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Gene: KCTD11 |
Gene summary for KCTD11 |
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Gene information | Species | Human | Gene symbol | KCTD11 | Gene ID | 147040 |
Gene name | potassium channel tetramerization domain containing 11 | |
Gene Alias | C17orf36 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A158RFT7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147040 | KCTD11 | P75T-E | Human | Esophagus | ESCC | 8.80e-28 | 5.12e-01 | 0.1125 |
147040 | KCTD11 | P76T-E | Human | Esophagus | ESCC | 6.05e-05 | 2.15e-01 | 0.1207 |
147040 | KCTD11 | P79T-E | Human | Esophagus | ESCC | 7.74e-10 | 1.76e-01 | 0.1154 |
147040 | KCTD11 | P80T-E | Human | Esophagus | ESCC | 1.09e-04 | 1.04e-01 | 0.155 |
147040 | KCTD11 | P82T-E | Human | Esophagus | ESCC | 4.09e-02 | 3.60e-01 | 0.1072 |
147040 | KCTD11 | P83T-E | Human | Esophagus | ESCC | 1.36e-20 | 6.26e-01 | 0.1738 |
147040 | KCTD11 | P84T-E | Human | Esophagus | ESCC | 6.82e-08 | 6.45e-01 | 0.0933 |
147040 | KCTD11 | P89T-E | Human | Esophagus | ESCC | 9.73e-13 | 1.06e+00 | 0.1752 |
147040 | KCTD11 | P91T-E | Human | Esophagus | ESCC | 1.25e-08 | 1.47e+00 | 0.1828 |
147040 | KCTD11 | P107T-E | Human | Esophagus | ESCC | 1.44e-29 | 8.84e-01 | 0.171 |
147040 | KCTD11 | P127T-E | Human | Esophagus | ESCC | 3.81e-06 | 1.85e-01 | 0.0826 |
147040 | KCTD11 | P128T-E | Human | Esophagus | ESCC | 2.91e-13 | 4.70e-01 | 0.1241 |
147040 | KCTD11 | P130T-E | Human | Esophagus | ESCC | 2.86e-25 | 5.14e-01 | 0.1676 |
147040 | KCTD11 | C04 | Human | Oral cavity | OSCC | 1.86e-07 | 3.12e-01 | 0.2633 |
147040 | KCTD11 | C21 | Human | Oral cavity | OSCC | 1.25e-30 | 9.42e-01 | 0.2678 |
147040 | KCTD11 | C30 | Human | Oral cavity | OSCC | 2.87e-39 | 1.21e+00 | 0.3055 |
147040 | KCTD11 | C43 | Human | Oral cavity | OSCC | 3.95e-15 | 3.81e-01 | 0.1704 |
147040 | KCTD11 | C51 | Human | Oral cavity | OSCC | 7.40e-12 | 5.29e-01 | 0.2674 |
147040 | KCTD11 | C57 | Human | Oral cavity | OSCC | 8.17e-14 | 3.82e-01 | 0.1679 |
147040 | KCTD11 | C07 | Human | Oral cavity | OSCC | 4.77e-03 | 4.23e-01 | 0.2491 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:0051259 | Oral cavity | OSCC | protein complex oligomerization | 121/7305 | 238/18723 | 1.29e-04 | 9.21e-04 | 121 |
GO:00512591 | Oral cavity | LP | protein complex oligomerization | 85/4623 | 238/18723 | 8.81e-05 | 1.11e-03 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCTD11 | SNV | Missense_Mutation | c.202C>T | p.Pro68Ser | p.P68S | Q693B1 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCTD11 | SNV | Missense_Mutation | rs769368508 | c.419N>A | p.Arg140Gln | p.R140Q | Q693B1 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KCTD11 | SNV | Missense_Mutation | rs754017618 | c.349G>A | p.Val117Ile | p.V117I | Q693B1 | protein_coding | tolerated(0.07) | benign(0.017) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
KCTD11 | SNV | Missense_Mutation | rs865964999 | c.485N>A | p.Arg162His | p.R162H | Q693B1 | protein_coding | tolerated(0.16) | benign(0) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KCTD11 | SNV | Missense_Mutation | rs781114097 | c.100N>T | p.Arg34Trp | p.R34W | Q693B1 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-AY-6386-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fu | SD |
KCTD11 | SNV | Missense_Mutation | c.622G>A | p.Gly208Ser | p.G208S | Q693B1 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCTD11 | SNV | Missense_Mutation | c.11N>A | p.Ala4Asp | p.A4D | Q693B1 | protein_coding | deleterious(0) | benign(0.31) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KCTD11 | SNV | Missense_Mutation | novel | c.101N>A | p.Arg34Gln | p.R34Q | Q693B1 | protein_coding | deleterious(0.03) | benign(0.052) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KCTD11 | SNV | Missense_Mutation | c.274N>A | p.Ala92Thr | p.A92T | Q693B1 | protein_coding | tolerated(0.28) | possibly_damaging(0.639) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KCTD11 | SNV | Missense_Mutation | novel | c.353N>G | p.Gln118Arg | p.Q118R | Q693B1 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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