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Gene: LINC00869 |
Gene summary for LINC00869 |
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Gene information | Species | Human | Gene symbol | LINC00869 | Gene ID | 57234 |
Gene name | long intergenic non-protein coding RNA 869 | |
Gene Alias | FAM91A2 | |
Cytomap | 1q21.2 | |
Gene Type | ncRNA | GO ID | GO:0006810 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57234 | LINC00869 | P12T-E | Human | Esophagus | ESCC | 6.18e-04 | 1.71e-02 | 0.1122 |
57234 | LINC00869 | P15T-E | Human | Esophagus | ESCC | 3.83e-09 | 1.84e-01 | 0.1149 |
57234 | LINC00869 | P16T-E | Human | Esophagus | ESCC | 1.40e-07 | 1.78e-01 | 0.1153 |
57234 | LINC00869 | P17T-E | Human | Esophagus | ESCC | 1.62e-03 | 2.72e-01 | 0.1278 |
57234 | LINC00869 | P19T-E | Human | Esophagus | ESCC | 2.91e-03 | 3.48e-01 | 0.1662 |
57234 | LINC00869 | P20T-E | Human | Esophagus | ESCC | 3.96e-09 | 2.45e-01 | 0.1124 |
57234 | LINC00869 | P21T-E | Human | Esophagus | ESCC | 2.75e-03 | 2.54e-02 | 0.1617 |
57234 | LINC00869 | P22T-E | Human | Esophagus | ESCC | 1.54e-07 | 1.24e-01 | 0.1236 |
57234 | LINC00869 | P23T-E | Human | Esophagus | ESCC | 1.00e-03 | 1.85e-01 | 0.108 |
57234 | LINC00869 | P24T-E | Human | Esophagus | ESCC | 1.57e-20 | 4.58e-01 | 0.1287 |
57234 | LINC00869 | P26T-E | Human | Esophagus | ESCC | 1.16e-07 | 1.20e-01 | 0.1276 |
57234 | LINC00869 | P27T-E | Human | Esophagus | ESCC | 5.12e-09 | 1.28e-01 | 0.1055 |
57234 | LINC00869 | P28T-E | Human | Esophagus | ESCC | 1.35e-13 | 2.52e-01 | 0.1149 |
57234 | LINC00869 | P30T-E | Human | Esophagus | ESCC | 2.90e-05 | 1.31e-01 | 0.137 |
57234 | LINC00869 | P32T-E | Human | Esophagus | ESCC | 1.18e-12 | 2.77e-01 | 0.1666 |
57234 | LINC00869 | P36T-E | Human | Esophagus | ESCC | 1.17e-07 | 3.58e-01 | 0.1187 |
57234 | LINC00869 | P37T-E | Human | Esophagus | ESCC | 3.00e-06 | 1.51e-01 | 0.1371 |
57234 | LINC00869 | P39T-E | Human | Esophagus | ESCC | 2.50e-05 | 3.74e-02 | 0.0894 |
57234 | LINC00869 | P40T-E | Human | Esophagus | ESCC | 1.43e-04 | 1.65e-01 | 0.109 |
57234 | LINC00869 | P42T-E | Human | Esophagus | ESCC | 2.28e-06 | 1.77e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0006903 | Colorectum | AD | vesicle targeting | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00516501 | Colorectum | SER | establishment of vesicle localization | 42/2897 | 161/18723 | 3.38e-04 | 5.35e-03 | 42 |
GO:00516481 | Colorectum | SER | vesicle localization | 43/2897 | 177/18723 | 1.41e-03 | 1.53e-02 | 43 |
GO:00069031 | Colorectum | SER | vesicle targeting | 14/2897 | 45/18723 | 6.36e-03 | 4.57e-02 | 14 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00516502 | Colorectum | MSS | establishment of vesicle localization | 51/3467 | 161/18723 | 3.92e-05 | 7.45e-04 | 51 |
GO:00516482 | Colorectum | MSS | vesicle localization | 53/3467 | 177/18723 | 1.47e-04 | 2.16e-03 | 53 |
GO:00069032 | Colorectum | MSS | vesicle targeting | 17/3467 | 45/18723 | 1.89e-03 | 1.65e-02 | 17 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00069038 | Esophagus | ESCC | vesicle targeting | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:00990222 | Esophagus | ESCC | vesicle tethering | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:00069037 | Oral cavity | OSCC | vesicle targeting | 38/7305 | 45/18723 | 4.49e-10 | 1.19e-08 | 38 |
GO:00516509 | Oral cavity | OSCC | establishment of vesicle localization | 101/7305 | 161/18723 | 8.79e-10 | 2.17e-08 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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