 | protein_coding | tolerated(0.79) | benign(0) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
LRR1 | SNV | Missense_Mutation | rs777495090 | c.514C>T | p.Arg172Cys | p.R172C | Q96L50 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-2671-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Other, specify in notesProtocol AMG 20060464 | study | PD |
LRR1 | SNV | Missense_Mutation | c.737G>A | p.Cys246Tyr | p.C246Y | Q96L50 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
LRR1 | SNV | Missense_Mutation | rs777495090 | c.514N>T | p.Arg172Cys | p.R172C | Q96L50 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LRR1 | SNV | Missense_Mutation | novel | c.901N>A | p.Leu301Ile | p.L301I | Q96L50 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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