![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LMO7 |
Gene summary for LMO7 |
![]() |
Gene information | Species | Human | Gene symbol | LMO7 | Gene ID | 4008 |
Gene name | LIM domain 7 | |
Gene Alias | FBX20 | |
Cytomap | 13q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | F8J2B5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4008 | LMO7 | LZE7T | Human | Esophagus | ESCC | 2.07e-04 | 4.90e-01 | 0.0667 |
4008 | LMO7 | LZE20T | Human | Esophagus | ESCC | 3.19e-05 | 5.63e-01 | 0.0662 |
4008 | LMO7 | LZE22D1 | Human | Esophagus | HGIN | 3.45e-07 | 1.53e-01 | 0.0595 |
4008 | LMO7 | LZE22T | Human | Esophagus | ESCC | 1.39e-04 | 1.55e+00 | 0.068 |
4008 | LMO7 | LZE24T | Human | Esophagus | ESCC | 2.78e-34 | 1.51e+00 | 0.0596 |
4008 | LMO7 | P1T-E | Human | Esophagus | ESCC | 1.03e-05 | 1.19e+00 | 0.0875 |
4008 | LMO7 | P2T-E | Human | Esophagus | ESCC | 1.19e-17 | 3.91e-01 | 0.1177 |
4008 | LMO7 | P4T-E | Human | Esophagus | ESCC | 1.00e-07 | 2.47e-01 | 0.1323 |
4008 | LMO7 | P5T-E | Human | Esophagus | ESCC | 7.26e-03 | 3.13e-02 | 0.1327 |
4008 | LMO7 | P8T-E | Human | Esophagus | ESCC | 7.14e-63 | 1.48e+00 | 0.0889 |
4008 | LMO7 | P9T-E | Human | Esophagus | ESCC | 1.03e-10 | 4.16e-01 | 0.1131 |
4008 | LMO7 | P10T-E | Human | Esophagus | ESCC | 3.30e-35 | 7.29e-01 | 0.116 |
4008 | LMO7 | P11T-E | Human | Esophagus | ESCC | 1.75e-06 | 2.59e-01 | 0.1426 |
4008 | LMO7 | P12T-E | Human | Esophagus | ESCC | 5.14e-28 | 6.95e-01 | 0.1122 |
4008 | LMO7 | P15T-E | Human | Esophagus | ESCC | 1.27e-03 | 1.17e-01 | 0.1149 |
4008 | LMO7 | P16T-E | Human | Esophagus | ESCC | 8.09e-13 | -1.00e-02 | 0.1153 |
4008 | LMO7 | P21T-E | Human | Esophagus | ESCC | 3.25e-03 | 1.29e-01 | 0.1617 |
4008 | LMO7 | P23T-E | Human | Esophagus | ESCC | 3.70e-23 | 1.70e+00 | 0.108 |
4008 | LMO7 | P24T-E | Human | Esophagus | ESCC | 1.80e-18 | 2.30e-01 | 0.1287 |
4008 | LMO7 | P26T-E | Human | Esophagus | ESCC | 6.42e-21 | 3.22e-01 | 0.1276 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0452014 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452015 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452022 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452032 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452042 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LMO7 | SNV | Missense_Mutation | rs190179934 | c.1771N>T | p.Arg591Cys | p.R591C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.255N>C | p.Leu85Phe | p.L85F | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR | |
LMO7 | SNV | Missense_Mutation | c.3701G>A | p.Ser1234Asn | p.S1234N | protein_coding | tolerated(0.16) | benign(0.023) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LMO7 | SNV | Missense_Mutation | novel | c.4529N>A | p.Pro1510His | p.P1510H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.2328N>A | p.Ser776Arg | p.S776R | protein_coding | tolerated(0.07) | benign(0.171) | TCGA-BH-A1FM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | rs775633721 | c.3550A>G | p.Arg1184Gly | p.R1184G | protein_coding | deleterious(0) | benign(0.082) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.1481N>C | p.Val494Ala | p.V494A | protein_coding | tolerated(0.09) | benign(0.445) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LMO7 | insertion | Frame_Shift_Ins | novel | c.2809_2810insGAATTGGATGGTGTTGGCTGTGTCTGATGCAGGAAATACACTG | p.Pro937ArgfsTer31 | p.P937Rfs*31 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
LMO7 | insertion | In_Frame_Ins | novel | c.1275_1276insAAA | p.Pro425_Thr426insLys | p.P425_T426insK | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||||
LMO7 | insertion | Frame_Shift_Ins | novel | c.1277_1278insCCAACTTAAATTAGGCAAACAAGCAAGTAATAACCGA | p.Ser427GlnfsTer31 | p.S427Qfs*31 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |