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Gene: INTS12 |
Gene summary for INTS12 |
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Gene information | Species | Human | Gene symbol | INTS12 | Gene ID | 57117 |
Gene name | integrator complex subunit 12 | |
Gene Alias | INT12 | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RDK4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57117 | INTS12 | P54T-E | Human | Esophagus | ESCC | 2.14e-15 | 2.44e-01 | 0.0975 |
57117 | INTS12 | P56T-E | Human | Esophagus | ESCC | 1.15e-03 | 5.95e-01 | 0.1613 |
57117 | INTS12 | P57T-E | Human | Esophagus | ESCC | 1.34e-19 | 2.14e-01 | 0.0926 |
57117 | INTS12 | P61T-E | Human | Esophagus | ESCC | 6.56e-11 | 2.17e-01 | 0.099 |
57117 | INTS12 | P62T-E | Human | Esophagus | ESCC | 2.87e-33 | 5.26e-01 | 0.1302 |
57117 | INTS12 | P65T-E | Human | Esophagus | ESCC | 2.95e-15 | 1.84e-01 | 0.0978 |
57117 | INTS12 | P74T-E | Human | Esophagus | ESCC | 3.04e-24 | 5.42e-01 | 0.1479 |
57117 | INTS12 | P75T-E | Human | Esophagus | ESCC | 2.49e-32 | 5.47e-01 | 0.1125 |
57117 | INTS12 | P76T-E | Human | Esophagus | ESCC | 5.20e-24 | 3.00e-01 | 0.1207 |
57117 | INTS12 | P79T-E | Human | Esophagus | ESCC | 4.87e-29 | 5.11e-01 | 0.1154 |
57117 | INTS12 | P80T-E | Human | Esophagus | ESCC | 4.72e-20 | 5.51e-01 | 0.155 |
57117 | INTS12 | P82T-E | Human | Esophagus | ESCC | 1.39e-13 | 5.20e-01 | 0.1072 |
57117 | INTS12 | P83T-E | Human | Esophagus | ESCC | 2.52e-27 | 6.59e-01 | 0.1738 |
57117 | INTS12 | P84T-E | Human | Esophagus | ESCC | 1.87e-11 | 3.52e-01 | 0.0933 |
57117 | INTS12 | P89T-E | Human | Esophagus | ESCC | 1.13e-11 | 7.99e-01 | 0.1752 |
57117 | INTS12 | P91T-E | Human | Esophagus | ESCC | 1.19e-10 | 8.78e-01 | 0.1828 |
57117 | INTS12 | P94T-E | Human | Esophagus | ESCC | 2.99e-03 | 3.56e-01 | 0.0879 |
57117 | INTS12 | P107T-E | Human | Esophagus | ESCC | 9.20e-19 | 4.36e-01 | 0.171 |
57117 | INTS12 | P126T-E | Human | Esophagus | ESCC | 2.88e-08 | 4.10e-01 | 0.1125 |
57117 | INTS12 | P127T-E | Human | Esophagus | ESCC | 8.45e-09 | 1.56e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:00311231 | Liver | HCC | RNA 3'-end processing | 81/7958 | 116/18723 | 2.27e-09 | 6.32e-08 | 81 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00311232 | Oral cavity | OSCC | RNA 3'-end processing | 75/7305 | 116/18723 | 1.93e-08 | 3.79e-07 | 75 |
GO:00344708 | Prostate | BPH | ncRNA processing | 84/3107 | 395/18723 | 8.44e-03 | 3.64e-02 | 84 |
GO:003447013 | Prostate | Tumor | ncRNA processing | 94/3246 | 395/18723 | 6.02e-04 | 4.31e-03 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INTS12 | SNV | Missense_Mutation | c.851C>G | p.Ser284Trp | p.S284W | Q96CB8 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A2-A0YM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INTS12 | SNV | Missense_Mutation | novel | c.122N>A | p.Arg41Gln | p.R41Q | Q96CB8 | protein_coding | tolerated(0.32) | benign(0.401) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
INTS12 | SNV | Missense_Mutation | c.507N>A | p.Met169Ile | p.M169I | Q96CB8 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | CR | ||
INTS12 | SNV | Missense_Mutation | c.1168C>T | p.Pro390Ser | p.P390S | Q96CB8 | protein_coding | tolerated_low_confidence(0.06) | benign(0.236) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INTS12 | SNV | Missense_Mutation | c.328N>A | p.Glu110Lys | p.E110K | Q96CB8 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
INTS12 | insertion | Nonsense_Mutation | novel | c.332_333insCTTTTAAATCTGTTATGTTGTAAC | p.Gly111_Val112insPheTerIleCysTyrValValThr | p.G111_V112insF*ICYVVT | Q96CB8 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
INTS12 | insertion | Frame_Shift_Ins | novel | c.191_192insA | p.Asn64LysfsTer5 | p.N64Kfs*5 | Q96CB8 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
INTS12 | SNV | Missense_Mutation | c.804N>T | p.Lys268Asn | p.K268N | Q96CB8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
INTS12 | SNV | Missense_Mutation | novel | c.1000N>G | p.Thr334Ala | p.T334A | Q96CB8 | protein_coding | deleterious_low_confidence(0.04) | benign(0.058) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INTS12 | SNV | Missense_Mutation | novel | c.1123C>T | p.Arg375Cys | p.R375C | Q96CB8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.513) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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