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Gene: ITGAE |
Gene summary for ITGAE |
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Gene information | Species | Human | Gene symbol | ITGAE | Gene ID | 3682 |
Gene name | integrin subunit alpha E | |
Gene Alias | CD103 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | P38570 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3682 | ITGAE | P44T-E | Human | Esophagus | ESCC | 5.33e-10 | 3.05e-01 | 0.1096 |
3682 | ITGAE | P47T-E | Human | Esophagus | ESCC | 4.95e-14 | 3.03e-01 | 0.1067 |
3682 | ITGAE | P48T-E | Human | Esophagus | ESCC | 2.72e-22 | 5.09e-01 | 0.0959 |
3682 | ITGAE | P49T-E | Human | Esophagus | ESCC | 1.01e-07 | 1.17e+00 | 0.1768 |
3682 | ITGAE | P52T-E | Human | Esophagus | ESCC | 1.95e-26 | 7.61e-01 | 0.1555 |
3682 | ITGAE | P54T-E | Human | Esophagus | ESCC | 8.45e-21 | 6.40e-01 | 0.0975 |
3682 | ITGAE | P57T-E | Human | Esophagus | ESCC | 3.01e-12 | 2.68e-01 | 0.0926 |
3682 | ITGAE | P61T-E | Human | Esophagus | ESCC | 2.69e-12 | 4.02e-01 | 0.099 |
3682 | ITGAE | P62T-E | Human | Esophagus | ESCC | 2.88e-37 | 8.76e-01 | 0.1302 |
3682 | ITGAE | P65T-E | Human | Esophagus | ESCC | 6.22e-19 | 5.74e-01 | 0.0978 |
3682 | ITGAE | P74T-E | Human | Esophagus | ESCC | 1.78e-37 | 1.31e+00 | 0.1479 |
3682 | ITGAE | P75T-E | Human | Esophagus | ESCC | 1.99e-27 | 5.72e-01 | 0.1125 |
3682 | ITGAE | P76T-E | Human | Esophagus | ESCC | 9.84e-38 | 8.58e-01 | 0.1207 |
3682 | ITGAE | P79T-E | Human | Esophagus | ESCC | 2.56e-36 | 8.25e-01 | 0.1154 |
3682 | ITGAE | P80T-E | Human | Esophagus | ESCC | 9.69e-29 | 9.81e-01 | 0.155 |
3682 | ITGAE | P82T-E | Human | Esophagus | ESCC | 1.30e-07 | 8.84e-01 | 0.1072 |
3682 | ITGAE | P83T-E | Human | Esophagus | ESCC | 2.12e-22 | 1.03e+00 | 0.1738 |
3682 | ITGAE | P84T-E | Human | Esophagus | ESCC | 8.78e-07 | 5.78e-01 | 0.0933 |
3682 | ITGAE | P89T-E | Human | Esophagus | ESCC | 6.45e-13 | 1.13e+00 | 0.1752 |
3682 | ITGAE | P91T-E | Human | Esophagus | ESCC | 1.09e-06 | 1.26e+00 | 0.1828 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072299 | Esophagus | ESCC | integrin-mediated signaling pathway | 67/8552 | 107/18723 | 3.03e-04 | 1.81e-03 | 67 |
GO:000722911 | Liver | Cirrhotic | integrin-mediated signaling pathway | 46/4634 | 107/18723 | 2.66e-05 | 3.42e-04 | 46 |
GO:00072292 | Liver | HCC | integrin-mediated signaling pathway | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
GO:00072298 | Oral cavity | OSCC | integrin-mediated signaling pathway | 58/7305 | 107/18723 | 1.00e-03 | 5.20e-03 | 58 |
GO:000722916 | Oral cavity | LP | integrin-mediated signaling pathway | 42/4623 | 107/18723 | 5.96e-04 | 5.46e-03 | 42 |
GO:000722924 | Skin | cSCC | integrin-mediated signaling pathway | 47/4864 | 107/18723 | 4.21e-05 | 4.43e-04 | 47 |
GO:000722918 | Thyroid | PTC | integrin-mediated signaling pathway | 55/5968 | 107/18723 | 2.07e-05 | 2.08e-04 | 55 |
GO:000722919 | Thyroid | ATC | integrin-mediated signaling pathway | 63/6293 | 107/18723 | 7.09e-08 | 1.24e-06 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0481026 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
hsa04810111 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Breast | DCIS |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Breast | Healthy |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Cervix | Precancer |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Endometrium | AEH |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Endometrium | Healthy |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | HNSCC | OSCC |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | HNSCC | Precancer |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Liver | HCC |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Liver | Precancer |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Prostate | BPH |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Prostate | Tumor |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Skin | ADJ |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | Skin | cSCC |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | THCA | Cancer |
CDH1 | ITGAE_ITGB7 | CDH1_ITGAE_ITGB7 | CDH1 | THCA | PTC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGAE | SNV | Missense_Mutation | rs530702065 | c.1586C>T | p.Thr529Met | p.T529M | P38570 | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
ITGAE | SNV | Missense_Mutation | rs143859925 | c.769N>T | p.Arg257Trp | p.R257W | P38570 | protein_coding | deleterious(0.01) | possibly_damaging(0.761) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ITGAE | SNV | Missense_Mutation | novel | c.3534N>T | p.Glu1178Asp | p.E1178D | P38570 | protein_coding | tolerated_low_confidence(0.37) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITGAE | SNV | Missense_Mutation | novel | c.1759N>A | p.Leu587Ile | p.L587I | P38570 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITGAE | SNV | Missense_Mutation | rs530702065 | c.1586N>T | p.Thr529Met | p.T529M | P38570 | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-BH-AB28-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
ITGAE | insertion | Nonsense_Mutation | novel | c.3242_3243insGTGAGTTCAATAGGGCCTGGAAGGTCAACCCTA | p.Leu1081_Lys1082insTer | p.L1081_K1082ins* | P38570 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ITGAE | insertion | Nonsense_Mutation | novel | c.2538_2539insAAACCCTGTTTCTATTAAAAATACAAAAAATTA | p.Val846_Gly847insLysProCysPheTyrTerLysTyrLysLysLeu | p.V846_G847insKPCFY*KYKKL | P38570 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ITGAE | insertion | Frame_Shift_Ins | novel | c.612_613insTCAGCCTCCCG | p.Ile205SerfsTer28 | p.I205Sfs*28 | P38570 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ITGAE | SNV | Missense_Mutation | novel | c.651N>A | p.Asp217Glu | p.D217E | P38570 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ITGAE | SNV | Missense_Mutation | c.1003G>A | p.Glu335Lys | p.E335K | P38570 | protein_coding | deleterious(0.04) | benign(0.205) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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