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Gene: IDO1 |
Gene summary for IDO1 |
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Gene information | Species | Human | Gene symbol | IDO1 | Gene ID | 3620 |
Gene name | indoleamine 2,3-dioxygenase 1 | |
Gene Alias | IDO | |
Cytomap | 8p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P14902 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3620 | IDO1 | C30 | Human | Oral cavity | OSCC | 2.17e-16 | 1.11e+00 | 0.3055 |
3620 | IDO1 | C38 | Human | Oral cavity | OSCC | 3.61e-03 | 2.67e-01 | 0.172 |
3620 | IDO1 | C43 | Human | Oral cavity | OSCC | 1.36e-07 | 5.81e-01 | 0.1704 |
3620 | IDO1 | C46 | Human | Oral cavity | OSCC | 7.26e-11 | 4.82e-01 | 0.1673 |
3620 | IDO1 | C57 | Human | Oral cavity | OSCC | 6.97e-19 | 9.69e-01 | 0.1679 |
3620 | IDO1 | LN22 | Human | Oral cavity | OSCC | 5.72e-05 | 1.37e+00 | 0.1733 |
3620 | IDO1 | LN46 | Human | Oral cavity | OSCC | 9.20e-04 | 4.76e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00229009 | Cervix | CC | electron transport chain | 53/2311 | 175/18723 | 2.23e-10 | 3.43e-08 | 53 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00075654 | Cervix | CC | female pregnancy | 43/2311 | 193/18723 | 7.62e-05 | 1.04e-03 | 43 |
GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
GO:00447064 | Cervix | CC | multi-multicellular organism process | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00442709 | Cervix | CC | cellular nitrogen compound catabolic process | 79/2311 | 451/18723 | 7.80e-04 | 6.91e-03 | 79 |
GO:00194398 | Cervix | CC | aromatic compound catabolic process | 79/2311 | 467/18723 | 2.14e-03 | 1.54e-02 | 79 |
GO:19013618 | Cervix | CC | organic cyclic compound catabolic process | 80/2311 | 495/18723 | 6.77e-03 | 3.72e-02 | 80 |
GO:000911710 | Cervix | CC | nucleotide metabolic process | 79/2311 | 489/18723 | 7.16e-03 | 3.85e-02 | 79 |
GO:000756512 | Cervix | HSIL_HPV | female pregnancy | 26/737 | 193/18723 | 4.32e-08 | 3.41e-06 | 26 |
GO:004470611 | Cervix | HSIL_HPV | multi-multicellular organism process | 27/737 | 220/18723 | 1.69e-07 | 1.03e-05 | 27 |
GO:002290014 | Cervix | HSIL_HPV | electron transport chain | 18/737 | 175/18723 | 1.93e-04 | 3.56e-03 | 18 |
GO:000609114 | Cervix | HSIL_HPV | generation of precursor metabolites and energy | 32/737 | 490/18723 | 3.69e-03 | 3.27e-02 | 32 |
GO:000609110 | Endometrium | AEH | generation of precursor metabolites and energy | 121/2100 | 490/18723 | 1.65e-17 | 8.23e-15 | 121 |
GO:002290010 | Endometrium | AEH | electron transport chain | 60/2100 | 175/18723 | 4.37e-16 | 1.75e-13 | 60 |
GO:00075655 | Endometrium | AEH | female pregnancy | 43/2100 | 193/18723 | 7.52e-06 | 1.80e-04 | 43 |
GO:004427010 | Endometrium | AEH | cellular nitrogen compound catabolic process | 80/2100 | 451/18723 | 2.09e-05 | 4.13e-04 | 80 |
GO:00467009 | Endometrium | AEH | heterocycle catabolic process | 79/2100 | 445/18723 | 2.27e-05 | 4.35e-04 | 79 |
GO:00447065 | Endometrium | AEH | multi-multicellular organism process | 45/2100 | 220/18723 | 4.55e-05 | 7.61e-04 | 45 |
GO:00194399 | Endometrium | AEH | aromatic compound catabolic process | 80/2100 | 467/18723 | 7.21e-05 | 1.10e-03 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IDO1 | SNV | Missense_Mutation | rs761098064 | c.950N>A | p.Arg317His | p.R317H | P14902 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1ES-06 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
IDO1 | SNV | Missense_Mutation | rs756117395 | c.986G>A | p.Arg329Gln | p.R329Q | P14902 | protein_coding | tolerated(0.69) | benign(0) | TCGA-S3-A6ZH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
IDO1 | SNV | Missense_Mutation | rs370075063 | c.463N>T | p.Arg155Cys | p.R155C | P14902 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IDO1 | SNV | Missense_Mutation | rs774225205 | c.691N>T | p.Arg231Cys | p.R231C | P14902 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IDO1 | SNV | Missense_Mutation | c.1107A>C | p.Glu369Asp | p.E369D | P14902 | protein_coding | tolerated(0.36) | benign(0.423) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
IDO1 | SNV | Missense_Mutation | c.820G>A | p.Asp274Asn | p.D274N | P14902 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
IDO1 | SNV | Missense_Mutation | c.87N>T | p.Gln29His | p.Q29H | P14902 | protein_coding | deleterious(0) | benign(0.269) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IDO1 | SNV | Missense_Mutation | c.998A>G | p.Asp333Gly | p.D333G | P14902 | protein_coding | deleterious(0) | possibly_damaging(0.637) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
IDO1 | SNV | Missense_Mutation | rs12545878 | c.348N>T | p.Lys116Asn | p.K116N | P14902 | protein_coding | deleterious(0.02) | benign(0.387) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IDO1 | SNV | Missense_Mutation | rs370075063 | c.463C>T | p.Arg155Cys | p.R155C | P14902 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | Benzimidazole and imadazopyridine carboximidamide compound 1 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | Cyclic hydroxamate derivative 1 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | PHENYLHYDRAZINE | PHENYLHYDRAZINE | 24262887 | |
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | 363894234 | ||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | Biphenyl derivative 2 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | PMID29473428-Compound-14 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | 2,3-diamino-benzo[b]thiophene derivative 8 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | NLG8189 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | PMID29473428-Compound-53 | |||
3620 | IDO1 | ENZYME, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | 249565907 |
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